- The Trans-autostimulatory Activity of Rad27 Suppresses dna2 Defects in Okazaki Fragment Processing
[作者:Munashingha, PR; Lee, CH; Kang, YH; Shin, YK; Nguyen, TA; Seo, YS,期刊:Journal of Biological Chemistry, 页码:8675-8687 , 文章类型: Article,,卷期:2012年287-12]
- Dna2 and Rad27 (yeast Fen1) are the two endonucleases critical for Okazaki fragment processing during lagging strand DNA synthesis that have been shown to interact genetically and physically. In this study, we addressed ...
- The Growth-Suppressive Function of the Polycomb Group Protein Polyhomeotic Is Mediated by Polymerization of Its Sterile Alpha Motif (SAM) Domain
[作者:Robinson, AK; Leal, BZ; Chadwell, LV; Wang, RJ; Ilangovan, U; Kaur, Y; Junco, SE; Schirf, V; Osmulski, PA; Gaczynska, M; Hinck, AP; Demeler, B; McEwen, DG; Kim, CA,期刊:Journal of Biological Chemistry, 页码:8702-8713 , 文章类型: Article,,卷期:2012年287-12]
- Polyhomeotic (Ph), a member of the Polycomb Group (PcG), is a gene silencer critical for proper development. We present a previously unrecognized way of controlling Ph function through modulation of its sterile alpha mot...
- PP6 Regulatory Subunit R1 Is Bidentate Anchor for Targeting Protein Phosphatase-6 to DNA-dependent Protein Kinase
[作者:Hosing, AS; Valerie, NCK; Dziegielewski, J; Brautigan, DL; Larner, JM,期刊:Journal of Biological Chemistry, 页码:9230-9239 , 文章类型: Article,,卷期:2012年287-12]
- DNA-dependent protein kinase (DNA-PK) becomes activated in response toDNAdouble strand breaks, initiating repair by the non-homologous end joining pathway. DNA.PK complexes with the regulatory subunit SAPSR1 (R1) of prot...
- Human alpha/beta Hydrolase Domain Containing 10 (ABHD10) Is Responsible Enzyme for Deglucuronidation of Mycophenolic Acid Acyl-glucuronide in Liver
[作者:Iwamura, A; Fukami, T; Higuchi, R; Nakajima, M; Yokoi, T,期刊:Journal of Biological Chemistry, 页码:9240-9249 , 文章类型: Article,,卷期:2012年287-12]
- Mycophenolic acid (MPA), the active metabolite of the immunosuppressant mycophenolate mofetil (MMF), is primarily metabolized by glucuronidation to a phenolic glucuronide (MPAG) and an acyl glucuronide (AcMPAG). It is kn...
- Two Distinct States of Escherichia coli Cells That Overexpress Recombinant Heterogeneous beta-Galactosidase
[作者:Zhao, Y; He, W; Liu, WF; Liu, CC; Feng, LK; Sun, L; Yan, YB; Hang, HY,期刊:Journal of Biological Chemistry, 页码:9259-9268 , 文章类型: Article,,卷期:2012年287-12]
- The mechanism by which inclusion bodies form is still not well understood, partly because the dynamic processes of the inclusion body formation and its solubilization have hardly been investigated at an individual cell l...
- Identification of Small Molecule Inhibitors of Neurite Loss Induced by A beta peptide using High Content Screening
[作者:Ofengeim, D; Shi, P; Miao, BC; Fan, J; Xia, XF; Fan, YB; Lipinski, MM; Hashimoto, T; Polydoro, M; Yuan, JY; Wong, STC; Degterev, A,期刊:Journal of Biological Chemistry, 页码:8714-8723 , 文章类型: Article,,卷期:2012年287-12]
- Multiple lines of evidence indicate a strong relationship between A beta peptide-induced neurite degeneration and the progressive loss of cognitive functions in Alzheimer disease (AD) patients and in AD animal models. Th...
- RAD51 Protein ATP Cap Regulates Nucleoprotein Filament Stability
[作者:Amunugama, R; He, YJ; Willcox, S; Forties, RA; Shim, KS; Bundschuh, R; Luo, Y; Griffith, J; Fishel, R,期刊:Journal of Biological Chemistry, 页码:8724-8736 , 文章类型: Article,,卷期:2012年287-12]
- RAD51 mediates homologous recombination by forming an active DNA nucleoprotein filament (NPF). A conserved aspartate that forms a salt bridge with the ATP gamma-phosphate is found at the nucleotide-binding interface betw...
- Sphingoid Bases and the Serine Catabolic Enzyme CHA1 Define a Novel Feedforward/Feedback Mechanism in the Response to Serine Availability
[作者:Montefusco, DJ; Newcomb, B; Gandy, JL; Brice, SE; Matmati, N; Cowart, LA; Hannun, YA,期刊:Journal of Biological Chemistry, 页码:9280-9289 , 文章类型: Article,,卷期:2012年287-12]
- Targets of bioactive sphingolipids in Saccharomyces cerevisiae were previously identified using microarray experiments focused on sphingolipid-dependent responses to heat stress. One of these heat-induced genes is the se...
- FoxO1 Protein Cooperates with ATF4 Protein in Osteoblasts to Control Glucose Homeostasis
[作者:Kode, A; Mosialou, I; Silva, BC; Joshi, S; Ferron, M; Rached, MT; Kousteni, S,期刊:Journal of Biological Chemistry, 页码:8757-8768 , 文章类型: Article,,卷期:2012年287-12]
- The Forkhead transcription factor FoxO1 inhibits through its expression in osteoblasts beta-cell proliferation, insulin secretion, and sensitivity. At least part of the FoxO1 metabolic functions result from its ability t...
- Factor Inhibiting HIF (FIH) Recognizes Distinct Molecular Features within Hypoxia-inducible Factor-alpha (HIF-alpha) versus Ankyrin Repeat Substrates
[作者:Wilkins, SE; Karttunen, S; Hampton-Smith, RJ; Murchland, I; Chapman-Smith, A; Peet, DJ,期刊:Journal of Biological Chemistry, 页码:8769-8781 , 文章类型: Article,,卷期:2012年287-12]
- Factor Inhibiting HIF (FIH) catalyzes the beta-hydroxylation of asparagine residues in HIF-alpha transcription factors as well as ankyrin repeat domain (ARD) proteins such as Notch and Gankyrin. Although FIH-mediated hyd...
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