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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共13条记录   Neuroimaging to assess safety and efficacy of AD therapies [作者：Hill, D,期刊：Expert opinion on investigational drugs, 页码：23-26 , 文章类型： Article，,卷期：2010年19-1] During the last two decades, neuroimaging methods have become widely used to study the natural history of Alzheimer's disease and also as a means of assessing safety and efficacy of novel treatments. Widely used safety a... Polo-like kinase inhibitors: an emerging opportunity for cancer therapeutics [作者：Chopra, P; Sethi, G; Dastidar, SG; Ray, A,期刊：Expert opinion on investigational drugs, 页码：27-43 , 文章类型： Review，,卷期：2010年19-1] Importance of the field. The Polo-like kinase (Plk) family has emerged as an important regulator in cell cycle progression. Plks belong to a family of serine/threonine kinases and exist in four isoforms Plk1- 4. However,... Discontinued drugs in 2008: anti-infectives [作者：Ryder, NS,期刊：Expert opinion on investigational drugs, 页码：1-21 , 文章类型： Article，,卷期：2010年19-1] Of the many drugs dropped from development in 2008, 27 were under development for therapy or prophylaxis of infectious diseases. The majority of these were for diseases of viral etiology (15 agents), while nine were anti... Investigational drugs for hepatitis C [作者：Flisiak, R; Parfieniuk, A,期刊：Expert opinion on investigational drugs, 页码：63-75 , 文章类型： Review，,卷期：2010年19-1] Importance of the field. Hepatitis C virus (HCV) infection affects 180 million people worldwide. Standard anti-HCV therapy combines effect of pegylated IFN-alpha on immune response and antiviral activity of ribavirin. Su... Targeting the transforming growth factor-beta signaling pathway in human cancer [作者：Nagaraj, NS; Datta, PK,期刊：Expert opinion on investigational drugs, 页码：77-91 , 文章类型： Review，,卷期：2010年19-1] The transforming growth factor-beta (TGF-beta) signaling pathway plays a pivotal role in diverse cellular processes. TGF-beta switches its role from a tumor suppressor in normal or dysplastic cells to a tumor promoter in... Targeting voltage-gated sodium channels for pain therapy [作者：Clare, JJ,期刊：Expert opinion on investigational drugs, 页码：45-62 , 文章类型： Review，,卷期：2010年19-1] Drugs inhibiting voltage-gated sodium channels have long been used as analgesics, beginning with the use of local anaesthetics for sensory blockade and then with the discovery that Nav-blocking anticonvulsants also have ... Investigational drugs for allergic rhinitis [作者：Passalacqua, G; Compalati, E; Canonica, GW,期刊：Expert opinion on investigational drugs, 页码：93-103 , 文章类型： Review，,卷期：2010年19-1] Allergic rhinitis (AR) is a high-prevalence disease, triggered by an IgE-mediated reaction, and sustained by a complex inflammatory network of cells, mediators, and cytokines. When the exposure to allergens persists, the... Novel TNF antagonists for the treatment of rheumatoid arthritis [作者：Statkute, L; Ruderman, EM,期刊：Expert opinion on investigational drugs, 页码：105-115 , 文章类型： Review，,卷期：2010年19-1] Importance of the field. TNF antagonists have become an integral part of the standard of care for patients with rheumatoid arthritis (RA). Two additional TNF antagonists have recently been approved in the US for this ind... Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes [作者：Deacon, CF; Holst, JJ,期刊：Expert opinion on investigational drugs, 页码：133-140 , 文章类型： Article，,卷期：2010年19-1] Importance of the field. Type 2 diabetes is a progressive disease for which current treatments are often unsatisfactory with respect to achieving therapeutic goals and unwanted side effects. Areas covered. Preclinical an... Targeting cancer with phosphodiesterase inhibitors [作者：Savai, R; Pullamsetti, SS; Banat, GA; Weissmann, N; Ghofrani, HA; Grimminger, F; Schermuly, RT,期刊：Expert opinion on investigational drugs, 页码：117-131 , 文章类型： Review，,卷期：2010年19-1] Importance of the field. For many cancers, there has been a shift from management with traditional, nonspecific cytotoxic chemotherapies to treatment with molecule-specific targeted therapies that are used either alone o... Darapladib [作者：Bui, QT; Wilensky, RL,期刊：Expert opinion on investigational drugs, 页码：161-168 , 文章类型： Article，,卷期：2010年19-1] Importance of the field. Atherosclerosis is an inflammatory-immune mediated disease process. Plaque rupture is responsible for the clinical events of ischemic death, myocardial infarction, acute coronary syndromes and is... Milatuzumab - a promising new immunotherapeutic agent [作者：Berkova, Z; Tao, RH; Samaniego, F,期刊：Expert opinion on investigational drugs, 页码：141-149 , 文章类型： Article，,卷期：2010年19-1] Milatuzumab is a new immunotherapeutic agent targeting CD74, a membrane protein preferentially expressed in hematopoietic cancers and some solid tumors. Broad expression and fast internalization makes CD74 an ideal targe... The efficacy and safety of telaprevir - a new protease inhibitor against hepatitis C virus [作者：Gentile, I; Carleo, MA; Borgia, F; Castaldo, G; Borgia, G,期刊：Expert opinion on investigational drugs, 页码：151-159 , 文章类型： Article，,卷期：2010年19-1] Importance of the field. Hepatitis C virus (HCV) is the main agent of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma in the western world. It affects more than 170 million people worldwide. HCV treatment...