- Enzymatic (13)C Labeling and Multidimensional NMR Analysis of Miltiradiene Synthesized by Bifunctional Diterpene Cyclase in Selaginella moellendorffii
[作者:Sugai, Y; Ueno, Y; Hayashi, K; Oogami, S; Toyomasu, T; Matsumoto, S; Natsume, M; Nozaki, H; Kawaide, H,期刊:Journal of Biological Chemistry, 页码:42840-42847 , 文章类型: Article,,卷期:2011年286-50]
- Background: A model lycophyte, Selaginella moellendorffii, has a unique bifunctional terpene cyclase gene. Results: The bifunctional cyclase synthesized miltiradiene from geranylgeranyl diphosphate via (+)-copalyl diphos...
- Interplay between Vascular Endothelial Growth Factor (VEGF) and Nuclear Factor Erythroid 2-related Factor-2 (Nrf2) IMPLICATIONS FOR PREECLAMPSIA
[作者:Kweider, N; Fragoulis, A; Rosen, C; Pecks, U; Rath, W; Pufe, T; Wruck, CJ,期刊:Journal of Biological Chemistry, 页码:42863-42872 , 文章类型: Article,,卷期:2011年286-50]
- Background: Several studies have suggested that decreasing VEGF levels might result in placental oxidative stress in preeclampsia. Results: VEGF activates Nrf2 in an ERK1/2-dependent manner, protecting against oxidative ...
- The Nucleotide-binding State of Microtubules Modulates Kinesin Processivity and the Ability of Tau to Inhibit Kinesin-mediated Transport
[作者:McVicker, DP; Chrin, LR; Berger, CL,期刊:Journal of Biological Chemistry, 页码:42873-42880 , 文章类型: Article,,卷期:2011年286-50]
- Background: Tau inhibits kinesin on GDP-microtubules in vitro, but the physiological significance in neurons is unclear. Results: On GTP-microtubules, Tau loses its inhibitory effect, and kinesin becomes less processive....
- Stabilization of the alpha 2 Isoform of Na,K-ATPase by Mutations in a Phospholipid Binding Pocket
[作者:Kapri-Pardes, E; Katz, A; Haviv, H; Mahmmoud, Y; Ilan, M; Khalfin-Penigel, I; Carmeli, S; Yarden, O; Karlish, SJD,期刊:Journal of Biological Chemistry, 页码:42888-42899 , 文章类型: Article,,卷期:2011年286-50]
- Background: The alpha 2 isoform of Na, K-ATPase is unstable compared with alpha 1 and alpha 3. Results: Mutations in TM8-10 strongly stabilize alpha 2. A novel phospholipid antagonist selectively inactivates alpha 2, and...
- Protein Phosphatase 5 Mediates Lipid Metabolism through Reciprocal Control of Glucocorticoid Receptor and Peroxisome Proliferator-activated Receptor-gamma (PPAR gamma)
[作者:Hinds, TD; Stechschulte, LA; Cash, HA; Whisler, D; Banerjee, A; Yong, WD; Khuder, SS; Kaw, MK; Shou, WN; Najjar, SM; Sanchez, ER,期刊:Journal of Biological Chemistry, 页码:42911-42922 , 文章类型: Article,,卷期:2011年286-50]
- Background: The glucocorticoid (GR) and peroxisome proliferator-activated (PPAR gamma) receptors are antagonists of lipid metabolism. Results: Protein phosphatase 5 (PP5) dephosphorylates GR and PPAR gamma to reciprocall...
- Characterization of Novel Peroxisome Proliferator-activated Receptor gamma Coactivator-1 alpha (PGC-1 alpha) Isoform in Human Liver
[作者:Felder, TK; Soyal, SM; Oberkofler, H; Hahne, P; Auer, S; Weiss, R; Gadermaier, G; Miller, K; Krempler, F; Esterbauer, H; Patsch, W,期刊:Journal of Biological Chemistry, 页码:42923-42936 , 文章类型: Article,,卷期:2011年286-50]
- Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) is a transcriptional coactivator that contributes to the regulation of numerous transcriptional programs including the hepatic response t...
- Selenoprotein K Binds Multiprotein Complexes and Is Involved in the Regulation of Endoplasmic Reticulum Homeostasis
[作者:Shchedrina, VA; Everley, RA; Zhang, Y; Gygi, SP; Hatfield, DL; Gladyshev, VN,期刊:Journal of Biological Chemistry, 页码:42937-42948 , 文章类型: Article,,卷期:2011年286-50]
- Background: Selenoprotein K (SelK) is an endoplasmic reticulum (ER) protein of unknown function. Results: SelK associates with proteins involved in elimination of misfolded proteins from the ER. Conclusion: SelK is a fun...
- Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor
[作者:Garbers, C; Thaiss, W; Jones, GW; Waetzig, GH; Lorenzen, I; Guilhot, F; Lissilaa, R; Ferlin, WG; Grotzinger, J; Jones, SA; Rose-John, S; Scheller, J,期刊:Journal of Biological Chemistry, 页码:42959-42970 , 文章类型: Article,,卷期:2011年286-50]
- Background: IL-6 trans-signaling plays a critical role in chronic inflammation and cancer. Results: The trans-signaling inhibitor sgp130(Fc) also inhibits classic signaling depending on IL-6/sIL-6R ratios. Conclusion: Th...
- Structural Basis for Partial Redundancy in a Class of Transcription Factors, the LIM Homeodomain Proteins, in Neural Cell Type Specification
[作者:Gadd, MS; Bhati, M; Jeffries, CM; Langley, DB; Trewhella, J; Guss, JM; Matthews, JM,期刊:Journal of Biological Chemistry, 页码:42971-42980 , 文章类型: Article,,卷期:2011年286-50]
- Background: Lhx and Isl proteins contribute to genetic control in developing neurons. Results: The Lhx3/4-binding motif in Isl2 was identified, and the structures of Lhx-Isl complexes were characterized and compared. Con...
- TLR2 and RIP2 Pathways Mediate Autophagy of Listeria monocytogenes via Extracellular Signal-regulated Kinase (ERK) Activation
[作者:Anand, PK; Tait, SWG; Lamkanfi, M; Amer, AO; Nunez, G; Pages, G; Pouyssegur, J; McGargill, MA; Green, DR; Kanneganti, TD,期刊:Journal of Biological Chemistry, 页码:42981-42991 , 文章类型: Article,,卷期:2011年286-50]
- Background: Listeria monocytogenes is an intracellular pathogen that invades the host cytoplasm. Results: Cells deficient in TLR2 and NOD2 show defective autophagy of Listeria monocytogenes. Conclusion: Autophagy of List...
- Ethylmalonyl-CoA Decarboxylase, a New Enzyme Involved in Metabolite Proofreading
[作者:Linster, CL; Noel, G; Stroobant, V; Vertommen, D; Vincent, MF; Bommer, GT; Veiga-da-Cunha, M; Van Schaftingen, E,期刊:Journal of Biological Chemistry, 页码:42992-43003 , 文章类型: Article,,卷期:2011年286-50]
- Background: Acetyl-CoA and propionyl-CoA carboxylases slowly form ethylmalonyl-CoA as a side activity. Results: Anew enzyme, ethylmalonyl-CoA decarboxylase, was identified in mammalian tissues and shown to be encoded by ...
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