- Targeting the angiopoietin (Ang)/Tie-2 pathway in the crosstalk between acute myeloid leukaemia and endothelial cells: studies of Tie-2 blocking antibodies, exogenous Ang-2 and inhibition of constitutive agonistic Ang-1 release
[作者:Reikvam, H; Hatfield, KJ; Lassalle, P; Kittang, AO; Ersvaer, E; Bruserud, O,期刊:Expert opinion on investigational drugs, 页码:169-183 , 文章类型: Article,,卷期:2010年19-2]
- Background. The Tie-2 receptor can bind its agonistic ligand Angiopoietin-1 (Ang-1) and the potential antagonist Ang-2. Tie-2 can be expressed both by primary human acute myeloid leukaemia (AML) cells and endothelial cel...
- Targeting silibinin in the antiproliferative pathway
[作者:Li, L; Zeng, J; Gao, Y; He, DL,期刊:Expert opinion on investigational drugs, 页码:243-255 , 文章类型: Review,,卷期:2010年19-2]
- Importance of the field. Due to the failure and severe toxicity of cancer chemotherapy, silibinin, a natural flavonoid from the seeds of milk thistle, has recently received more attention for its potential anticancer and...
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