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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共12条记录   Pathological Signaling via Platelet-Derived Growth Factor Receptor alpha Involves Chronic Activation of Akt and Suppression of p53 [作者：Lei, HT; Velez, G; Kazlauskas, A,期刊：Molecular and Cellular Biology, 页码：1788-1799 , 文章类型： Article，,卷期：2011年31-9] In contrast to direct activation of platelet-derived growth factor (PDGF) receptor alpha (PDGFR alpha) via PDGF,indirect activation via growth factors outside the PDGF family failed to induce dimerization, internalizatio... KPNA6 (Importin alpha 7)-Mediated Nuclear Import of Keap1 Represses the Nrf2-Dependent Antioxidant Response [作者：Sun, Z; Wu, TD; Zhao, F; Lau, A; Birch, CM; Zhang, DD,期刊：Molecular and Cellular Biology, 页码：1800-1811 , 文章类型： Article，,卷期：2011年31-9] The transcription factor Nrf2 has emerged as a master regulator of cellular redox homeostasis. As an adaptive response to oxidative stress, Nrf2 activates the transcription of a battery of genes encoding antioxidants, de... RNA Helicase p68 (DDX5) Regulates tau Exon 10 Splicing by Modulating a Stem-Loop Structure at the 5 ' Splice Site [作者：Kar, A; Fushimi, K; Zhou, XH; Ray, P; Shi, C; Chen, XP; Liu, ZR; Chen, S; Wu, JY,期刊：Molecular and Cellular Biology, 页码：1812-1821 , 文章类型： Article，,卷期：2011年31-9] Regulation of tau exon 10 splicing plays an important role in tauopathy. One of the cis elements regulating tau alternative splicing is a stem-loop structure at the 5' splice site of tau exon 10. The RNA helicase(s) modu... Elongator Protein 3b Negatively Regulates Ribosomal DNA Transcription in African Trypanosomes [作者：Alsford, S; Horn, D,期刊：Molecular and Cellular Biology, 页码：1822-1832 , 文章类型： Article，,卷期：2011年31-9] Eukaryotic cells limit ribosomal DNA (rDNA) transcription by RNA polymerase I (RNAP-I) to maintain genome integrity. African trypanosomes present an excellent model for studies on RNAP-I regulation because they possess a... Functional Analysis of KAP1 Genomic Recruitment [作者：Iyengar, S; Ivanov, AV; Jin, VX; Rauscher, FJ; Farnham, PJ,期刊：Molecular and Cellular Biology, 页码：1833-1847 , 文章类型： Article，,卷期：2011年31-9] TRIM28 (KAP1) is upregulated in many cancers and has been implicated in both transcriptional activation and repression. Using chromatin immunoprecipitation and sequencing, we show that KAP1 binding sites fall into severa... Histone Variant H2A.Z and RNA Polymerase II Transcription Elongation [作者：Santisteban, MS; Hang, MD; Smith, MM,期刊：Molecular and Cellular Biology, 页码：1848-1860 , 文章类型： Article，,卷期：2011年31-9] Nucleosomes containing histone variant H2A.Z (Htz1) serve to poise quiescent genes for activation and transcriptional initiation. However, little is known about their role in transcription elongation. Here we show that d... Distinct Roles of DMAP1 in Mouse Development [作者：Mohan, KN; Ding, F; Chaillet, JR,期刊：Molecular and Cellular Biology, 页码：1861-1869 , 文章类型： Article，,卷期：2011年31-9] DMAP1 (DNMT1-associated protein 1) is a member of the TIP60-p400 complex that maintains embryonic stem (ES) cell pluripotency and a complex containing the somatic form of DNA methyltransferase 1 (DNMT1s). DMAP1 interacts... Cell-Type-Dependent Regulation of mTORC1 by REDD1 and the Tumor Suppressors TSC1/TSC2 and LKB1 in Response to Hypoxia [作者：Wolff, NC; Vega-Rubin-de-Celis, S; Xie, XJ; Castrillon, DH; Kabbani, W; Brugarolas, J,期刊：Molecular and Cellular Biology, 页码：1870-1884 , 文章类型： Article，,卷期：2011年31-9] mTORC1 is a critical regulator of cell growth that integrates multiple signals and is deregulated in cancer. We previously reported that mTORC1 regulation by hypoxia involves Redd1 and the Tsc1/Tsc2 complex. Here we show... Targeted Disruption of the Idol Gene Alters Cellular Regulation of the Low-Density Lipoprotein Receptor by Sterols and Liver X Receptor Agonists [作者：Scotti, E; Hong, C; Yoshinaga, Y; Tu, YP; Hu, Y; Zelcer, N; Boyadjian, R; de Jong, PJ; Young, SG; Fong, LG; Tontonoz, P,期刊：Molecular and Cellular Biology, 页码：1885-1893 , 文章类型： Article，,卷期：2011年31-9] Previously, we identified the E3 ubiquitin ligase Idol (inducible degrader of the low-density lipoprotein [LDL] receptor [LDLR]) as a posttranscriptional regulator of the LDLR pathway. Idol stimulates LDLR degradation th... An NK and T Cell Enhancer Lies 280 Kilobase Pairs 3 ' to the Gata3 Structural Gene [作者：Hosoya-Ohmura, S; Lin, YH; Herrmann, M; Kuroha, T; Rao, A; Moriguchi, T; Lim, KC; Hosoya, T; Engel, JD,期刊：Molecular and Cellular Biology, 页码：1894-1904 , 文章类型： Article，,卷期：2011年31-9] Transcription factor GATA-3 is vital for multiple stages of T cell and natural killer (NK) cell development, and yet the factors that directly regulate Gata3 transcription during hematopoiesis are only marginally defined... Calmodulin Antagonizes a Calcium-Activated SCF Ubiquitin E3 Ligase Subunit, FBXL2, To Regulate Surfactant Homeostasis [作者：Chen, BB; Coon, TA; Glasser, JR; Mallampalli, RK,期刊：Molecular and Cellular Biology, 页码：1905-1920 , 文章类型： Article，,卷期：2011年31-9] Calmodulin is a universal calcium-sensing protein that has pleiotropic effects. Here we show that calmodulin inhibits a new SCF (Skp1-Cullin-F-box) E3 ligase component, FBXL2. During Pseudomonas aeruginosa infection, SCF... Pathways for Holliday Junction Processing during Homologous Recombination in Saccharomyces cerevisiae [作者：Ashton, TM; Mankouri, HW; Heidenblut, A; McHugh, PJ; Hickson, ID,期刊：Molecular and Cellular Biology, 页码：1921-1933 , 文章类型： Article，,卷期：2011年31-9] The Saccharomyces cerevisiae Rmi1 protein is a component of the highly conserved Sgs1-Top3-Rmi1 complex. Deletion of SGS1, TOP3, or RMI1 is synthetically lethal when combined with the loss of the Mus81-Mms4 or Slx1-Slx4 ...