- N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms
[作者:Di Benedetto, A; Watkins, M; Grimston, S; Salazar, V; Donsante, C; Mbalaviele, G; Radice, GL; Civitelli, R,期刊:Journal of cell science, 页码:2640-2648 , 文章类型: Article,,卷期:2010年123-15]
- We have previously shown that targeted expression of a dominant-negative truncated form of N-cadherin (Cdh2) delays acquisition of peak bone mass in mice and retards osteoblast differentiation; whereas deletion of cadher...
- The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association
[作者:Obata, Y; Fukumoto, Y; Nakayama, Y; Kuga, T; Dohmae, N; Yamaguchi, N,期刊:Journal of cell science, 页码:2649-2662 , 文章类型: Article,,卷期:2010年123-15]
- The Src-family tyrosine kinase Lyn has a role in signal transduction at the cytoplasmic face of the plasma membrane upon extracellular ligand stimulation. After synthesis in the cytoplasm, Lyn accumulates on the Golgi an...
- Chromatin interaction of TATA-binding protein is dynamically regulated in human cells
[作者:de Graaf, P; Mousson, F; Geverts, B; Scheer, E; Tora, L; Houtsmuller, AB; Timmers, HTM,期刊:Journal of cell science, 页码:2663-2671 , 文章类型: Article,,卷期:2010年123-15]
- Gene transcription in mammalian cells is a dynamic process involving regulated assembly of transcription complexes on chromatin in which the TATA-binding protein (TBP) plays a central role. Here, we investigate the dynam...
- Attenuation of microRNA-1 derepresses the cytoskeleton regulatory protein twinfilin-1 to provoke cardiac hypertrophy (vol 123, pg 2444, 2010)
[作者:Li, Q; Song, XW; Zou, J; Wang, GK; Kremneva, E; Li, XQ; Zhu, N; Lappalainen, P; Yuan, WJ; Qin, YW; Jing, Q,期刊:Journal of cell science, 页码:2680-2680 , 文章类型: Correction,,卷期:2010年123-15]
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- New insights into the role of mitochondria in aging: mitochondrial dynamics and more
[作者:Seo, AY; Joseph, AM; Dutta, D; Hwang, JCY; Aris, JP; Leeuwenburgh, C,期刊:Journal of cell science, 页码:2533-2542 , 文章类型: Editorial Material,,卷期:2010年123-15]
- A decline in mitochondrial function plays a key role in the aging process and increases the incidence of age-related disorders. A deeper understanding of the intricate nature of mitochondrial dynamics, which is described...
- Syncoilin modulates peripherin filament networks and is necessary for large-calibre motor neurons
[作者:Clarke, WT; Edwards, B; McCullagh, KJA; Kemp, MW; Moorwood, C; Sherman, DL; Burgess, M; Davies, KE,期刊:Journal of cell science, 页码:2543-2552 , 文章类型: Article,,卷期:2010年123-15]
- Syncoilin is an atypical type III intermediate filament (IF) protein, which is expressed in muscle and is associated with the dystrophin-associated protein complex. Here, we show that syncoilin is expressed in both the c...
- Mitochondrial Ca2+ uptake and not mitochondrial motility is required for STIM1-Orai1-dependent store-operated Ca2+ entry
[作者:Naghdi, S; Waideck-Weiermair, M; Fertschai, I; Poteser, M; Graier, WF; Malli, R,期刊:Journal of cell science, 页码:2553-2564 , 文章类型: Article,,卷期:2010年123-15]
- Store-operated Ca2+ entry (SOCE) is established by formation of subplasmalemmal clusters of the endoplasmic reticulum (ER) protein, stromal interacting molecule 1 (STIM1) upon ER Ca2+ depletion. Thereby, STIM1 couples to...
- Btk-dependent Rac activation and actin rearrangement following Fc epsilon RI aggregation promotes enhanced chemotactic responses of mast cells
[作者:Kuehn, HS; Radinger, M; Brown, JM; Ali, K; Vanhaesebroeck, B; Beaven, MA; Metcalfe, DD; Gilfillan, AM,期刊:Journal of cell science, 页码:2576-2585 , 文章类型: Article,,卷期:2010年123-15]
- Mast cells infiltrate the sites of inflammation associated with chronic atopic disease and during helminth and bacterial infection. This process requires receptor-mediated cell chemotaxis across a concentration gradient ...
- RINGO C is required to sustain the spindle-assembly checkpoint
[作者:Mouron, S; de Carcer, G; Seco, E; Fernandez-Miranda, G; Malumbres, M; Nebreda, AR,期刊:Journal of cell science, 页码:2586-2595 , 文章类型: Article,,卷期:2010年123-15]
- RINGO/Speedy proteins are direct activators of Cdk1 and Cdk2 that have no sequence homology to cyclins. We have characterized the role in cell-cycle progression of a new human member of this protein family referred to as...
- p38 gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock
[作者:Sabio, G; Cerezo-Guisado, MI; del Reino, P; Inesta-Vaquera, FA; Rousseau, S; Arthur, JSC; Campbell, DG; Centeno, F; Cuenda, A,期刊:Journal of cell science, 页码:2596-2604 , 文章类型: Article,,卷期:2010年123-15]
- Activation of p38 gamma modulates the integrity of the complex formed by the human discs large protein (hDlg) with cytoskeletal proteins, which is important for cell adaptation to changes in environmental osmolarity. Her...
- JunB-CBF beta signaling is essential to maintain sarcomeric Z-disc structure and when defective leads to heart failure
[作者:Meder, B; Just, S; Vogel, B; Rudloff, J; Gartner, L; Dahme, T; Huttner, I; Zankl, A; Katus, HA; Rottbauer, W,期刊:Journal of cell science, 页码:2613-2620 , 文章类型: Article,,卷期:2010年123-15]
- In muscle cells, a complex network of Z-disc proteins allows proper reception, transduction and transmission of mechanical and biochemical signals. Mutations in genes encoding different Z-disc proteins such as integrin-l...
- A p120-catenin-CK1 epsilon complex regulates Wnt signaling
[作者:Casagolda, D; del Valle-Perez, B; Valls, G; Lugilde, E; Vinyoles, M; Casado-Vela, J; Solanas, G; Batlle, E; Reynolds, AB; Casal, JI; de Herreros, AG; Dunach, M,期刊:Journal of cell science, 页码:2621-2631 , 文章类型: Article,,卷期:2010年123-15]
- p120-catenin is an E-cadherin-associated protein that modulates E-cadherin function and stability. We describe here that p120-catenin is required for Wnt pathway signaling. p120-catenin binds and is phosphorylated by CK1...
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