- Mammalian Target of Rapamycin Complex 2 (mTORC2) Negatively Regulates Toll-like Receptor 4-mediated Inflammatory Response via FoxO1
[作者:Brown, J; Wang, HZ; Suttles, J; Graves, DT; Martin, M,期刊:Journal of Biological Chemistry, 页码:44295-44305 , 文章类型: Article,,卷期:2011年286-52]
- Activation of the PI3K pathway plays a pivotal role in regulating the inflammatory response. The loss of mTORC2 has been shown to abrogate the activation of Akt, a critical downstream component of PI3K signaling. However...
- Testis-specific miRNA-469 Up-regulated in Gonadotropin-regulated Testicular RNA Helicase (GRTH/DDX25)-null Mice Silences Transition Protein 2 and Protamine 2 Messages at Sites within Coding Region IMPLICATIONS OF ITS ROLE IN GERM CELL DEVELOPMENT
[作者:Dai, LS; Tsai-Morris, CH; Sato, H; Villar, J; Kang, JH; Zhang, JB; Dufau, ML,期刊:Journal of Biological Chemistry, 页码:44306-44318 , 文章类型: Article,,卷期:2011年286-52]
- Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25), a testis-specific member of the DEAD-box family, is an essential post-transcriptional regulator of spermatogenesis. Failure of expression of Transition protein...
- Aquaporin-9 Protein Is the Primary Route of Hepatocyte Glycerol Uptake for Glycerol Gluconeogenesis in Mice
[作者:Jelen, S; Wacker, S; Aponte-Santamaria, C; Skott, M; Rojek, A; Johanson, U; Kjellbom, P; Nielsen, S; de Groot, BL; Rutzler, M,期刊:Journal of Biological Chemistry, 页码:44319-44325 , 文章类型: Article,,卷期:2011年286-52]
- It has been hypothesized that aquaporin-9 (AQP9) is part of the unknown route of hepatocyte glycerol uptake. In a previous study, leptin receptor-deficient wild-type mice became diabetic and suffered from fasting hypergl...
- Glucocorticoids and Tumor Necrosis Factor alpha Increase Oxidative Stress and Suppress Wnt Protein Signaling in Osteoblasts
[作者:Almeida, M; Han, L; Ambrogini, E; Weinstein, RS; Manolagas, SC,期刊:Journal of Biological Chemistry, 页码:44326-44335 , 文章类型: Article,,卷期:2011年286-52]
- Endogenous glucocorticoids (GCs) and inflammatory cytokines contribute to the age-associated loss of bone mass and strength, but the molecular mechanisms responsible for their deleterious effects on the aging skeleton ar...
- FHL2 Protein Is a Novel Co-repressor of Nuclear Receptor Nur77
[作者:Kurakula, K; van der Wal, E; Geerts, D; van Tiel, CM; de Vries, CJM,期刊:Journal of Biological Chemistry, 页码:44336-44343 , 文章类型: Article,,卷期:2011年286-52]
- The three members of the NR4A orphan nuclear receptor subfamily Nur77, Nurr1, and NOR-1, regulate a variety of biological functions including vascular disease and metabolism. In this study, we identified Four and a half ...
- Functional Analysis of C-type Lysozyme in Penaeid Shrimp
[作者:Kaizu, A; Fagutao, FF; Kondo, H; Aoki, T; Hirono, I,期刊:Journal of Biological Chemistry, 页码:44344-44349 , 文章类型: Article,,卷期:2011年286-52]
- Lysozyme is an enzyme that cleaves the beta-1,4-glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan, leading to bacterial lysis. Recently, lysozyme has been found to have anti-HIV an...
- Thromboxane Receptor Signaling Is Required for Fibronectin-induced Matrix Metalloproteinase 9 Production by Human and Murine Macrophages and Is Attenuated by the Arhgef1 Molecule
[作者:Hartney, JM; Gustafson, CE; Bowler, RP; Pelanda, R; Torres, RM,期刊:Journal of Biological Chemistry, 页码:44521-44531 , 文章类型: Article,,卷期:2011年286-52]
- During an inflammatory response, resident and newly recruited tissue macrophages adhere to extracellular matrix and cell-bound integrin ligands. This interaction induces the expression of pro-inflammatory mediators that ...
- SOD1 (Copper/Zinc Superoxide Dismutase) Deficiency Drives Amyloid beta Protein Oligomerization and Memory Loss in Mouse Model of Alzheimer Disease
[作者:Murakami, K; Murata, N; Noda, Y; Tahara, S; Kaneko, T; Kinoshita, N; Hatsuta, H; Murayama, S; Barnham, KJ; Irie, K; Shirasawa, T; Shimizu, T,期刊:Journal of Biological Chemistry, 页码:44557-44568 , 文章类型: Article,,卷期:2011年286-52]
- Oxidative stress is closely linked to the pathogenesis of neurodegeneration. Soluble amyloid beta (A beta) oligomers cause cognitive impairment and synaptic dysfunction in Alzheimer disease (AD). However, the relationshi...
- Comparison of Presenilin 1 and Presenilin 2 gamma-Secretase Activities Using a Yeast Reconstitution System
[作者:Yonemura, Y; Futai, E; Yagishita, S; Suo, S; Tomita, T; Iwatsubo, T; Ishiura, S,期刊:Journal of Biological Chemistry, 页码:44569-44575 , 文章类型: Article,,卷期:2011年286-52]
- gamma-Secretase is composed of at least four proteins, presenilin (PS), nicastrin (NCT), Aph1, and Pen2. PS is the catalytic subunit of the gamma-secretase complex, having aspartic protease activity. PS has two homologs,...
- Polarity-regulating Kinase Partitioning-defective 1b (PAR1b) Phosphorylates Guanine Nucleotide Exchange Factor H1 (GEF-H1) to Regulate RhoA-dependent Actin Cytoskeletal Reorganization
[作者:Yamahashi, Y; Saito, Y; Murata-Kamiya, N; Hatakeyama, M,期刊:Journal of Biological Chemistry, 页码:44576-44584 , 文章类型: Article,,卷期:2011年286-52]
- Partitioning-defective 1b (PAR1b), also known as microtubule affinity-regulating kinase 2 (MARK2), is a member of evolutionally conserved PAR1/MARK serine/threonine kinase family, which plays a key role in the establishm...
- PPAR delta Coordinates Angiotensin II-induced Senescence in Vascular Smooth Muscle Cells through PTEN-mediated Inhibition of Superoxide Generation
[作者:Kim, HJ; Ham, SA; Kim, MY; Hwang, JS; Lee, H; Kang, ES; Yoo, T; Woo, IS; Yabe-Nishimura, C; Paek, KS; Kim, JH; Seo, HG,期刊:Journal of Biological Chemistry, 页码:44585-44593 , 文章类型: Article,,卷期:2011年286-52]
- Cellular senescence-associated changes in blood vessels have been implicated in aging and age-related cardiovascular disorders. Here, we demonstrate that peroxisome proliferator-activated receptor (PPAR) delta coordinate...
- Determination of Target Sequence Bound by PapX, Repressor of Bacterial Motility, in flhD Promoter Using Systematic Evolution of Ligands by Exponential Enrichment (SELEX) and High Throughput Sequencing
[作者:Reiss, DJ; Mobley, HLT,期刊:Journal of Biological Chemistry, 页码:44726-44738 , 文章类型: Article,,卷期:2011年286-52]
- Most uncomplicated urinary tract infections (UTIs) are caused by uropathogenic Escherichia coli (UPEC). Both motility and adherence are integral to UTI pathogenesis, yet they represent opposing forces. Therefore, it is l...
- Mas-related Gene X2 (MrgX2) Is a Novel G Protein-coupled Receptor for the Antimicrobial Peptide LL-37 in Human Mast Cells RESISTANCE TO RECEPTOR PHOSPHORYLATION, DESENSITIZATION, AND INTERNALIZATION
[作者:Subramanian, H; Gupta, K; Guo, Q; Price, R; Ali, H,期刊:Journal of Biological Chemistry, 页码:44739-44749 , 文章类型: Article,,卷期:2011年286-52]
- Human LL-37 is a multifunctional antimicrobial peptide that promotes inflammation, angiogenesis, wound healing, and tumor metastasis. Most effects of LL-37 are mediated via the activation of the cell surface G protein-co...
- Nuclear Factor kappa B Subunits RelB and cRel Negatively Regulate Toll-like Receptor 3-mediated beta-Interferon Production via Induction of Transcriptional Repressor Protein YY1
[作者:Siednienko, J; Maratha, A; Yang, S; Mitkiewicz, M; Miggin, SM; Moynagh, PN,期刊:Journal of Biological Chemistry, 页码:44750-44763 , 文章类型: Article,,卷期:2011年286-52]
- The induction of beta-interferon (IFN-beta) is a key anti-viral response to infection by RNA viruses. Virus-induced expression of IFN-beta requires the co-operative action of the transcription factors IRF-3/7, NF-kappa B...
|