- Molecular dynamics simulations of the amyloid-beta binding alcohol dehydrogenase (ABAD) enzyme.
[作者:Marques, Alexandra T.;Fernandes, Pedro A.;Ramos, Maria Joao;,期刊:Bioorganic & Medicinal Chemistry, 页码:9511-9518 , 文章类型: 研究论文,,卷期:2008年16-21]
- In this work, we present 10 ns mol. dynamics (MD) simulations of the homotetramer of Ab-binding alc. dehydrogenase (ABAD, also known as HSD10), as well as simulations of the dimer and monomer structural units that assemb...
- Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp.
[作者:Brito, Adriana S.;Arimateia, Dayse S.;Souza, Lucilla R.;Lima, Marcelo A.;Santos, Vanessa O.;Medeiros, Valquiria P.;Ferreira, Paula A.;Silva, Rodrigo A.;Ferreira, Carmen V.;Justo, Giselle Z.;Leite, Edda L.;Andrade, Giulianna P. V.;Oliveira, Fernanda W.;Nad,期刊:Bioorganic & Medicinal Chemistry, 页码:9588-9595 , 文章类型: 研究论文,,卷期:2008年16-21]
- The antiinflammatory properties of a heparin-like compd. from the shrimp Litopenaeus vannamei are related. Besides reducing significantly (p < 0.001) the influx of inflammatory cells to injury site in a model of acute i...
- Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana.
[作者:Arai, Midori A.;Tateno, Chikashi;Hosoya, Takahiro;Koyano, Takashi;Kowithayakorn, Thaworn;Ishibashi, Masami;,期刊:Bioorganic & Medicinal Chemistry, 页码:9420-9424 , 文章类型: 研究论文,,卷期:2008年16-21]
- The aberrant hedgehog (Hh)/GLI signaling pathway causes the formation and progression of a variety of tumors. By screening tropical plant exts. by using our screening system, Zizyphus cambodiana was found to include Hh/...
- Influence of 6- or 8-substitution on the antiviral activity of 3-arylalkylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (CMV) and varicella-zoster virus (VZV): Part II.
[作者:Veron, Jean-Baptiste;Allouchi, Hassan;Enguehard-Gueiffier, Cecile;Snoeck, Robert;Andrei, Graciela;De Clercq, Erik;Gueiffier, Alain;,期刊:Bioorganic & Medicinal Chemistry, 页码:9536-9545 , 文章类型: 研究论文,,卷期:2008年16-21]
- The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and diversely substituted on the 6 or 8 position, and their antiviral activities are reported. From the synthesized comp...
- Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: Structure-activity relationship and mechanism of action.
[作者:Van Neck, Tine;Pannecouque, Christophe;Vanstreels, Els;Stevens, Miguel;Dehaen, Wim;Daelemans, Dirk;,期刊:Bioorganic & Medicinal Chemistry, 页码:9487-9497 , 文章类型: 研究论文,,卷期:2008年16-21]
- CRM1-mediated nucleocytoplasmic transport plays an important role in many cellular processes and diseases. To investigate the structural basis required for the inhibition of the CRM1-mediated nuclear export we have synt...
- Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: Synthesis and CRAC channel inhibitory activity of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides.
[作者:Yonetoku, Yasuhiro;Kubota, Hirokazu;Miyazaki, Yoji;Okamoto, Yoshinori;Funatsu, Masashi;Yoshimura-Ishikawa, Noriko;Ishikawa, Jun;Yoshino, Taiji;Takeuchi, Makoto;Ohta, Mitsuaki;,期刊:Bioorganic & Medicinal Chemistry, 页码:9457-9466 , 文章类型: 研究论文,,卷期:2008年16-21]
- From a series of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides derived from 4-methyl-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5- carboxanilide, one inhibited thapsigargin-induced Ca2+ influx in ...
- Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D1 receptor activities.
[作者:Zhang, Jing;Chen, Xuetao;Yu, Leiping;Zhen, Xuechu;Zhang, Ao;,期刊:Bioorganic & Medicinal Chemistry, 页码:9425-9431 , 文章类型: 研究论文,,卷期:2008年16-21]
- 17a,b were prepd. All these compds. showed binding potencies compatible to or much higher than that of the prototypic (?-SKF-38393 ((?-1) and (?-SKF-83959 (3) for the D1 receptor. Among analogs of (?-SKF-38393, compds....
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