- Distinct Roles of Secreted HtrA Proteases from Gram-negative Pathogens in Cleaving the Junctional Protein and Tumor Suppressor E-cadherin
[作者：Hoy, B; Geppert, T; Boehm, M; Reisen, F; Plattner, P; Gadermaier, G; Sewald, N; Ferreira, F; Briza, P; Schneider, G; Backert, S; Wessler, S,期刊：Journal of Biological Chemistry, 页码：10115-10120 , 文章类型： Article，,卷期：2012年287-13]
- The periplasmic chaperone and serine protease HtrA is important for bacterial stress responses and protein quality control. Recently, we discovered that HtrA from Helicobacter pylori is secreted and cleaves E-cadherin to...
- SEC23-SEC31 the Interface Plays Critical Role for Export of Procollagen from the Endoplasmic Reticulum
[作者：Kim, SD; Pahuja, KB; Ravazzola, M; Yoon, J; Boyadjiev, SA; Hammamoto, S; Schekman, R; Orci, L; Kim, J,期刊：Journal of Biological Chemistry, 页码：10134-10144 , 文章类型： Article，,卷期：2012年287-13]
- COPII proteins are essential for exporting most cargo molecules from the endoplasmic reticulum. The membrane-facing surface of the COPII proteins (especially SEC23-SEC24) interacts directly or indirectly with the cargo m...
- Protein Phosphatase 1 alpha Mediates Ceramide-induced ERM Protein Dephosphorylation A NOVEL MECHANISM INDEPENDENT OF PHOSPHATIDYLINOSITOL 4, 5-BIPHOSPHATE (PIP2) AND MYOSIN/ERM PHOSPHATASE
[作者：Canals, D; Roddy, P; Hannun, YA,期刊：Journal of Biological Chemistry, 页码：10145-10155 , 文章类型： Article，,卷期：2012年287-13]
- ERM (ezrin, radixin, and moesin) proteins are cytoskeletal interacting proteins that bind cortical actin, the plasma membrane, and membrane proteins, which are found in specialized plasma membrane structures such as micr...
- Follicle-stimulating Hormone Regulates Pro-apoptotic Protein Bcl-2-interacting Mediator of Cell Death-Extra Long (Bim(EL))-induced Porcine Granulosa Cell Apoptosis
[作者：Wang, XL; Wu, Y; Tan, LB; Tian, Z; Liu, JH; Zhu, DS; Zeng, SM,期刊：Journal of Biological Chemistry, 页码：10166-10177 , 文章类型： Article，,卷期：2012年287-13]
- The pro-apoptotic protein Bim (B-cell lymphoma-2 (Bcl-2)-interacting modulator of cell death) has recently been identified and shown to promote cell death in response to several stimuli. In this report, we investigated t...
- MicroRNA-29a Inhibited Epididymal Epithelial Cell Proliferation by Targeting Nuclear Autoantigenic Sperm Protein (NASP)
[作者：Ma, WB; Xie, SS; Ni, MJ; Huang, XX; Hu, SG; Liu, Q; Liu, AH; Zhang, JS; Zhang, YL,期刊：Journal of Biological Chemistry, 页码：10189-10199 , 文章类型： Article，,卷期：2012年287-13]
- Cell proliferation often decreases gradually during postnatal development of some organs. However, the underlying molecular mechanisms remain unclear. Epididymis, playing important roles in sperm maturation, is a typical...
- Curcumin Suppresses T Cell Activation by Blocking Ca2+ Mobilization and Nuclear Factor of Activated T Cells (NFAT) Activation
[作者：Kliem, C; Merling, A; Giaisi, M; Kohler, R; Krammer, PH; Li-Weber, M,期刊：Journal of Biological Chemistry, 页码：10200-10209 , 文章类型： Article，,卷期：2012年287-13]
- Curcumin is the active ingredient of the spice turmeric and has been shown to have a number of pharmacologic and therapeutic activities including antioxidant, anti-microbial, anti-inflammatory, and anti-carcinogenic prop...
- Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC)
[作者：Aleshin, AE; Schraufstatter, IU; Stec, B; Bankston, LA; Liddington, RC; DiScipio, RG,期刊：Journal of Biological Chemistry, 页码：10210-10222 , 文章类型： Article，,卷期：2012年287-13]
- The complement membrane attack complex (MAC) is formed by the sequential assembly of C5b with four homologous proteins as follows: one copy each of C6, C7, and C8 and 12-14 copies of C9. Together these form a lytic pore ...
- Interaction with ErbB4 Promotes Hypoxia-inducible Factor-1 alpha Signaling
[作者：Paatero, I; Jokilammi, A; Heikkinen, PT; Iljin, K; Kallioniemi, OP; Jones, FE; Jaakkola, PM; Elenius, K,期刊：Journal of Biological Chemistry, 页码：9659-9671 , 文章类型： Article，,卷期：2012年287-13]
- The receptor-tyrosine kinase ErbB4 was identified as a direct regulator of hypoxia-inducible factor-1 alpha (HIF-1 alpha) signaling. Cleaved intracellular domain of ErbB4 directly interacted with HIF-1 alpha in the nucle...
- Discovery of Marinopyrrole A (Maritoclax) as a Selective Mcl-1 Antagonist that Overcomes ABT-737 Resistance by Binding to and Targeting Mcl-1 for Proteasomal Degradation
[作者：Doi, K; Li, RS; Sung, SS; Wu, HW; Liu, Y; Manieri, W; Krishnegowda, G; Awwad, A; Dewey, A; Liu, X; Amin, S; Cheng, CW; Qin, Y; Schonbrunn, E; Daughdrill, G; Loughran, TP; Sebti, S; Wang, HG,期刊：Journal of Biological Chemistry, 页码：10224-10235 , 文章类型： Article，,卷期：2012年287-13]
- The anti-apoptotic Bcl-2 family of proteins, including Bcl-2, Bcl-X-L and Mcl-1, are well-validated drug targets for cancer treatment. Several small molecules have been designed to interfere with Bcl-2 and its fellow pro...
- Inhibitors of V-ATPase Proton Transport Reveal Uncoupling Functions of Tether Linking Cytosolic and Membrane Domains of V-0 Subunit a (Vph1p)
[作者：Chan, CY; Prudom, C; Raines, SM; Charkhzarrin, S; Melman, SD; De Haro, LP; Allen, C; Lee, SA; Sklar, LA; Parra, KJ,期刊：Journal of Biological Chemistry, 页码：10236-10250 , 文章类型： Article，,卷期：2012年287-13]
- Vacuolar ATPases (V-ATPases) are important for many cellular processes, as they regulate pH by pumping cytosolic protons into intracellular organelles. The cytoplasm is acidified when V-ATPase is inhibited; thus we condu...
- Controlling Lipid Fluxes at Glycerol-3-phosphate Acyltransferase Step in Yeast UNIQUE CONTRIBUTION OF Gat1p TO OLEIC ACID-INDUCED LIPID PARTICLE FORMATION
[作者：Marr, N; Foglia, J; Terebiznik, M; Athenstaedt, K; Zaremberg, V,期刊：Journal of Biological Chemistry, 页码：10251-10264 , 文章类型： Article，,卷期：2012年287-13]
- The ability to channel excess fatty acids into neutral lipids like triacylglycerol (TAG) is a critical strategy used by cells to maintain lipid homeostasis. Upon activation to acyl-CoA, fatty acids become readily availab...
- Proteome of Hydra Nematocyst
[作者：Balasubramanian, PG; Beckmann, A; Warnken, U; Schnolzer, M; Schuler, A; Bornberg-Bauer, E; Holstein, TW; Ozbek, S,期刊：Journal of Biological Chemistry, 页码：9672-9681 , 文章类型： Article，,卷期：2012年287-13]
- Stinging cells or nematocytes of jellyfish and other cnidarians represent one of the most poisonous and sophisticated cellular inventions in animal evolution. This ancient cell type is unique in containing a giant secret...
- Cloning and Characterization of CD300d, a Novel Member of the Human CD300 Family of Immune Receptors
[作者：Comas-Casellas, E; Martinez-Barriocanal, A; Miro, F; Ejarque-Ortiz, A; Schwartz, S; Martin, M; Sayos, J,期刊：Journal of Biological Chemistry, 页码：9682-9693 , 文章类型： Article，,卷期：2012年287-13]
- Herein we present the cloning and molecular characterization of CD300d, a member of the human CD300 family of immune receptors. CD300d cDNA was cloned from RNA obtained from human peripheral blood mononuclear cells, and ...
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