- CaMKII binding to GluN2B is critical during memory consolidation
[作者：Halt, AR; Dallapiazza, RF; Zhou, Y; Stein, IS; Qian, H; Juntti, S; Wojcik, S; Brose, N; Silva, AJ; Hell, JW,期刊：EMBO journal, 页码：1203-1216 , 文章类型： Article，,卷期：2012年31-5]
- Memory is essential for our normal daily lives and our sense of self. Ca2+ influx through the NMDA-type glutamate receptor (NMDAR) and the ensuing activation of the Ca2+ and calmodulin-dependent protein kinase (CaMKII) a...
- Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning
[作者：Seja, P; Schonewille, M; Spitzmaul, G; Badura, A; Klein, I; Rudhard, Y; Wisden, W; Hubner, CA; De Zeeuw, CI; Jentsch, TJ,期刊：EMBO journal, 页码：1217-1230 , 文章类型： Article，,卷期：2012年31-5]
- Cerebellar cortical throughput involved in motor control comprises granule cells (GCs) and Purkinje cells (PCs), both of which receive inhibitory GABAergic input from interneurons. The GABAergic input to PCs is essential...
- Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism
[作者：Antonucci, F; Turola, E; Riganti, L; Caleo, M; Gabrielli, M; Perrotta, C; Novellino, L; Clementi, E; Giussani, P; Viani, P; Matteoli, M; Verderio, C,期刊：EMBO journal, 页码：1231-1240 , 文章类型： Article，,卷期：2012年31-5]
- Microvesicles (MVs) released into the brain microenvironment are emerging as a novel way of cell-to-cell communication. We have recently shown that microglia, the immune cells of the brain, shed MVs upon activation but t...
- Genetic evidence of a redox-dependent systemic wound response via Hayan Protease-Phenoloxidase system in Drosophila
[作者：Nam, HJ; Jang, IH; You, H; Lee, KA; Lee, WJ,期刊：EMBO journal, 页码：1253-1265 , 文章类型： Article，,卷期：2012年31-5]
- Systemic wound response (SWR) through intertissue communication in response to local wounds is an essential biological phenomenon that occurs in all multicellular organisms from plants to animals. However, our understand...
- Rsk-mediated phosphorylation and 14-3-3 epsilon binding of Apaf-1 suppresses cytochrome c-induced apoptosis
[作者：Kim, J; Parrish, AB; Kurokawa, M; Matsuura, K; Freel, CD; Andersen, JL; Johnson, CE; Kornbluth, S,期刊：EMBO journal, 页码：1279-1292 , 文章类型： Article，,卷期：2012年31-5]
- Many pro-apoptotic signals trigger mitochondrial cytochrome c release, leading to caspase activation and ultimate cellular breakdown. Cell survival pathways, including the mitogen-activated protein kinase (MAPK) cascade,...
- Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly
[作者：Hornig-Do, HT; Tatsuta, T; Buckermann, A; Bust, M; Kollberg, G; Rotig, A; Hellmich, M; Nijtmans, L; Wiesner, RJ,期刊：EMBO journal, 页码：1293-1307 , 文章类型： Article，,卷期：2012年31-5]
- Respiratory chain (RC) complexes are organized into supercomplexes forming 'respirasomes'. The mechanism underlying the interdependence of individual complexes is still unclear. Here, we show in human patient cells that ...
- Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin
[作者：Mukherjee, M; Chow, SY; Yusoff, P; Seetharaman, J; Ng, C; Sinniah, S; Koh, XW; Asgar, NFM; Li, D; Yim, D; Jackson, RA; Yew, J; Qian, JR; Iyu, A; Lim, YP; Zhou, XD; Sze, SK; Guy, GR; Sivaraman, J,期刊：EMBO journal, 页码：1308-1319 , 文章类型： Article，,卷期：2012年31-5]
- Phosphotyrosine-binding domains, typified by the SH2 (Src homology 2) and PTB domains, are critical upstream components of signal transduction pathways. The E3 ubiquitin ligase Hakai targets tyrosine-phosphorylated E-cad...
- A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death
[作者：Garg, AD; Krysko, DV; Verfaillie, T; Kaczmarek, A; Ferreira, GB; Marysael, T; Rubio, N; Firczuk, M; Mathieu, C; Roebroek, AJM; Annaert, W; Golab, J; de Witte, P; Vandenabeele, P; Agostinis, P,期刊：EMBO journal, 页码：1062-1079 , 文章类型： Article，,卷期：2012年31-5]
- Surface-exposed calreticulin (ecto-CRT) and secreted ATP are crucial damage-associated molecular patterns (DAMPs) for immunogenic apoptosis. Inducers of immunogenic apoptosis rely on an endoplasmic reticulum (ER)based (r...
- Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation
[作者：Barascu, A; Le Chalony, C; Pennarun, G; Genet, D; Imam, N; Lopez, B; Bertrand, P,期刊：EMBO journal, 页码：1080-1094 , 文章类型： Article，,卷期：2012年31-5]
- We report crosstalk between three senescence-inducing conditions, DNA damage response (DDR) defects, oxidative stress (OS) and nuclear shape alterations. The recessive autosomal genetic disorder Ataxia telangiectasia (A-...
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
[作者：Settembre, C; Zoncu, R; Medina, DL; Vetrini, F; Erdin, S; Erdin, S; Huynh, T; Ferron, M; Karsenty, G; Vellard, MC; Facchinetti, V; Sabatini, DM; Ballabio, A,期刊：EMBO journal, 页码：1095-1108 , 文章类型： Article，,卷期：2012年31-5]
- The lysosome plays a key role in cellular homeostasis by controlling both cellular clearance and energy production to respond to environmental cues. However, the mechanisms mediating lysosomal adaptation are largely unkn...
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