- CHMP2B mutants linked to frontotemporal dementia impair maturation of dendritic spines
[作者:Belly, A; Bodon, G; Blot, B; Bouron, A; Sadoul, R; Goldberg, Y,期刊:Journal of cell science, 页码:2943-2954 , 文章类型: Article,,卷期:2010年123-17]
- The highly conserved ESCRT-III complex is responsible for deformation and cleavage of membranes during endosomal trafficking and other cellular activities. In humans, dominant mutations in the ESCRT-III subunit CHMP2B ca...
- Cytoskeletal dysfunction dominates in DAP12-deficient osteoclasts
[作者:Zou, W; Zhu, TT; Craft, CS; Broekelmann, TJ; Mecham, RP; Teitelbaum, SL,期刊:Journal of cell science, 页码:2955-2963 , 文章类型: Article,,卷期:2010年123-17]
- Despite evidence that DAP12 regulates osteoclasts, mice lacking the ITAM-bearing protein exhibit only mild osteopetrosis. Alternatively, Dap12(-/-) mice, also lacking FcR gamma, are severely osteopetrotic, suggesting tha...
- Protein mobilities and P-selectin storage in Weibel-Palade bodies
[作者:Kiskin, NI; Hellen, N; Babich, V; Hewlett, L; Knipe, L; Hannah, MJ; Carter, T,期刊:Journal of cell science, 页码:2964-2975 , 文章类型: Article,,卷期:2010年123-17]
- Using fluorescence recovery after photobleaching (FRAP) we measured the mobilities of EGFP-tagged soluble secretory proteins in the endoplasmic reticulum (ER) and in individual Weibel-Palade bodies (WPBs) at early (immat...
- Casein kinase 1 regulates human hypoxia-inducible factor HIF-1
[作者:Kalousi, A; Mylonis, I; Politou, AS; Chachami, G; Paraskeva, E; Simos, G,期刊:Journal of cell science, 页码:2976-2986 , 文章类型: Article,,卷期:2010年123-17]
- Hypoxia-inducible factor 1 (HIF-1), a transcriptional activator that mediates cellular response to hypoxia and a promising target of anticancer therapy, is essential for adaptation to low oxygen conditions, embryogenesis...
- Lumican is required for neutrophil extravasation following corneal injury and wound healing
[作者:Hayashi, Y; Call, MK; Chikama, TI; Liu, HS; Carlson, EC; Sun, Y; Pearlman, E; Funderburgh, JL; Babcock, G; Liu, CY; Ohashi, Y; Kao, WWY,期刊:Journal of cell science, 页码:2987-2995 , 文章类型: Article,,卷期:2010年123-17]
- An important aspect of wound healing is the recruitment of neutrophils to the site of infection or tissue injury. Lumican, an extracellular matrix component belonging to the small leucine rich proteoglycan (SLRP) family,...
- Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF beta
[作者:Massam-Wu, T; Chiu, MB; Choudhury, R; Chaudhry, SS; Baldwin, AK; McGovern, A; Baldock, C; Shuttleworth, CA; Kielty, CM,期刊:Journal of cell science, 页码:3006-3018 , 文章类型: Article,,卷期:2010年123-17]
- Control of the bioavailability of the growth factor TGF beta is essential for tissue formation and homeostasis, yet precisely how latent TGF beta is incorporated into the extracellular matrix is unknown. Here, we show th...
- Decoupling diffusional from dimensional control of signaling in 3D culture reveals a role for myosin in tubulogenesis
[作者:Raghavan, S; Shen, CJ; Desai, RA; Sniadecki, NJ; Nelson, CM; Chen, CS,期刊:Journal of cell science, 页码:2877-2883 , 文章类型: Article,,卷期:2010年123-17]
- We present a novel microfabricated platform to culture cells within arrays of micrometer-scale three-dimensional (3D) extracellular matrix scaffolds (microgels). These microscale cultures eliminate diffusion barriers tha...
- Basal body movements orchestrate membrane organelle division and cell morphogenesis in Trypanosoma brucei
[作者:Lacomble, S; Vaughan, S; Gadelha, C; Morphew, MK; Shaw, MK; McIntosh, JR; Gull, K,期刊:Journal of cell science, 页码:2884-2891 , 文章类型: Article,,卷期:2010年123-17]
- The defined shape and single-copy organelles of Trypanosoma brucei mean that it provides an excellent model in which to study how duplication and segregation of organelles is interfaced with morphogenesis of overall cell...
- Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response
[作者:Malzer, E; Daly, ML; Moloney, A; Sendall, TJ; Thomas, SE; Ryder, E; Ryoo, HD; Crowther, DC; Lomas, DA; Marciniak, SJ,期刊:Journal of cell science, 页码:2892-2900 , 文章类型: Article,,卷期:2010年123-17]
- The integrated stress response (ISR) protects cells from numerous forms of stress and is involved in the growth of solid tumours; however, it is unclear how the ISR acts on cellular proliferation. We have developed a mod...
- Elevated expression of protein kinase C delta induces cell scattering upon serum deprivation
[作者:Chen, CL; Chan, PC; Wang, SH; Pan, YR; Chen, HC,期刊:Journal of cell science, 页码:2901-2913 , 文章类型: Article,,卷期:2010年123-17]
- Tumor metastasis might be evoked in response to microenvironmental stress, such as a shortage of oxygen. Although the cellular response to hypoxia has been well established, we know little about how tumors adapt themselv...
- TIMP3: a physiological regulator of adult myogenesis
[作者:Liu, HJ; Chen, SE; Jin, BW; Carson, JA; Niu, AR; Durham, W; Lai, JY; Li, YP,期刊:Journal of cell science, 页码:2914-2921 , 文章类型: Article,,卷期:2010年123-17]
- Myogenic differentiation in adult muscle is normally suppressed and can be activated by myogenic cues in a subset of activated satellite cells. The switch mechanism that turns myogenesis on and off is not defined. In the...
- Control of Notch-ligand endocytosis by ligand-receptor interaction
[作者:Hansson, EM; Lanner, F; Das, D; Mutvei, A; Marklund, U; Ericson, J; Farnebo, F; Stumm, G; Stenmark, H; Andersson, ER; Lendahl, U,期刊:Journal of cell science, 页码:2931-2942 , 文章类型: Article,,卷期:2010年123-17]
- In Notch signaling, cell-bound ligands activate Notch receptors on juxtaposed cells, but the relationship between ligand endocytosis, ubiquitylation and ligand-receptor interaction remains poorly understood. To study the...
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