- The phosphatidylinositol transfer protein RdgB beta binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein)
[作者:Garner, K; Li, M; Ugwuanya, N; Cockcroft, S,期刊:Biochemical Journal, 页码:97-111 , 文章类型: Article,,卷期:2011年439-1]
- PITPs [PI (phosphatidylinositol) transfer proteins] bind and transfer PI between intracellular membranes and participate in many cellular processes including signalling, lipid metabolism and membrane traffic. The largely...
- Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L
[作者:Savalas, LRT; Gasnier, B; Damme, M; Lubke, T; Wrocklage, C; Debacker, C; Jezegou, A; Reinheckel, T; Hasilik, A; Saftig, P; Schroder, B,期刊:Biochemical Journal, 页码:113-128 , 文章类型: Article,,卷期:2011年439-1]
- DIRC2 (Disrupted in renal carcinoma 2) has been initially identified as a breakpoint-spanning gene in a chromosomal translocation putatively associated with the development of renal cancer. The DIRC2 protein belongs to t...
- SLC41A1 Mg(2+) transport is regulated via Mg(2+)-dependent endosomal recycling through its N-terminal cytoplasmic domain
[作者:Mandt, T; Song, YM; Scharenberg, AM; Sahni, J,期刊:Biochemical Journal, 页码:129-139 , 文章类型: Article,,卷期:2011年439-1]
- SLC41A1 (solute carrier family 41, member A1) is a recently described vertebrate member of the MgtE family of Mg(2+) transporters. Although MgtE transporters are found in both prokaryotic and eukaryotic organisms, and ar...
- Modulation of doxorubicin resistance by the glucose-6-phosphate dehydrogenase activity
[作者:Polimeni, M; Voena, C; Kopecka, J; Riganti, C; Pescarmona, G; Bosia, A; Ghigo, D,期刊:Biochemical Journal, 页码:141-149 , 文章类型: Article,,卷期:2011年439-1]
- How anti-neoplastic agents induce MDR (multidrug resistance) in cancer cells and the role of GSH (glutathione) in the activation of pumps such as the MRPs (MDR-associated proteins) are still open questions. In the presen...
- Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling
[作者:Wu, CL; Buszard, B; Teng, CH; Chen, WL; Warr, CG; Tiganis, T; Meng, TC,期刊:Biochemical Journal, 页码:151-159 , 文章类型: Article,,卷期:2011年439-1]
- PTP1B (protein tyrosine phosphatase 1B) is a negative regulator of IR (insulin receptor) activation and glucose homoeostasis, but the precise molecular mechanisms governing PTP1B substrate selectivity and the regulation ...
- CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes
[作者:Ma, X; Zhang, HY; Yuan, L; Jing, H; Thacker, P; Li, DL,期刊:Biochemical Journal, 页码:27-38 , 文章类型: Article,,卷期:2011年439-1]
- The factors that influence preadipocyte determination remain poorly understood. In the present paper, we report that CREBL2 [CREB (cAMP-response-element-binding protein)-like 2], a novel bZIP_1 protein, is up-regulated d...
- Autotaxin induces lung epithelial cell migration through lysoPLD activity-dependent and -independent pathways
[作者:Zhao, J; He, DH; Berdyshev, E; Zhong, MT; Salgia, R; Morris, AJ; Smyth, SS; Natarajan, V; Zhao, YT,期刊:Biochemical Journal, 页码:45-55 , 文章类型: Article,,卷期:2011年439-1]
- Lung cell migration is a crucial step for re-epithelialization that in turn is essential for remodelling and repair after lung injury. In the present paper we hypothesize that secreted ATX (autotaxin), which exhibits lys...
- A beta 42 oligomers, but not fibrils, simultaneously bind to and cause damage to ganglioside-containing lipid membranes
[作者:Williams, TL; Johnson, BRG; Urbanc, B; Jenkins, ATA; Connell, SDA; Serpell, LC,期刊:Biochemical Journal, 页码:67-77 , 文章类型: Article,,卷期:2011年439-1]
- A beta (amyloid-beta peptide) assembles to form amyloid fibres that accumulate in senile plaques associated with AD (Alzheimer's disease). The major constituent, a 42-residue A beta, has the propensity to assemble and fo...
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