- The nuclear protein Waharan is required for endosomal-lysosomal trafficking in Drosophila
[作者:Lone, M; Kungl, T; Koper, A; Bottenberg, W; Kammerer, R; Klein, M; Sweeney, ST; Auburn, RP; O'Kane, CJ; Prokop, A,期刊:Journal of cell science, 页码:2369-2374 , 文章类型: Article,,卷期:2010年123-14]
- Here we report Drosophila Waharan (Wah), a 170-kD predominantly nuclear protein with two potential human homologues, as a newly identified regulator of endosomal trafficking. Wah is required for neuromuscular-junction de...
- Interplay between BCL10, MALT1 and I kappa B alpha during T-cell-receptor-mediated NF kappa B activation
[作者:Carvalho, G; Le Guelte, A; Demian, C; Vazquez, A; Gavard, J; Bidere, N,期刊:Journal of cell science, 页码:2375-2380 , 文章类型: Article,,卷期:2010年123-14]
- T-cell-receptor (TCR) signalling to NF kappa B requires the assembly of a large multiprotein complex containing the serine/threonine kinase CK1 alpha, the scaffold protein CARMA1, the heterodimer BCL10-MALT1 (the CBM com...
- AGAP2 regulates retrograde transport between early endosomes and the TGN
[作者:Shiba, Y; Romer, W; Mardones, GA; Burgos, PV; Lamaze, C; Johannes, L,期刊:Journal of cell science, 页码:2381-2390 , 文章类型: Article,,卷期:2010年123-14]
- The retrograde transport route links early endosomes and the TGN. Several endogenous and exogenous cargo proteins use this pathway, one of which is the well-explored bacterial Shiga toxin. ADP-ribosylation factors (Arfs)...
- Control of ciliogenesis by FOR20, a novel centrosome and pericentriolar satellite protein
[作者:Sedjai, F; Acquaviva, C; Chevrier, V; Chauvin, JP; Coppin, E; Aouane, A; Coulier, F; Tolun, A; Pierres, M; Birnbaum, D; Rosnet, O,期刊:Journal of cell science, 页码:2391-2401 , 文章类型: Article,,卷期:2010年123-14]
- Cilia and flagella are evolutionary conserved organelles that generate fluid movement and locomotion, and play roles in chemosensation, mechanosensation and intracellular signalling. In complex organisms, cilia are highl...
- Hepatocytes lacking thioredoxin reductase 1 have normal replicative potential during development and regeneration
[作者:Rollins, MF; van der Heide, DM; Weisend, CM; Kundert, JA; Comstock, KM; Suvorova, ES; Capecchi, MR; Merrill, GF; Schmidt, EE,期刊:Journal of cell science, 页码:2402-2412 , 文章类型: Article,,卷期:2010年123-14]
- Cells require ribonucleotide reductase (RNR) activity for DNA replication. In bacteria, electrons can flow from NADPH to RNR by either a thioredoxin-reductase- or a glutathione-reductase-dependent route. Yeast and plants...
- Myoferlin regulation by NFAT in muscle injury, regeneration and repair
[作者:Demonbreun, AR; Lapidos, KA; Heretis, K; Levin, S; Dale, R; Pytel, P; Svensson, EC; McNally, EM,期刊:Journal of cell science, 页码:2413-2422 , 文章类型: Article,,卷期:2010年123-14]
- Ferlin proteins mediate membrane-fusion events in response to Ca2+. Myoferlin, a member of the ferlin family, is required for normal muscle development, during which it mediates myoblast fusion. We isolated both damaged ...
- MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation
[作者:Galli, F; Rossi, M; D'Alessandra, Y; De Simone, M; Lopardo, T; Haupt, Y; Alsheich-Bartok, O; Anzi, S; Shaulian, E; Calabro, V; La Mantia, G; Guerrini, L,期刊:Journal of cell science, 页码:2423-2433 , 文章类型: Article,,卷期:2010年123-14]
- Tight control of p63 protein levels must be achieved under differentiation or apoptotic conditions. Here, we describe a new regulatory pathway for the Delta Np63 alpha protein. We found that MDM2 binds Delta Np63 alpha i...
- NHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acid
[作者:Cha, BY; Zhu, XJC; Chen, WP; Jones, M; Ryoo, S; Zachos, NC; Chen, TE; Lin, R; Sarker, R; Kenworthy, AK; Tse, M; Kovbasnjuk, O; Donowitz, M,期刊:Journal of cell science, 页码:2434-2443 , 文章类型: Article,,卷期:2010年123-14]
- The epithelial brush border (BB) Na+/H+ exchanger NHE3 is associated with the actin cytoskeleton by binding both directly and indirectly to ezrin; indirect binding is via attachment to NHERF family proteins. NHE3 mobilit...
- Attenuation of microRNA-1 derepresses the cytoskeleton regulatory protein twinfilin-1 to provoke cardiac hypertrophy
[作者:Li, Q; Song, XW; Zou, J; Wang, GK; Kremneva, E; Li, XQ; Zhu, N; Sun, T; Lappalainen, P; Yuan, WJ; Qin, YW; Jing, Q,期刊:Journal of cell science, 页码:2444-2452 , 文章类型: Article,,卷期:2010年123-14]
- MicroRNAs are involved in several aspects of cardiac hypertrophy, including cardiac growth, conduction, and fibrosis. However, their effects on the regulation of the cardiomyocyte cytoskeleton in this pathological proces...
- Temporal regulation of the muscle gene cascade by Macho1 and Tbx6 transcription factors in Ciona intestinalis
[作者:Kugler, JE; Gazdoiu, S; Oda-Ishii, I; Passamaneck, YJ; Erives, AJ; Di Gregorio, A,期刊:Journal of cell science, 页码:2453-2463 , 文章类型: Article,,卷期:2010年123-14]
- For over a century, muscle formation in the ascidian embryo has been representative of 'mosaic' development. The molecular basis of muscle-fate predetermination has been partly elucidated with the discovery of Macho1, a ...
- Telomerase trafficking and assembly in Xenopus oocytes
[作者:Li, ZH; Tomlinson, RL; Terns, RM; Terns, MP,期刊:Journal of cell science, 页码:2464-2472 , 文章类型: Article,,卷期:2010年123-14]
- The core components of telomerase are telomerase RNA (TR) and telomerase reverse transcriptase (TERT). In vertebrate cells, TR and TERT have been reported to associate with intranuclear structures, including Cajal bodies...
- Transmembrane-domain determinants for SNARE-mediated membrane fusion
[作者:Fdez, E; Martinez-Salvador, M; Beard, M; Woodman, P; Hilfiker, S,期刊:Journal of cell science, 页码:2473-2480 , 文章类型: Article,,卷期:2010年123-14]
- Neurosecretion involves fusion of vesicles with the plasma membrane. Such membrane fusion is mediated by the SNARE complex, which is composed of the vesicle-associated protein synaptobrevin (VAMP2), and the plasma membra...
- alpha 2 beta 1 integrin controls association of Rac with the membrane and triggers quiescence of endothelial cells
[作者:Cailleteau, L; Estrach, S; Thyss, R; Boyer, L; Doye, A; Domange, B; Johnsson, N; Rubinstein, E; Boucheix, C; Ebrahimian, T; Silvestre, JS; Lemichez, E; Meneguzzi, G; Mettouchi, A,期刊:Journal of cell science, 页码:2491-2501 , 文章类型: Article,,卷期:2010年123-14]
- Integrin receptors and their extracellular matrix ligands provide cues to cell proliferation, survival, differentiation and migration. Here, we show that alpha 2 beta 1 integrin, when ligated to the basement membrane com...
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