- Development of Fluorescent Ligands for the Human 5-HT1A Receptor
[作者:ALONSO DULCE; VAZQUEZVILLA HENAR; GAMO ANA M; MARTINEZESPERON MARIA F; TORTOSA MARIOLA; VISO ALMA; FERNANDEZ DE LA PRADILLA ROBERTO; JUNQUERA ELENA; AICART EMILIO; MARTINFONTECHA MAR; BENHAMU BELLINDA; LOPEZRODRIGUEZ MARIA L; ORTEGAGUTIERREZ SILVIA,期刊:ACS Medicinal Chemistry Letters, 页码:249-253 , 文章类型: Article,,卷期:2010年1-6]
- In this work, we report the design and synthesis of a set of fluorescent probes targeting the human 5-HT1A receptor (h5-HT1AR). Among the synthesized compounds, derivative 4 deserves special attention as being a high-aff...
- Carbamylation of N-Terminal Proline
[作者:OLAJUYIGBE FOLASADE M; DEMITRI NICOLA; AJELE JOSHUA O; MAURIZIO ELISA; RANDACCIO LUCIO; GEREMIA SILVANO,期刊:ACS Medicinal Chemistry Letters, 页码:254-257 , 文章类型: Article,,卷期:2010年1-6]
- Protein carbamylation is of great concern both in vivo and in vitro. Here, we report the first structural characterization of a protein carbamylated at the N-terminal proline. The unexpected carbamylation of the a-amino ...
- KSRP/FUBP2 Is a Binding Protein of GO-Y086, a Cytotoxic Curcumin Analogue
[作者:YAMAKOSHI HIROYUKI; KANOH NAOKI; KUDO CHIEKO; SATO ATSUKO; UEDA KAZUNORI; MUROI MAKOTO; KON SHUNSUKE; SATAKE MASANOBU; OHORI HISATSUGU; ISHIOKA CHIKASHI; OSHIMA YOSHITERU; OSADA HIROYUKI; CHIBA NATSUKO; SHIBATA HIROYUKI; IWABUCHI YOSHIHARU,期刊:ACS Medicinal Chemistry Letters, 页码:273-276 , 文章类型: Article,,卷期:2010年1-6]
- Bis(arylmethylidene)acetone derivatives are an important class of curcumin analogues that exhibit various biological and pharmacological activities. We herein report that GO-Y086, a biotinylated bis(arylmethylidene)aceto...
- Synthesis and Biochemical Testing of 3-(Carboxyphenylethyl)imidazo[2,1-f][1,2,4]triazines as Inhibitors of AMP Deaminase
[作者:LINDELL STEPHEN D; MAECHLING SIMON; SABINA RICHARD L,期刊:ACS Medicinal Chemistry Letters, 页码:286-289 , 文章类型: Article,,卷期:2010年1-6]
- C-Ribosyl imidazo[2,1-f][1,2,4]triazines and 3-[2-(3-carboxypheny1)ethyl]-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diaze pin-8-ols represent two classes of known AMP deaminase inhibitors. A combination of the aglycone from t...
- Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist
[作者:NEGORO NOBUYUKI; SASAKI SHINOBU; MIKAMI SATOSHI; ITO MASAHIRO; SUZUKI MASAMI; TSUJIHATA YOSHIYUKI; ITO RYO; HARADA AYAKO; TAKEUCHI KOJI; SUZUKI NOBUHIRO; MIYAZAKI JUNICHI; SANTOU TAKASHI; ODANI TOMOYUKI; KANZAKI NAOYUKI; FUNAMI MIYUKI; TANAKA TOSHIMASA; KOGAME AKIFUMI; MATSUNAGA SHINICHIRO; YASUMA TSUNEO; MOMOSE YU,期刊:ACS Medicinal Chemistry Letters, 页码:290-294 , 文章类型: Article,,卷期:2010年1-6]
- GPR40, one of the G protein-coupled receptors predominantly expressed in pancreatic beta-cells, mediates enhancement of glucose-stimulated insulin secretion by free fatty acids. A potent and selective GPR40 agonist is th...
|