- MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis
[作者:Hosono, Y; Yamaguchi, T; Mizutani, E; Yanagisawa, K; Arima, C; Tomida, S; Shimada, Y; Hiraoka, M; Kato, S; Yokoi, K; Suzuki, M; Takahashi, T,期刊:EMBO journal, 页码:481-493 , 文章类型: Article,,卷期:2012年31-2]
- Cell migration driven by actomyosin filament assembly is a critical step in tumour invasion and metastasis. Herein, we report identification of myosin binding protein H (MYBPH) as a transcriptional target of TTF-1 (also ...
- Extracellular matrix players in metastatic niches
[作者:Oskarsson, T; Massague, J,期刊:EMBO journal, 页码:254-256 , 文章类型: Editorial Material,,卷期:2012年31-2]
- Metastatic niches support the survival and fitness of disseminated tumour cells (DTCs) in otherwise inhospitable tissue environments. The components of metastatic niches have remained a matter of conjecture, but recent r...
- Extraordinary transgressive phenotypes of hybrid tomato are influenced by epigenetics and small silencing RNAs
[作者:Shivaprasad, PV; Dunn, RM; Santos, BACM; Bassett, A; Baulcombe, DC,期刊:EMBO journal, 页码:257-266 , 文章类型: Article,,卷期:2012年31-2]
- Hybrid organisms may fail to develop, be sterile or they may be more vigorous than either of the parents. Examples of hybrid vigour or hybrid necrosis in the F1 are often not inherited stably in subsequent generations if...
- The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex
[作者:Fromm, SA; Truffault, V; Kamenz, J; Braun, JE; Hoffmann, NA; Izaurralde, E; Sprangers, R,期刊:EMBO journal, 页码:279-290 , 文章类型: Article,,卷期:2012年31-2]
- The Dcp1:Dcp2 decapping complex catalyses the removal of the mRNA 5' cap structure. Activator proteins, including Edc3 (enhancer of decapping 3), modulate its activity. Here, we solved the structure of the yeast Edc3 LSm...
- Signal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex
[作者:Forcales, SV; Albini, S; Giordani, L; Malecova, B; Cignolo, L; Chernov, A; Coutinho, P; Saccone, V; Consalvi, S; Williams, R; Wang, KP; Wu, ZG; Baranovskaya, S; Miller, A; Dilworth, FJ; Puri, PL,期刊:EMBO journal, 页码:301-316 , 文章类型: Article,,卷期:2012年31-2]
- Tissue-specific transcriptional activators initiate differentiation towards specialized cell types by inducing chromatin modifications permissive for transcription at target loci, through the recruitment of SWItch/Sucros...
- An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment
[作者:Lynch, MD; Smith, AJH; De Gobbi, M; Flenley, M; Hughes, JR; Vernimmen, D; Ayyub, H; Sharpe, JA; Sloane-Stanley, JA; Sutherland, L; Meek, S; Burdon, T; Gibbons, RJ; Garrick, D; Higgs, DR,期刊:EMBO journal, 页码:317-329 , 文章类型: Article,,卷期:2012年31-2]
- The role of DNA sequence in determining chromatin state is incompletely understood. We have previously demonstrated that large chromosomal segments from human cells recapitulate their native chromatin state in mouse cell...
- Human tRNA genes function as chromatin insulators
[作者:Raab, JR; Chiu, J; Zhu, JC; Katzman, S; Kurukuti, S; Wade, PA; Haussler, D; Kamakaka, RT,期刊:EMBO journal, 页码:330-350 , 文章类型: Article,,卷期:2012年31-2]
- Insulators help separate active chromatin domains from silenced ones. In yeast, gene promoters act as insulators to block the spread of Sir and HP1 mediated silencing while in metazoans most insulators are multipartite a...
- FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors
[作者:Mancini, E; Sanjuan-Pla, A; Luciani, L; Moore, S; Grover, A; Zay, A; Rasmussen, KD; Luc, S; Bilbao, D; O'Carroll, D; Jacobsen, SE; Nerlov, C,期刊:EMBO journal, 页码:351-365 , 文章类型: Article,,卷期:2012年31-2]
- The transcription factors that control lineage specification of haematopoietic stem cells (HSCs) have been well described for the myeloid and lymphoid lineages, whereas transcriptional control of erythroid (E) and megaka...
- Coreceptor gene imprinting governs thymocyte lineage fate
[作者:Adoro, S; McCaughtry, T; Erman, B; Alag, A; Van Laethem, F; Park, JH; Tai, XG; Kimura, M; Wang, L; Grinberg, A; Kubo, M; Bosselut, R; Love, P; Singer, A,期刊:EMBO journal, 页码:366-377 , 文章类型: Article,,卷期:2012年31-2]
- Immature thymocytes are bipotential cells that are signalled during positive selection to become either helper- or cytotoxic-lineage T cells. By tracking expression of lineage determining transcription factors during pos...
- Synthetic biology approach to reconstituting the ubiquitylation cascade in bacteria
[作者:Keren-Kaplan, T; Attali, I; Motamedchaboki, K; Davis, BA; Tanner, N; Reshef, Y; Laudon, E; Kolot, M; Levin-Kravets, O; Kleifeld, O; Glickman, M; Horazdovsky, BF; Wolf, DA; Prag, G,期刊:EMBO journal, 页码:378-390 , 文章类型: Article,,卷期:2012年31-2]
- Covalent modification of proteins with ubiquitin (Ub) is widely implicated in the control of protein function and fate. Over 100 deubiquitylating enzymes rapidly reverse this modification, posing challenges to the bioche...
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