- Mdm2's Dilemma: To Degrade or To Translate p53?
[作者:Hamard, PJ; Manfredi, JJ,期刊:Cancer Cell, 页码:3-5 , 文章类型: Editorial Material,,卷期:2012年21-1]
- In this issue of Cancer Cell, Gajjar et al. provide insight into how Mdm2 can both inhibit and enhance p53 activity. In the basal setting, Mdm2 binds p53 and promotes p53 degradation. Under stress conditions, ATM-depende...
- How to Fool a Wonder Drug: Truncate and Dimerize
[作者:Molina-Arcas, M; Downward, J,期刊:Cancer Cell, 页码:7-9 , 文章类型: Editorial Material,,卷期:2012年21-1]
- In a recent paper, Poulikakos et al. describe a new and potentially common mechanism whereby melanomas develop resistance to the BRAF inhibitor vemurafenib by expressing truncated forms of BRAF(V600E) that can dimerize i...
- Self-Renewal Does Not Predict Tumor Growth Potential in Mouse Models of High-Grade Glioma
[作者:Barrett, LE; Granot, Z; Coker, C; Lavarone, A; Hambardzumyan, D; Holland, EC; Nam, HS; Benezra, R,期刊:Cancer Cell, 页码:11-24 , 文章类型: Article,,卷期:2012年21-1]
- Within high-grade gliomas, the precise identities and functional roles of stem-like cells remain unclear. In the normal neurogenic niche, ID (Inhibitor of DNA-binding) genes maintain self-renewal and multipotency of adul...
- The p53 mRNA-Mdm2 Interaction Controls Mdm2 Nuclear Trafficking and Is Required for p53 Activation following DNA Damage
[作者:Gajjar, M; Candeias, MM; Malbert-Colas, L; Mazars, A; Fujita, J; Olivares-Illana, V; Fahraeus, R,期刊:Cancer Cell, 页码:25-35 , 文章类型: Article,,卷期:2012年21-1]
- The ATM kinase and p53 are key tumor suppressor factors that control the genotoxic stress response pathway. The ATM substrate Mdm2 controls p53 activity by either targeting p53 for degradation or promoting its synthesis ...
- Bile Acid and Inflammation Activate Gastric Cardia Stem Cells in a Mouse Model of Barrett-Like Metaplasia
[作者:Quante, M; Bhagat, G; Abrams, JA; Marache, F; Good, P; Lee, MD; Lee, Y; Friedman, R; Asfaha, S; Dubeykovskaya, Z; Mahmood, U; Figueiredo, JL; Kitajewski, J; Shawber, C; Lightdale, CJ; Rustgi, AK; Wang, TC,期刊:Cancer Cell, 页码:36-51 , 文章类型: Article,,卷期:2012年21-1]
- Esophageal adenocarcinoma (EAC) arises from Barrett esophagus (BE), intestinal-like columnar metaplasia linked to reflux esophagitis. In a transgenic mouse model of BE, esophageal overexpression of interleukin-1 beta phe...
- Endothelial Cell HIF-1 alpha and HIF-2 alpha Differentially Regulate Metastatic Success
[作者:Branco-Price, C; Zhang, N; Schnelle, M; Evans, C; Katschinski, DM; Liao, D; Ellies, L; Johnson, RS,期刊:Cancer Cell, 页码:52-65 , 文章类型: Article,,卷期:2012年21-1]
- The hypoxia inducible transcription factors (HIFs) control many mediators of vascular response, including both angiogenic factors and small molecules such as nitric oxide (NO). In studying how endothelial HIF response it...
- Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway
[作者:Cooke, VG; LeBleu, VS; Keskin, D; Khan, Z; O'Conne, JT; Teng, Y; Duncan, MB; Xie, L; Maeda, G; Vong, S; Sugimoto, H; Rocha, RM; Damascena, A; Brentani, RR; Kalluri, R,期刊:Cancer Cell, 页码:66-81 , 文章类型: Article,,卷期:2012年21-1]
- The functional role of pericytes in cancer progression remains unknown. Clinical studies suggest that low numbers of vessel-associated pericytes correlated with a drop in overall survival of patients with invasive breast...
- Rapid Decrease in Delivery of Chemotherapy to Tumors after Anti-VEGF Therapy: Implications for Scheduling of Anti-Angiogenic Drugs
[作者:Van der Veldt, AAM; Lubberink, M; Bahce, I; Walraven, M; de Boer, MP; Greuter, HNJM; Hendrikse, NH; Eriksson, J; Windhorst, AD; Postmus, PE; Verheul, HM; Serne, EH; Lammertsma, AA; Smit, EF,期刊:Cancer Cell, 页码:82-91 , 文章类型: Article,,卷期:2012年21-1]
- Current strategies combining anti-angiogenic drugs with chemotherapy provide clinical benefit in cancer patients. It is assumed that anti-angiogenic drugs, such as bevacizumab, transiently normalize abnormal tumor vascul...
- CREPT Accelerates Tumorigenesis by Regulating the Transcription of Cell-Cycle-Related Genes
[作者:Lu, DD; Wu, YY; Wang, YY; Ren, FL; Wang, DJ; Su, FQ; Zhang, YQ; Yang, X; Jin, GH; Hao, XB; He, DC; Zhai, YG; Irwin, DM; Hu, J; Sung, JJY; Yu, J; Jia, BQ; Chang, ZJ,期刊:Cancer Cell, 页码:92-104 , 文章类型: Article,,卷期:2012年21-1]
- Tumorigenesis is caused by an uncontrolled cell cycle and the altered expression of many genes. Here, we report a gene CREPT that is preferentially expressed in diverse human tumors. Overexpression of CREPT accelerates t...
- Kras(G12D)-Induced IKK2/beta/NF-kappa B Activation by IL-1 alpha and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma
[作者:Ling, JH; Kang, YA; Zhao, RY; Xia, QH; Lee, DF; Chang, Z; Li, J; Peng, BL; Fleming, JB; Wang, HM; Liu, JS; Lemischka, IR; Hung, MC; Chiao, PJ,期刊:Cancer Cell, 页码:105-120 , 文章类型: Article,,卷期:2012年21-1]
- Constitutive Kras and NF-kappa B activation is identified as signature alterations in pancreatic ductal adenocarcinoma (PDAC). However, how NF-kappa B is activated in PDAC is not yet understood. Here, we report that panc...
- Polycomb-Mediated Loss of miR-31 Activates NIK-Dependent NF-kappa B Pathway in Adult T Cell Leukemia and Other Cancers
[作者:Yamagishi, M; Nakano, K; Miyake, A; Yamochi, T; Kagami, Y; Tsutsumi, A; Matsuda, Y; Sato-Otsubo, A; Muto, S; Utsunomiya, A; Yamaguchi, K; Uchimaru, K; Ogawa, S; Watanabe, T,期刊:Cancer Cell, 页码:121-135 , 文章类型: Article,,卷期:2012年21-1]
- Constitutive NF-kappa B activation has causative roles in adult T cell leukemia (ATL) caused by HTLV-1 and other cancers. Here, we report a pathway involving Polycomb-mediated miRNA silencing and NF-kappa B activation. W...
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