- Cross-talk between Insulin and Wnt Signaling in Preadipocytes ROLE OF WNT CO-RECEPTOR LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-5 (LRP5)
[作者:Palsgaard, J; Emanuelli, B; Winnay, JN; Sumara, G; Karsenty, G; Kahn, CR,期刊:Journal of Biological Chemistry, 页码:12016-12026 , 文章类型: Article,,卷期:2012年287-15]
- Disturbed Wnt signaling has been implicated in numerous diseases, including type 2 diabetes and the metabolic syndrome. In the present study, we have investigated cross-talk between insulin and Wnt signaling pathways usi...
- Familial Focal Segmental Glomerulosclerosis (FSGS)-linked alpha-Actinin 4 (ACTN4) Protein Mutants Lose Ability to Activate Transcription by Nuclear Hormone Receptors
[作者:Khurana, S; Chakraborty, S; Lam, M; Liu, Y; Su, YT; Zhao, X; Saleem, MA; Mathieson, PW; Bruggeman, LA; Kao, HY,期刊:Journal of Biological Chemistry, 页码:12027-12035 , 文章类型: Article,,卷期:2012年287-15]
- Mutations in alpha-actinin 4 (ACTN4) are linked to familial forms of focal segmental glomerulosclerosis (FSGS), a kidney disease characterized by proteinuria due to podocyte injury. The mechanisms underlying ACTN4 mutant...
- Monoubiquitinated Histone H2A Destabilizes Photolesion-containing Nucleosomes with Concomitant Release of UV-damaged DNA-binding Protein E3 Ligase
[作者:Lan, L; Nakajima, S; Kapetanaki, MG; Hsieh, CL; Fagerburg, M; Thickman, K; Rodriguez-Collazo, P; Leuba, SH; Levine, AS; Rapic-Otrin, V,期刊:Journal of Biological Chemistry, 页码:12036-12049 , 文章类型: Article,,卷期:2012年287-15]
- How the nucleotide excision repair (NER) machinery gains access to damaged chromatinized DNA templates and how the chromatin structure is modified to promote efficient repair of the non-transcribed genome remain poorly u...
- TRIM67 Protein Negatively Regulates Ras Activity through Degradation of 80K-H and Induces Neuritogenesis
[作者:Yaguchi, H; Okumura, F; Takahashi, H; Kano, T; Kameda, H; Uchigashima, M; Tanaka, S; Watanabe, M; Sasaki, H; Hatakeyama, S,期刊:Journal of Biological Chemistry, 页码:12050-12059 , 文章类型: Article,,卷期:2012年287-15]
- Tripartite motif (TRIM)-containing proteins, which are defined by the presence of a common domain structure composed of a RING finger, one or two B-box motifs and a coiled-coil motif, are involved in many biological proc...
- Eukaryotic Class II Cyclobutane Pyrimidine Dimer Photolyase Structure Reveals Basis for Improved Ultraviolet Tolerance in Plants
[作者:Hitomi, K; Arvai, AS; Yamamoto, J; Hitomi, C; Teranishi, M; Hirouchi, T; Yamamoto, K; Iwai, S; Tainer, JA; Hidema, J; Getzoff, ED,期刊:Journal of Biological Chemistry, 页码:12060-12069 , 文章类型: Article,,卷期:2012年287-15]
- Ozone depletion increases terrestrial solar ultraviolet B (UV-B; 280-315 nm) radiation, intensifying the risks plants face from DNA damage, especially covalent cyclobutane pyrimidine dimers (CPD). Without efficient repai...
- Allosteric Modulator ORG27569 Induces CB1 Cannabinoid Receptor High Affinity Agonist Binding State, Receptor Internalization, and G(i) Protein-independent ERK1/2 Kinase Activation
[作者:Ahn, KH; Mahmoud, MM; Kendall, DA,期刊:Journal of Biological Chemistry, 页码:12070-12082 , 文章类型: Article,,卷期:2012年287-15]
- The cannabinoid receptor 1 (CB1), a member of the class A G protein-coupled receptor family, is expressed in brain tissue where agonist stimulation primarily activates the pertussis toxin-sensitive inhibitory G protein (...
- GABRB3 Mutation, G32R, Associated with Childhood Absence Epilepsy Alters alpha 1 beta 3 gamma 2L gamma-Aminobutyric Acid Type A (GABA(A)) Receptor Expression and Channel Gating
[作者:Gurba, KN; Hernandez, CC; Hu, NN; Macdonald, RL,期刊:Journal of Biological Chemistry, 页码:12083-12097 , 文章类型: Article,,卷期:2012年287-15]
- A GABA(A) receptor beta 3 subunit mutation, G32R, has been associated with childhood absence epilepsy. We evaluated the possibility that this mutation, which is located adjacent to the most N-terminal of three beta 3 sub...
- Regulated Clearance of Histone Deacetylase 3 Protects Independent Formation of Nuclear Receptor Corepressor Complexes
[作者:Guo, C; Gow, CH; Li, YL; Gardner, A; Khan, S; Zhang, JS,期刊:Journal of Biological Chemistry, 页码:12111-12120 , 文章类型: Article,,卷期:2012年287-15]
- An important step in transcriptional regulation by corepressors N-CoR and SMRT is the formation of a stable and active histone deacetylase 3 (HDAC3)-containing complex. Although N-CoR and SMRT are thought to bind HDAC3 c...
- Bifunctional cis-Abienol Synthase from Abies balsamea Discovered by Transcriptome Sequencing and Its Implications for Diterpenoid Fragrance Production
[作者:Zerbe, P; Chiang, A; Yuen, M; Hamberger, B; Hamberger, B; Draper, JA; Britton, R; Bohlmann, J,期刊:Journal of Biological Chemistry, 页码:12121-12131 , 文章类型: Article,,卷期:2012年287-15]
- The labdanoid diterpene alcohol cis-abienol is a major component of the aromatic oleoresin of balsam fir (Abies balsamea) and serves as a valuable bioproduct material for the fragrance industry. Using high-throughput 454...
- Inhibition of Chemokine (CXC Motif) Ligand 12/Chemokine (CXC Motif) Receptor 4 Axis (CXCL12/CXCR4)-mediated Cell Migration by Targeting Mammalian Target of Rapamycin (mTOR) Pathway in Human Gastric Carcinoma Cells
[作者:Chen, G; Chen, SM; Wang, X; Ding, XF; Ding, J; Meng, LH,期刊:Journal of Biological Chemistry, 页码:12132-12141 , 文章类型: Article,,卷期:2012年287-15]
- CXCL12/CXCR4 plays an important role in metastasis of gastric carcinoma. Rapamycin has been reported to inhibit migration of gastric cancer cells. However, the role of mTOR pathway in CXCL12/CXCR4-mediated cell migration...
- Cytosolic Ni(II) Sensor in Cyanobacterium NICKEL DETECTION FOLLOWS NICKEL AFFINITY ACROSS FOUR FAMILIES OF METAL SENSORS
[作者:Foster, AW; Patterson, CJ; Pernil, R; Hess, CR; Robinson, NJ,期刊:Journal of Biological Chemistry, 页码:12142-12151 , 文章类型: Article,,卷期:2012年287-15]
- Efflux of surplus Ni(II) across the outer and inner membranes of Synechocystis PCC 6803 is mediated by the Nrs system under the control of a sensor of periplasmic Ni(II), NrsS. Here, we show that the product of ORF sll01...
- Modification of cysteine 179 of I kappa B alpha kinase by nimbolide leads to down-regulation of NF-kappa B-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents (vol 285, pg 35406, 2010)
[作者:Gupta, SC; Prasad, S; Reuter, S; Kannappan, R; Yadav, VR; Ravindran, J; Hema, PS; Chaturvedi, MM; Nair, M; Aggarwal, BB,期刊:Journal of Biological Chemistry, 页码:12152-12152 , 文章类型: Correction,,卷期:2012年287-15]
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- Cell entry of avian reovirus follows a caveolin-1-mediated and dynamin-2-dependent endocytic pathway that requires activation of p38 mitogen-activated protein kinase (MAPK) and Src signaling pathways as well as microtubules and small GTPase Rab5 protein (vol 286, pg 30780, 2011)
[作者:Huang, WR; Wang, YC; Chi, PI; Wang, L; Wang, CY; Lin, CH; Liu, HJ,期刊:Journal of Biological Chemistry, 页码:12153-12153 , 文章类型: Correction,,卷期:2012年287-15]
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- TGF-beta-activated Kinase 1 (TAK1) and Apoptosis Signal-regulating Kinase 1 (ASK1) Interact with the Promyogenic Receptor Cdo to Promote Myogenic Differentiation via Activation of p38MAPK Pathway
[作者:Tran, P; Ho, SM; Kim, BG; Vuong, TA; Leem, YE; Bae, GU; Kang, JS,期刊:Journal of Biological Chemistry, 页码:11602-11615 , 文章类型: Article,,卷期:2012年287-15]
- p38MAPK plays an essential role in the transition of myoblasts to differentiated myotubes through the activation of MyoD family transcription factors. A promyogenic cell surface molecule, Cdo, promotes myogenic different...
- Role of Osteoglycin in the Linkage between Muscle and Bone
[作者:Tanaka, K; Matsumoto, E; Higashimaki, Y; Katagiri, T; Sugimoto, T; Seino, S; Kaji, H,期刊:Journal of Biological Chemistry, 页码:11616-11628 , 文章类型: Article,,卷期:2012年287-15]
- The interaction between muscle tissues and bone metabolism is incompletely understood. We hypothesized that there might be some humoral factors that are produced in muscle tissues and exhibit bone anabolic activity. We, ...
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