- E6AP is required for replicative and oncogene-induced senescence in mouse embryo fibroblasts
[作者:Levav-Cohen, Y; Wolyniec, K; Alsheich-Bartok, O; Chan, AL; Woods, SJ; Jiang, YH; Haupt, S; Haupt, Y,期刊:Oncogene, 页码:2199-2209 , 文章类型: Article,,卷期:2012年31-17]
- Cellular senescence is important for the maintenance of tissue homeostasis, and has recently been shown to pose a natural barrier to tumorigenesis. The E3 ubiquitin ligase, E6AP, has been linked to a number of protein re...
- Key role of ATF3 in p53-dependent DR5 induction upon DNA damage of human colon cancer cells
[作者:Taketani, K; Kawauchi, J; Tanaka-Okamoto, M; Ishizaki, H; Tanaka, Y; Sakai, T; Miyoshi, J; Maehara, Y; Kitajima, S,期刊:Oncogene, 页码:2210-2221 , 文章类型: Article,,卷期:2012年31-17]
- Stress response gene ATF3 is one of the p53 target genes and has a tumor suppressor role in cancer. However, the biological role of p53-ATF3 pathway is not well understood. Death receptor 5 (DR5) is a death domain-contai...
- G1P3, an interferon- and estrogen-induced survival protein contributes to hyperplasia, tamoxifen resistance and poor outcomes in breast cancer
[作者:Cheriyath, V; Kuhns, MA; Jacobs, BS; Evangelista, P; Elson, P; Downs-Kelly, E; Tubbs, R; Borden, EC,期刊:Oncogene, 页码:2222-2236 , 文章类型: Article,,卷期:2012年31-17]
- Hormonally regulated survival factors can have an important role in breast cancer. Here we elucidate G1P3, a survival protein induced by interferons (IFNs), as a target of estrogen signaling and a contributor to poor out...
- Loss of breast epithelial marker hCLCA2 promotes epithelial-to-mesenchymal transition and indicates higher risk of metastasis
[作者:Walia, V; Yu, Y; Cao, D; Sun, M; McLean, JR; Hollier, BG; Cheng, J; Mani, SA; Rao, K; Premkumar, L; Elble, RC,期刊:Oncogene, 页码:2237-2246 , 文章类型: Article,,卷期:2012年31-17]
- Transition between epithelial and mesenchymal states is a feature of both normal development and tumor progression. We report that expression of chloride channel accessory protein hCLCA2 is a characteristic of epithelial...
- Breast cancer genome-wide association studies: there is strength in numbers
[作者:Fanale, D; Amodeo, V; Corsini, LR; Rizzo, S; Bazan, V; Russo, A,期刊:Oncogene, 页码:2121-2128 , 文章类型: Review,,卷期:2012年31-17]
- Breast cancer (BC) is a heterogeneous disease that exhibits familial aggregation. Family linkage studies have identified high-penetrance genes, BRCA1, BRCA2, PTEN and TP53, that are responsible for inherited BC syndromes...
- Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Pol gamma against UV-induced inactivation
[作者:Bakthavatchalu, V; Dey, S; Xu, Y; Noel, T; Jungsuwadee, P; Holley, AK; Dhar, SK; Batinic-Haberle, I; St Clair, DK,期刊:Oncogene, 页码:2129-2139 , 文章类型: Article,,卷期:2012年31-17]
- Manganese superoxide dismutase is a nuclear encoded primary antioxidant enzyme localized exclusively in the mitochondrial matrix. Genotoxic agents, such as ultraviolet (UV) radiation, generates oxidative stress and cause...
- Development of a Listeria monocytogenes-based vaccine against hepatocellular carcinoma
[作者:Chen, Y; Yang, D; Li, S; Gao, Y; Jiang, R; Deng, L; Frankel, FR; Sun, B,期刊:Oncogene, 页码:2140-2152 , 文章类型: Article,,卷期:2012年31-17]
- Live attenuated Listeria monocytogenes (LM) is a promising bacterial vector able to induce a T-cell response to tumor-associated antigens and demonstrates great potential for use in vaccine development. A novel recombina...
- Overexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer
[作者:Urbanucci, A; Sahu, B; Seppala, J; Larjo, A; Latonen, LM; Waltering, KK; Tammela, TLJ; Vessella, RL; Lahdesmaki, H; Janne, OA; Visakorpi, T,期刊:Oncogene, 页码:2153-2163 , 文章类型: Article,,卷期:2012年31-17]
- Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin binding of the receptor and to identify AR ...
- The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation
[作者:Buijs, JT; van der Horst, G; van den Hoogen, C; Cheung, H; de Rooij, B; Kroon, J; Petersen, M; van Overveld, PGM; Pelger, RCM; van der Pluijm, G,期刊:Oncogene, 页码:2164-2174 , 文章类型: Article,,卷期:2012年31-17]
- Accumulating evidence suggests that a subpopulation of breast cancer cells, referred to as cancer stem cells (CSCs), have the ability to propagate a tumor and potentially seed new metastases. Furthermore, stimulation of ...
- Mucin 1 enhances the tumor angiogenic response by activation of the AKT signaling pathway
[作者:Woo, JK; Choi, Y; Oh, SH; Jeong, JH; Choi, DH; Seo, HS; Kim, CW,期刊:Oncogene, 页码:2187-2198 , 文章类型: Article,,卷期:2012年31-17]
- Although the hyper-glycosylated transmembrane protein Mucin 1 (MUC1) is aberrantly overexpressed in human breast carcinoma, the biological significance of MUC1 overexpression is unclear. This study showed that MUC1 expre...
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