- CNS depressant and anticonvulsant activities of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones
[作者:Jatav, V; Mishra, P; Kashaw, S; Stables, JP,期刊:European Journal of Medicinal Chemistry, 页码:1945-1954 , 文章类型: Article,,卷期:2008年43-9]
A series of new 3-[5-substituted phenyl-1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones were synthesized and evaluated for anticonvulsant, sedative-hypnotic and CNS depression activities. After i.p. injection ...
- Microwave induced synthesis of novel 8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepines as potential antitumor agents
[作者:Insuasty, B; Orozco, F; Quiroga, J; Abonia, R; Nogueras, M; Cobo, J,期刊:European Journal of Medicinal Chemistry, 页码:1955-1962 , 文章类型: Article,,卷期:2008年43-9]
A series of new racemic 4-amino-6-aryi-8-(1,3-benzodioxol-5-yl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepines 4a-f and 4-amino-8-aryl6-(1,3-benzodioxol-5-yl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepines 5a-f were obt...
- In vitro and in vivo investigations on the antiviral activity of a series of mixed-valence rare earth borotungstate heteropoly blues
[作者:Liu, YN; Shi, S; Mei, WJ; Tan, CP; Chen, LM; Liu, J; Zheng, WJ; Ji, LN,期刊:European Journal of Medicinal Chemistry, 页码:1963-1970 , 文章类型: Article,,卷期:2008年43-9]
A series of mixed-valence rare earth borotungsto-heteropoly blues, K15H2, [Ln(BW9W2O39)2]-28H(2)O (Ln(2), Ln = La, Ce, Pr, Nd, Sm, Eu, Gd), have been prepared and characterized by IR, UV, XPS, ESR and electrochemistry...
- Selenium containing heterocycles: Synthesis, anti-inflammatory, analgesic and anti-microbial activities of some new 4-cyanopyridazine-3(2H)selenone derivatives
[作者:Abdel-Hafez, SH,期刊:European Journal of Medicinal Chemistry, 页码:1971-1977 , 文章类型: Article,,卷期:2008年43-9]
New series of selenolo[2,3-c]pyridazine and pyrimido[4',5':4,5]selenolo[2,3-c] pyridazine derivatives were prepared from new 4-cyano-5,6diphenylpyridazine-3(2H)selenone (2). Elemental analysis, IR, H-1 NMR, C-13 NMR a...
- Synthesis of new 4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems: A novel class of potential antibacterial and antitubercular agents
[作者:Joshi, SD; Vagdevi, HM; Vaidya, VP; Gadaginamath, GS,期刊:European Journal of Medicinal Chemistry, 页码:1989-1996 , 文章类型: Article,,卷期:2008年43-9]
In the present study, a novel series of 4-pyrrol-l-yl benzoic acid hydrazide analogs, some derived 5-substituted-2-thiol-1,3,4-oxadiazoles, 5-substituted-4-amino-1,2,4-triazolin-3-thione and 2,5-dimethyl pyrroles have...
- Synthesis, antileukemic and antiplatelet activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines
[作者:Ramajayam, R; Giridhar, R; Yadav, MR; Balaraman, R; Djaballah, H; Shum, D; Radu, C,期刊:European Journal of Medicinal Chemistry, 页码:2004-2010 , 文章类型: Article,,卷期:2008年43-9]
The synthesis, antileukemic and antiplatelet activity evaluation of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines are described. In general, it was found that compound 17o showed moderate antileukemic activity against MOLT...
- 1,2,3,4-Tetrahydro-2-thioxopyrimidine analogs of combretastatin-A4
[作者:Lee, L; Davis, R; Vanderham, J; Hills, P; Mackay, H; Brown, T; Mooberry, SL; Lee, M,期刊:European Journal of Medicinal Chemistry, 页码:2011-2015 , 文章类型: Article,,卷期:2008年43-9]
Eleven 1,2,3,4-tetrahydro-2-thioxopyrimidine analogs of combretastatin-A4 (CA-4) were synthesized and their cytotoxicity against the growth of two murine cancer cell lines (B16 melanoma and L1210 leukemia) in culture ...
- Synthesis and in vitro antibacterial activity of new steroidal thiosemicarbazone derivatives
[作者:Khan, SA; Kumar, P; Joshi, R; Iqbal, PF; Saleem, K,期刊:European Journal of Medicinal Chemistry, 页码:2029-2034 , 文章类型: Article,,卷期:2008年43-9]
We investigated the antibacterial activity of some new steroidal thiosemicarbazone derivatives, prepared from the reaction of cholest-5-en-7-one with thiosemicarbazides, in ethanol in the presence of a few drops of HC...
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