- Nuclear Extracellular Signal-Regulated Kinase 1 and 2 Translocation Is Mediated by Casein Kinase 2 and Accelerated by Autophosphorylation
[作者:Plotnikov, A; Chuderland, D; Karamansha, Y; Livnah, O; Seger, R,期刊:Molecular and Cellular Biology, 页码:3515-3530 , 文章类型: Article,,卷期:2011年31-17]
- The extracellular signal-regulated kinases (ERK) 1 and 2 (ERK1/2) are members of the mitogen-activated protein kinase [MAPK] family. Upon stimulation, these kinases translocate from the cytoplasm to the nucleus, where th...
- Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels
[作者:Mungai, PT; Waypa, GB; Jairaman, A; Prakriya, M; Dokic, D; Ball, MK; Schumacker, PT,期刊:Molecular and Cellular Biology, 页码:3531-3545 , 文章类型: Article,,卷期:2011年31-17]
- AMP-activated protein kinase ( AMPK) is an energy sensor activated by increases in [AMP] or by oxidant stress (reactive oxygen species [ROS]). Hypoxia increases cellular ROS signaling, but the pathways underlying subsequ...
- Hypoxia Leads to Na,K-ATPase Downregulation via Ca2+ Release-Activated Ca2+ Channels and AMPK Activation
[作者:Gusarova, GA; Trejo, HE; Dada, LA; Briva, A; Welch, LC; Hamanaka, RB; Mutlu, GM; Chandel, NS; Prakriya, M; Sznajder, JI,期刊:Molecular and Cellular Biology, 页码:3546-3556 , 文章类型: Article,,卷期:2011年31-17]
- To maintain cellular ATP levels, hypoxia leads to Na,K-ATPase inhibition in a process dependent on reactive oxygen species (ROS) and the activation of AMP-activated kinase alpha 1 (AMPK-alpha 1). We report here that duri...
- H3K4 Trimethylation by Set1 Promotes Efficient Termination by the Nrd1-Nab3-Sen1 Pathway
[作者:Terzi, N; Churchman, LS; Vasiljeva, L; Weissman, J; Buratowski, S,期刊:Molecular and Cellular Biology, 页码:3569-3583 , 文章类型: Article,,卷期:2011年31-17]
- In Saccharomyces cerevisiae, the Nrd1-Nab3-Sen1 pathway mediates the termination of snoRNAs and cryptic unstable transcripts (CUTs). Both Nrd1 and the Set1 histone H3K4 methyltransferase complex interact with RNA polymer...
- MICAL-1 Is a Negative Regulator of MST-NDR Kinase Signaling and Apoptosis
[作者:Zhou, YP; Adolfs, Y; Pijnappel, WWMP; Fuller, SJ; Van der Schors, RC; Li, KW; Sugden, PH; Smit, AB; Hergovich, A; Pasterkamp, RJ,期刊:Molecular and Cellular Biology, 页码:3603-3615 , 文章类型: Article,,卷期:2011年31-17]
- MICALs (molecules interacting with CasL) are atypical multidomain flavoenzymes with diverse cellular functions. The molecular pathways employed by MICAL proteins to exert their cellular effects remain largely uncharacter...
- PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment
[作者:Avivar-Valderas, A; Salas, E; Bobrovnikova-Marjon, E; Diehl, JA; Nagi, C; Debnath, J; Aguirre-Ghiso, JA,期刊:Molecular and Cellular Biology, 页码:3616-3629 , 文章类型: Article,,卷期:2011年31-17]
- Mammary epithelial cells (MECs) detached from the extracellular matrix (ECM) produce deleterious reactive oxygen species (ROS) and induce autophagy to survive. The coordination of such opposing responses likely dictates ...
- Regulation of Androgen Receptor-Mediated Transcription by RPB5 Binding Protein URI/RMP
[作者:Mita, P; Savas, JN; Djouder, N; Yates, JR; Ha, S; Ruoff, R; Schafler, ED; Nwachukwu, JC; Tanese, N; Cowan, NJ; Zavadil, J; Garabedian, MJ; Logan, SK,期刊:Molecular and Cellular Biology, 页码:3639-3652 , 文章类型: Article,,卷期:2011年31-17]
- Androgen receptor (AR)-mediated transcription is modulated by interaction with coregulatory proteins. We demonstrate that the unconventional prefoldin RPB5 interactor (URI) is a new regulator of AR transcription and is c...
- 1,25-Dihydroxyvitamin D-3 Ameliorates Th17 Autoimmunity via Transcriptional Modulation of Interleukin-17A
[作者:Joshi, S; Pantalena, LC; Liu, XK; Gaffen, SL; Liu, H; Rohowsky-Kochan, C; Ichiyama, K; Yoshimura, A; Steinman, L; Christakos, S; Youssef, S,期刊:Molecular and Cellular Biology, 页码:3653-3669 , 文章类型: Article,,卷期:2011年31-17]
- A new class of inflammatory CD4(+) T cells that produce interleukin-17 (IL-17) (termed Th17) has been identified, which plays a critical role in numerous inflammatory conditions and autoimmune diseases. The active form o...
- Inhibition of Nonsense-Mediated RNA Decay by the Tumor Microenvironment Promotes Tumorigenesis
[作者:Wang, D; Zavadil, J; Martin, L; Parisi, F; Friedman, E; Levy, D; Harding, H; Ron, D; Gardner, LB,期刊:Molecular and Cellular Biology, 页码:3670-3680 , 文章类型: Article,,卷期:2011年31-17]
- While nonsense-mediated RNA decay (NMD) is an established mechanism to rapidly degrade select transcripts, the physiological regulation and biological significance of NMD are not well characterized. We previously demonst...
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