- 20-Hydroxylation is the CYP-dependent and retinoid-inducible leukotriene B4 inactivation pathway in human and mouse skin cells
[作者:Du, L; Yin, H; Morrow, JD; Strobel, HW; Keeney, DS,期刊:Archives of Biochemistry and Biophysics , 页码:80-86 , 文章类型: Article,,卷期:2009年484-1]
- Metabolic inactivation of leukotriene B4 (LTB4) is an innate mechanism to resolve tissue inflammation. We studied the nine Cyp4f genes in the mouse genome, measuring cutaneous transcript levels by real-time polymerase ch...
- Neuromelanins in various regions of human brain are associated with native and oxidized isoprenoid lipids
[作者:Ward, WC; Zucca, FA; Bellei, C; Zecca, L; Simon, JD,期刊:Archives of Biochemistry and Biophysics , 页码:94-99 , 文章类型: Article,,卷期:2009年484-1]
- Neuromelanin (NM) isolated from seven regions of the human brain is found to contain series of natural and oxidized isoprenoid lipids. Specifically, dolichols (dol) and dolichoic acids (dol-CA) with 14-22 and 14-21 isopr...
- The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury
[作者:Vafeiadou, K; Vauzour, D; Lee, HY; Rodriguez-Mateos, A; Williams, RJ; Spencer, JPE,期刊:Archives of Biochemistry and Biophysics , 页码:100-109 , 文章类型: Article,,卷期:2009年484-1]
- Neuroinflammation plays an integral role in the progression of neurodegeneration. In this study we investigated the anti-inflammatory effects of different classes of flavonoids (flavanones, flavanols and anthocyanidins) ...
- Characterization of inhibitor binding to human kinesin spindle protein by site-directed mutagenesis
[作者:Marshall, CG; Torrent, M; Williams, O; Hamilton, KA; Buser, CA,期刊:Archives of Biochemistry and Biophysics , 页码:1-7 , 文章类型: Article,,卷期:2009年484-1]
- A number of inhibitors of kinesin spindle protein (KSP) have been described, which are known from X-ray crystallography Studies to bind to an induced fit pocket defined by the L5 loop. We describe the characterization of...
- The pH dependence of the allosteric response of human liver pyruvate kinase to fructose-1,6-bisphosphate, ATP, and alanine
[作者:Fenton, AW; Hutchinson, M,期刊:Archives of Biochemistry and Biophysics , 页码:16-23 , 文章类型: Article,,卷期:2009年484-1]
- The allosteric regulation of human liver pyruvate kinase (hL-PYK) by fructose-1,6-bisphosphate (Fru-1,6-BP: activator), ATP (inhibitor) and alanine; (Ala; inhibitor) was monitored over a pH range from 6.5 to 8.0 at 37 de...
- DSA affinity glycoproteome of human liver tissue
[作者:Sun, QL; Kang, XN; Zhang, Y; Zhou, HJ; Dai, Z; Lu, WJ; Zhou, XW; Liu, XH; Yang, PY; Liu, YK,期刊:Archives of Biochemistry and Biophysics , 页码:24-29 , 文章类型: Article,,卷期:2009年484-1]
- Due to the critical roles of glycoproteins in the activities of cells to tissues, mapping of liver glycoproteome may provide valuable basic information for finding disease marker proteins. In this study, Datura Stramoniu...
- Arabidopsis thaliana PRP40s are RNA polymerase II C-terminal domain-associating proteins
[作者:Kang, CH; Feng, Y; Vikram, M; Jeong, IS; Lee, JR; Bahk, JD; Yun, DJ; Lee, SY; Koiwa, H,期刊:Archives of Biochemistry and Biophysics , 页码:30-38 , 文章类型: Article,,卷期:2009年484-1]
- The carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II functions as a scaffold for RNA processing machineries that recognize differentially phosphorylated conserved (YSPTSPS), repeats. Evidence in...
- Development, evaluation and application of tripeptidyl-peptidase II sequence signatures
[作者:Eriksson, S; Gutierrez, OA; Bjerling, P; Tomkinson, B,期刊:Archives of Biochemistry and Biophysics , 页码:39-45 , 文章类型: Article,,卷期:2009年484-1]
- Tripepticlyl-peptidase II (TPP II) is a cytosolic peptidase that has been implicated in fat formation and cancer, apparently independent of the enzymatic activity. In search for alternative functional regions, conserved ...
- A conserved hydrophobic core at Bcl-x(L) mediates its structural stability and binding affinity with BH3-domain peptide of pro-apoptotic protein
[作者:Feng, Y; Zhang, L; Hu, TC; Shen, X; Ding, JP; Chen, KX; Jiang, HL; Liu, DX,期刊:Archives of Biochemistry and Biophysics , 页码:46-54 , 文章类型: Article,,卷期:2009年484-1]
- Bcl-2 family proteins regulate apoptosis through their homo- and heterodimerization. By protein sequence analysis and structural comparison, we have identified a conserved hydrophobic core at the BH1 and BH2 domains of B...
- Evidence for a distinct ligand binding site on tubulin discovered through inhibition by GDP of paclitaxel-induced tubulin assembly in the absence of exogenous GTP
[作者:Wilcox, E; McGrath, C; Blokhin, AV; Gussio, R; Hamel, E,期刊:Archives of Biochemistry and Biophysics , 页码:55-62 , 文章类型: Article,,卷期:2009年484-1]
- GDP inhibits paclitaxel-induced tubulin assembly without GTP when the tubulin bears GDP in the exchangeable site (E-site). initially, we thought inhibition was mediated through the E-site, since small amounts of GTP or M...
- Proton flux induced by free fatty acids across phospholipid bilayers: New evidences based on short-circuit measurements in planar lipid membranes
[作者:Arcisio-Miranda, M; Abdulkader, F; Brunaldi, K; Curi, R; Procopio, J,期刊:Archives of Biochemistry and Biophysics , 页码:63-69 , 文章类型: Article,,卷期:2009年484-1]
- Free fatty acids (FFA) are important mediators of proton transport across membranes. However, information concerning the influence of the Structural features of both FFA and the membrane environment on the proton translo...
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