个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共14条记录   Horizon scanning for novel therapeutics for the treatment of prostate cancer [作者：Bianchini, D; Zivi, A; Sandhu, S; de Bono, JS,期刊：Expert opinion on investigational drugs, 页码：1487-1502 , 文章类型： Review，,卷期：2010年19-12] Importance of the field: Treatment options for patients with advanced prostate cancer (PCa) remain limited. Improved understanding of the underlying molecular drivers of prostate cancer pathogenesis, progression and resi... Perspective: does ranolazine have potential for the treatment of atrial fibrillation? [作者：Hancox, JC; Doggrell, SA,期刊：Expert opinion on investigational drugs, 页码：1465-1474 , 文章类型： Article，,卷期：2010年19-12] Atrial fibrillation is the most common arrhythmia seen in clinical practice, and novel pharmacological approaches for treatment are sought. Ranolazine (Ranexa; N-(2,6-dimethylphenyl)-2-[4-(2-hydroxy-3-[2-methoxyphenoxy]p... Clinical pharmacology study of the corticosteroid nasal spray dexamethasone cipecilate (NS-126): examination of the durability of efficacy in the nasal induction test [作者：Gotoh, M; Okubo, K; Okuda, M; Hamada, C,期刊：Expert opinion on investigational drugs, 页码：1475-1486 , 文章类型： Article，,卷期：2010年19-12] Background: Dexamethasone cipecilate is a corticosteroid nasal spray whose local efficacy durability has been improved by introduction of a liposoluble functional group to its chemical structure. This study was conducted... New drugs in advanced non-small-cell lung cancer: searching for the correct clinical development [作者：Di Maio, M; Morabito, A; Piccirillo, MC; Daniele, G; Giordano, P; Costanzo, R; Riccardi, MG; Rocco, G; Normanno, N; Perrone, F,期刊：Expert opinion on investigational drugs, 页码：1503-1514 , 文章类型： Review，,卷期：2010年19-12] Importance of the field: Non-small-cell lung cancer (NSCLC) is one of the most active fields of research in oncology, with many drugs under clinical development. Most of these drugs offer novel mechanisms of action compa... Biological versatility of crotamine - a cationic peptide from the venom of a South American rattlesnake [作者：Kerkis, I; Silva, FD; Pereira, A; Kerkis, A; Radis-Baptista, G,期刊：Expert opinion on investigational drugs, 页码：1515-1525 , 文章类型： Review，,卷期：2010年19-12] Importance of the field: Molecules isolated from animals, insects, plants or microorganisms can provide prototypes for design of biopharmaceutical products. Some venom toxins and their derivatives are used in medicine, w... Therapeutic potential of new second generation antipsychotics for major depressive disorder [作者：McElroy, SL; Guerdjikova, A; Mori, N; Keck, PE,期刊：Expert opinion on investigational drugs, 页码：1527-1544 , 文章类型： Review，,卷期：2010年19-12] Importance of the field: Although a range of antidepressant medications are available, a substantial number of patients either do not respond adequately to these or are unable to tolerate their adverse effects. A treatme... Na+/H+ exchanger-1: a link with atherogenesis? [作者：Sarigianni, M; Tsapas, A; Mikhailidis, DP; Kaloyianni, M; Koliakos, G; Fliegel, L; Paletas, K,期刊：Expert opinion on investigational drugs, 页码：1545-1556 , 文章类型： Review，,卷期：2010年19-12] Importance of the field: The sodium/hydrogen exchanger-1 (NHE-1/SLC9A1) is a ubiquitous plasma membrane protein whose main role is maintenance of intracellular pH and volume. NHE-1 plays a role in atherogenesis; however,... Inhibiting PAR-1 in the prevention and treatment of atherothrombotic events [作者：Tomasello, SD; Angiolillo, DJ; Goto, S,期刊：Expert opinion on investigational drugs, 页码：1557-1567 , 文章类型： Review，,卷期：2010年19-12] Importance of the field: Aspirin, an irreversible inhibitor of thromboxane A(2) production, in combination with clopidogrel, an inhibitor of PY12 ADP platelet receptors, represents the current standard-of-care of antipla... Farnesyltransferase inhibitors: where are we now? [作者：Tsimberidou, AM; Chandhasin, C; Kurzrock, R,期刊：Expert opinion on investigational drugs, 页码：1569-1580 , 文章类型： Review，,卷期：2010年19-12] Importance of the field: Farnesyltransferase inhibitors (FTIs) target multiple pathways implicated in the pathogenesis of solid and hematologic malignancies. Areas covered in this review: Novel preclinical and clinical d... Dapagliflozin: more than just another oral glucose-lowering agent? [作者：Katsiki, N; Papanas, N; Mikhailidis, DP,期刊：Expert opinion on investigational drugs, 页码：1581-1589 , 文章类型： Article，,卷期：2010年19-12] Importance of the field: With current hypoglycemic therapies, only half of type 2 diabetes mellitus (T2DM) patients achieve optimal glycemic control and even fewer maintain it. Therefore, there is an unmet need for novel... Afamelanotide, an agonistic analog of alpha-melanocyte-stimulating hormone, in dermal phototoxicity of erythropoietic protoporphyria [作者：Minder, EI,期刊：Expert opinion on investigational drugs, 页码：1591-1602 , 文章类型： Article，,卷期：2010年19-12] Importance of the field: Afamelanotide, an alpha-melanocyte stimulating hormone (MSH) agonistic analog is a first-in-class therapeutic. Its application to protoporphyria (PP), a disease associated with absolute sunlight-... Dimethyl fumarate for multiple sclerosis [作者：Papadopoulou, A; D'Souza, M; Kappos, L; Yaldizli, O,期刊：Expert opinion on investigational drugs, 页码：1603-1612 , 文章类型： Article，,卷期：2010年19-12] Importance of the field: One of the disadvantages of currently available disease-modifying drugs (DMDs) for multiple sclerosis (MS) is their parenteral administration. Moreover, efficacy is only partial. Most patients tr... Bazedoxifene when paired with conjugated estrogens is a new paradigm for treatment of postmenopausal women [作者：Pinkerton, JV; Stovall, DW,期刊：Expert opinion on investigational drugs, 页码：1613-1621 , 文章类型： Article，,卷期：2010年19-12] Importance of the field: The concept of the tissue selective estrogen complex (TSEC) combining a selective estrogen receptor modulator (SERM) with one or more estrogens, aims to provide comparable efficacy to combination... Delayed release phosphatidylcholine as new therapeutic drug for ulcerative colitis - a review of three clinical trials [作者：Stremmel, W; Hanemann, A; Braun, A; Stoffels, S; Karner, M; Fazeli, S; Ehehalt, R,期刊：Expert opinion on investigational drugs, 页码：1623-1630 , 文章类型： Article，,卷期：2010年19-12] Importance of the field: As the pathogenesis of ulcerative colitis (UC) is unknown, a causative therapy is lacking. Therefore, some UC patients suffer from disease activity despite symptomatic anti-inflammatory treatment...