- Human Epidermal Growth Factor Receptor (EGFR) Aligned on the Plasma Membrane Adopts Key Features of Drosophila EGFR Asymmetry
[作者:Tynan, CJ; Roberts, SK; Rolfe, DJ; Clarke, DT; Loeffler, HH; Kastner, J; Winn, MD; Parker, PJ; Martin-Fernandez, ML,期刊:Molecular and Cellular Biology, 页码:2241-2252 , 文章类型: Article,,卷期:2011年31-11]
- The ability of epidermal growth factor receptor (EGFR) to control cell fate is defined by its affinity for ligand. Current models suggest that ligand-binding heterogeneity arises from negative cooperativity in signaling ...
- Characterization of the Mechanisms Controlling Greatwall Activity
[作者:Vigneron, S; Gharbi-Ayachi, A; Raymond, AA; Burgess, A; Labbe, JC; Labesse, G; Monsarrat, B; Lorca, T; Castro, A,期刊:Molecular and Cellular Biology, 页码:2262-2275 , 文章类型: Article,,卷期:2011年31-11]
- Here we investigate the mechanisms regulating Greatwall (Gwl), a serine/threonine kinase essential for promoting the correct timing of mitosis. We identify Gwl as a unique AGC kinase that, unlike most AGC members, appear...
- Lack of Protein 4.1G Causes Altered Expression and Localization of the Cell Adhesion Molecule Nectin-Like 4 in Testis and Can Cause Male Infertility
[作者:Yang, SM; Weng, HB; Chen, LX; Guo, XH; Parra, M; Conboy, J; Debnath, G; Lambert, AJ; Peters, LL; Baines, AJ; Mohandas, N; An, XL,期刊:Molecular and Cellular Biology, 页码:2276-2286 , 文章类型: Article,,卷期:2011年31-11]
- Protein 4.1G is a member of the protein 4.1 family, which in general serves as adaptors linking transmembrane proteins to the cytoskeleton. 4.1G is thought to be widely expressed in many cells and tissues, but its functi...
- A Novel Transcription Complex That Selectively Modulates Apoptosis of Breast Cancer Cells through Regulation of FASTKD2
[作者:Yeung, KT; Das, S; Zhang, J; Lomniczi, A; Ojeda, SR; Xu, CF; Neubert, TA; Samuels, HH,期刊:Molecular and Cellular Biology, 页码:2287-2298 , 文章类型: Article,,卷期:2011年31-11]
- We previously reported that expression of NRIF3 (nuclear receptor interacting factor-3) rapidly and selectively leads to apoptosis of breast cancer cells. DIF-1 (also known as interferon regulatory factor-2 binding prote...
- DNA Repair and Global Sumoylation Are Regulated by Distinct Ubc9 Noncovalent Complexes
[作者:Prudden, J; Perry, JJP; Nie, MH; Vashisht, AA; Arvai, AS; Hitomi, C; Guenther, G; Wohlschlegel, JA; Tainer, JA; Boddy, MN,期刊:Molecular and Cellular Biology, 页码:2299-2310 , 文章类型: Article,,卷期:2011年31-11]
- Global sumoylation, SUMO chain formation, and genome stabilization are all outputs generated by a limited repertoire of enzymes. Mechanisms driving selectivity for each of these processes are largely uncharacterized. Her...
- A Conserved Patch near the C Terminus of Histone H4 Is Required for Genome Stability in Budding Yeast
[作者:Yu, Y; Srinivasan, M; Nakanishi, S; Leatherwood, J; Shilatifard, A; Sternglanz, R,期刊:Molecular and Cellular Biology, 页码:2311-2325 , 文章类型: Article,,卷期:2011年31-11]
- A screen of Saccharomyces cerevisiae histone alanine substitution mutants revealed that mutations in any of three adjacent residues, L97, Y98, or G99, near the C terminus of H4 led to a unique phenotype. The mutants grew...
- Cysteine 27 Variant of the delta-Opioid Receptor Affects Amyloid Precursor Protein Processing through Altered Endocytic Trafficking
[作者:Sarajarvi, T; Tuusa, JT; Haapasalo, A; Lackman, JJ; Sormunen, R; Helisalmi, S; Roehr, JT; Parrado, AR; Makinen, P; Bertram, L; Soininen, H; Tanzi, RE; Petaja-Repo, UE; Hiltunen, M,期刊:Molecular and Cellular Biology, 页码:2326-2340 , 文章类型: Article,,卷期:2011年31-11]
- Agonist-induced activation of the delta-opioid receptor (delta OR) was recently shown to augment beta- and gamma-secretase activities, which increased the production of beta-amyloid peptide (A beta), known to accumulate ...
- Acetylation of a Conserved Lysine Residue in the ATP Binding Pocket of p38 Augments Its Kinase Activity during Hypertrophy of Cardiomyocytes
[作者:Pillai, VB; Sundaresan, NR; Samant, SA; Wolfgeher, D; Trivedi, CM; Gupta, MP,期刊:Molecular and Cellular Biology, 页码:2349-2363 , 文章类型: Article,,卷期:2011年31-11]
- Like phosphorylation, acetylation of lysine residues within a protein is considered a biologically relevant modification that controls the activity of target proteins. During stress of cells, massive protein acetylation ...
- Signal- and Development-Dependent Alternative Splicing of LEF1 in T Cells Is Controlled by CELF2
[作者:Mallory, MJ; Jackson, J; Weber, B; Chi, A; Heyd, F; Lynch, KW,期刊:Molecular and Cellular Biology, 页码:2184-2195 , 文章类型: Article,,卷期:2011年31-11]
- The HMG-box transcription factor LEF1 controls many developmentally regulated genes, including genes that activate expression of the T-cell antigen receptor alpha chain (TCR-alpha) in developing thymocytes. At least two ...
- Genome-Wide Approaches Reveal Functional Interleukin-4-Inducible STAT6 Binding to the Vascular Cell Adhesion Molecule 1 Promoter
[作者:Tozawa, H; Kanki, Y; Suehiro, J; Tsutsumi, S; Kohro, T; Wada, Y; Aburatani, H; Aird, WC; Kodama, T; Minami, T,期刊:Molecular and Cellular Biology, 页码:2196-2209 , 文章类型: Article,,卷期:2011年31-11]
- Endothelial cell activation and dysfunction underlie many vascular disorders, including atherosclerosis and inflammation. Here, we show that interleukin-4 (IL-4) markedly induced vascular cell adhesion molecule 1 (VCAM-1...
- I kappa B Kinase beta Promotes Cell Survival by Antagonizing p53 Functions through Delta Np73 alpha Phosphorylation and Stabilization
[作者:Accardi, R; Scalise, M; Gheit, T; Hussain, I; Yue, JP; Carreira, C; Collino, A; Indiveri, C; Gissmann, L; Sylla, BS; Tommasino, M,期刊:Molecular and Cellular Biology, 页码:2210-2226 , 文章类型: Article,,卷期:2011年31-11]
- Delta Np73 alpha, a dominant-negative inhibitor of p53 and p73, exhibits antiapoptotic and transforming activity in in vitro models and is often found to be upregulated in human cancers. The mechanisms involved in the re...
- The Dual Effect of Rac2 on Phospholipase D2 Regulation That Explains both the Onset and Termination of Chemotaxis
[作者:Peng, HJ; Henkels, KM; Mahankali, M; Marchal, C; Bubulya, P; Dinauer, MC; Gomez-Cambronero, J,期刊:Molecular and Cellular Biology, 页码:2227-2240 , 文章类型: Article,,卷期:2011年31-11]
- We document a biphasic effect of Rac2 on the activation and inhibition of PLD2. Cells overexpressing Rac2 and PLD2 simultaneously show a robust initial (<10 min) response toward a chemoattractant that is later (>30 min) ...
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