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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共13条记录   P2X7 receptor antagonism in the treatment of cancers [作者：Roger, S; Pelegrin, P,期刊：Expert opinion on investigational drugs, 页码：875-880 , 文章类型： Editorial Material，,卷期：2011年20-7] ATP-gated P2X7 receptors (P2X7) make a unique family of extracellular ATP-activated plasma membrane ion channels expressed in haematopoietic and epithelial cells. They have been extensively studied in immune cells where ... Combining temozolomide with other antitumor drugs and target-based agents in the treatment of brain metastases: an unending quest or chasing a chimera? [作者：Addeo, R; Caraglia, M,期刊：Expert opinion on investigational drugs, 页码：881-895 , 文章类型： Review，,卷期：2011年20-7] Areas covered: This review summarizes TMZ--WBRT combination trials highlighting the confounding factors that limit the interpretation of the achieved results and describes the main clinical trials using TMZ in combinatio... A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases [作者：Arulkumaran, N; Unwin, RJ; Tam, FWK,期刊：Expert opinion on investigational drugs, 页码：897-915 , 文章类型： Review，,卷期：2011年20-7] Areas covered: We have reviewed the current literature on the role of the P2X7R in inflammatory diseases, focusing on potential therapeutic applications of selective P2X7R antagonists as anti-inflammatory agents. Particu... Are aromatase inhibitors effective in endometriosis treatment? [作者：Colette, S; Donnez, J,期刊：Expert opinion on investigational drugs, 页码：917-931 , 文章类型： Review，,卷期：2011年20-7] Areas covered: In endometriosis, aromatase was long thought to be involved in the in situ formation of estrogens, leading to a positive feedback loop favoring estrogens, themselves inducing prostaglandin production and i... New targeted therapies for renal cell carcinoma [作者：Fisher, R; Pickering, L; Larkin, J,期刊：Expert opinion on investigational drugs, 页码：933-945 , 文章类型： Review，,卷期：2011年20-7] Areas covered: This review discusses the molecular targets in renal cell carcinoma relevant to the development of new treatments and describes the progress of novel therapies. The evidence is compiled from the PubMed dat... Medical treatment of glaucoma: present and future [作者：Fogagnolo, P; Rossetti, L,期刊：Expert opinion on investigational drugs, 页码：947-959 , 文章类型： Review，,卷期：2011年20-7] Areas covered: This review covers the strategies currently used to achieve effective medical reduction of intraocular pressure in clinical practice; treatments that are currently been experimented in humans and that may ... New JAK2 inhibitors for myeloproliferative neoplasms [作者：Quintas-Cardama, A; Verstovsek, S,期刊：Expert opinion on investigational drugs, 页码：961-972 , 文章类型： Review，,卷期：2011年20-7] Areas covered: Several JAK2 kinase inhibitors are being tested in clinical trials for patients with MPNs. In PMF trials, JAK2 inhibitors have been shown to produce rapid reductions in spleen size and marked improvements ... Targeted therapies in bone sarcomas: current approach and future directions [作者：Yarber, JL; Agulnik, M,期刊：Expert opinion on investigational drugs, 页码：973-979 , 文章类型： Review，,卷期：2011年20-7] Areas covered: Specific molecular targets of bone sarcomas are reviewed along with the various targeted therapies that have potential to change the outcome of these chemotherapy resistant diseases.Expert opinion: There a... VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis [作者：Horak, F,期刊：Expert opinion on investigational drugs, 页码：981-986 , 文章类型： Editorial Material，,卷期：2011年20-7] Areas covered: The rationale for TLR8 as a therapeutic target in allergic disease is summarized. The potency of VTX-1463 for TLR8 is outlined, and preclinical efficacy data from a ragweed-sensitized beagle dog model of a... Tasimelteon for insomnia [作者：Lankford, DA,期刊：Expert opinion on investigational drugs, 页码：987-993 , 文章类型： Editorial Material，,卷期：2011年20-7] Areas covered: The nature and prevalence of insomnia are described in this review, along with the current pharmacological treatments for the disorder. Summaries of the available pharmacological and clinical data for tasi... Amonafide: a potential role in treating acute myeloid leukemia [作者：Allen, SL; Lundberg, AS,期刊：Expert opinion on investigational drugs, 页码：995-1003 , 文章类型： Editorial Material，,卷期：2011年20-7] Areas covered: In vitro, Pgp-mediated transport (efflux) of amonafide from myeloblasts obtained from patients with secondary acute myeloid leukemia (sAML) was significantly less than efflux of daunorubicin. Amonafide has... Clofarabine for myelodysplastic syndromes [作者：Tiu, RV; Traina, F; Sekeres, MA,期刊：Expert opinion on investigational drugs, 页码：1005-1014 , 文章类型： Editorial Material，,卷期：2011年20-7] Areas covered: A PubMed search for articles pertaining to clofarabine was conducted and streamlined to only include data on MDS or AML that evolved from MDS. Also included were clofarabine-related response and safety dat... From cell biology to therapy: ENMD-2076 in the treatment of multiple myeloma [作者：Zhang, SH; Farag, SS,期刊：Expert opinion on investigational drugs, 页码：1015-1028 , 文章类型： Editorial Material，,卷期：2011年20-7] Areas covered: In this review, the authors summarize the preclinical in vitro and in vivo data that have formed the rationale for clinical investigation of ENMD-2076 in MM. In addition, the authors review the early clini...