Current Pharmaceutical Design————————个性化文献订阅—

Prediction of MHC-Peptide Binding: A Systematic and Comprehensive Overview
[作者：Lafuente, EM; Reche, PA,期刊：Current Pharmaceutical Design, 页码：3209-3220 , 文章类型： Review，,卷期：2009年15-28]
T cell immune responses are driven by the recognition of peptide antigens (T cell epitopes) that are bound to major histocompatibility complex (MHC) molecules. T cell epitope immunogenicity is thus contingent on several ...

MHC and MHC-Like Molecules in the Design of Vaccines
[作者：Apostolopoulos, V,期刊：Current Pharmaceutical Design, 页码：3207-3208 , 文章类型： Editorial Material，,卷期：2009年15-28]

Models of Antigen Receptor Activation in the Design of Vaccines
[作者：Molnar, E; Dopfer, EP; Deswal, S; Schamel, WWA,期刊：Current Pharmaceutical Design, 页码：3237-3248 , 文章类型： Review，,卷期：2009年15-28]
Vaccination techniques have developed rapidly over the last several decades from the immunization with live attenuated pathogens to the use of peptide and DNA subunit vaccines, from the use of classical adjuvants to cell...

HLA-DR: Molecular Insights and Vaccine Design
[作者：Stern, LJ; Calvo-Calle, JM,期刊：Current Pharmaceutical Design, 页码：3249-3261 , 文章类型： Review，,卷期：2009年15-28]
Vaccines are one of the most cost effective methods to control infectious diseases and at the same time one of the most complex products of the pharmaceutical industry. In contrast to other drugs, vaccines are used mainl...

Characterization of MHC Ligands for Peptide Based Tumor Vaccination
[作者：Klug, F; Miller, M; Schmidt, HH; Stevanovic, S,期刊：Current Pharmaceutical Design, 页码：3221-3236 , 文章类型： Review，,卷期：2009年15-28]
Short peptides derived from cellular proteins may escape complete destruction during protein catabolism and finally serve as a showcase in the immune system. Exposed at the cell surface to scrutiny by T cells, MHC: pe...

Non-Canonical Peptides Bound to MHC
[作者：Day, SL; Ramsland, PA; Apostolopoulos, V,期刊：Current Pharmaceutical Design, 页码：3274-3282 , 文章类型： Review，,卷期：2009年15-28]
Central to the initiation of a T cell dependent immune response is the recognition of major histocompatibility complex (MHC) class I or class II molecules (in humans termed HLA and in mice termed H-2) bound to antigenic ...

''Self-Nonself" Peptides in the Design of Vaccines
[作者：Kanduc, D,期刊：Current Pharmaceutical Design, 页码：3283-3289 , 文章类型： Review，,卷期：2009年15-28]
What makes a peptide an epitope? This is a central question in immunology. The clear identification of precise molecular characteristics of epitopes would help define the basic mechanisms of self/non-self distinction and...

Use of MHC II Structural Features in the Design of Vaccines for Organ-Specific Autoimmune Diseases
[作者：Moustakas, AK; Papadopoulos, GK,期刊：Current Pharmaceutical Design, 页码：3262-3273 , 文章类型： Review，,卷期：2009年15-28]
The Major Histocompatibility Complex Class II locus is the primary genetic linkage to autoimmune diseases. Susceptibility to each such disease is linked to different alleles, with a few alleles showing also dominant prot...

The TCR/CD3 Complex: Opening the Gate to Successful Vaccination
[作者：Portoles, P; Rojo, JM,期刊：Current Pharmaceutical Design, 页码：3290-3300 , 文章类型： Review，,卷期：2009年15-28]
The success of vaccination is directly or indirectly based on the specificity of antigen recognition by T lymphocytes, their efficient activation and expansion, and the generation of vaccine-specific effector and memory ...

Presentation of Lipid Antigens by CD1 Glycoproteins
[作者：Schiefner, A; Wilson, IA,期刊：Current Pharmaceutical Design, 页码：3311-3317 , 文章类型： Review，,卷期：2009年15-28]
CD1 molecules are a family of non-polymorphic, class I antigen-presenting glycoproteins, which bind and present amphiphilic lipid antigens for recognition to T cells. Two groups of CD1 molecules are involved in presentat...

HLA-G Molecule
[作者：Kamishikiryo, J; Maenaka, K,期刊：Current Pharmaceutical Design, 页码：3318-3324 , 文章类型： Review，,卷期：2009年15-28]
Human leukocyte antigen-G (HLA-G) is a non-classical HLA class I molecule, which was first discovered in 1987 by Geraghty and colleagues [1]. While classical HLA class I molecules are expressed on all nucleated cells, th...

NK Cell Receptors and Their Interactions with MHC
[作者：Biassoni, R; Ugolotti, E; De Maria, A,期刊：Current Pharmaceutical Design, 页码：3301-3310 , 文章类型： Review，,卷期：2009年15-28]
MHC-specific Natural Killer inhibitory receptors display a conserved and fundamental function in the regulation of NK-mediated cytolysis. Their importance is substantiated by the fact that during speciation different mol...

HPLC and MS Analysis for the Identification and Characterisation of Peptides Presented in the Context of the Non-Classical Human Leukocytes Antigen (HLA) Class I Molecule HLA-E
[作者：Millo, E; Damonte, G,期刊：Current Pharmaceutical Design, 页码：3325-3335 , 文章类型： Review，,卷期：2009年15-28]
In addition to a variety of other techniques used in T-cell epitope identification, mass spectrometery coupled to liquid chromatography have now become an important and sensitive tool in separation, detection, and sequen...

HLA-E and HLA-E-Bound Peptides: Recognition by Subsets of NK and T Cells
[作者：Pietra, G; Romagnani, C; Moretta, L; Mingari, MC,期刊：Current Pharmaceutical Design, 页码：3336-3344 , 文章类型： Review，,卷期：2009年15-28]
In humans, major histocompatibility complex (MHC) class I molecules comprise the classical (class Ia) human leukocyte antigens (HLA)-A, -B, and -C, and the non-classical (class Ib) HLA-E, -F, -G and -H (HFE) molecules. T...