- TGF beta induces proHB-EGF shedding and EGFR transactivation through ADAM activation in gastric cancer cells
[作者:Ebi, M; Kataoka, H; Shimura, T; Kubota, E; Hirata, Y; Mizushima, T; Mizoshita, T; Tanaka, M; Mabuchi, M; Tsukamoto, H; Tanida, S; Kamiya, T; Higashiyama, S; Joh, T,期刊:Biochemical and Biophysical Research Communications, 页码:449-454 , 文章类型: Article,,卷期:2010年402-3]
- Background and aims Transforming growth factor-beta (TGF beta) is known to potently inhibit cell growth Loss of responsiveness to TGB beta inhibition on cell growth is a hallmark of many types of cancer, yet its mechanis...
- Site-specific protein backbone and side-chain NMR chemical shift and relaxation analysis of human vinexin SH3 domain using a genetically encoded N-15/F-19-labeled unnatural amino acid
[作者:Shi, P; Xi, ZY; Wang, H; Shi, CW; Xiong, Y; Tian, CL,期刊:Biochemical and Biophysical Research Communications, 页码:461-466 , 文章类型: Article,,卷期:2010年402-3]
- SH3 is a ubiquitous domain mediating protein-protein interactions Recent solution NMR structural studies have shown that a proline-rich peptide is capable of binding to the human vinexin SH3 domain Here, an orthogonal am...
- Stimulation of Na+/K+ ATPase activity and Na+ coupled glucose transport by beta-catenin
[作者:Sopjani, M; Alesutan, I; Wilmes, J; Dermaku-Sopjani, M; Lam, RS; Koutsouki, E; Jakupi, M; Foller, M; Lang, F,期刊:Biochemical and Biophysical Research Communications, 页码:467-470 , 文章类型: Article,,卷期:2010年402-3]
- beta-Catenin is a multifunctional protein stimulating as oncogenic transcription factor several genes important for cell proliferation beta-Catenin-regulated genes include the serum- and glucocorticoid-inducible kinase S...
- Activation of VPAC(1) receptors aggravates early atherosclerosis in hypercholesterolemic apolipoprotein E-deficient mice
[作者:Sheikine, Y; Deodato, B; Olofsson, PS; Soderstrom, LA; Lundberg, AM; Bodin, I; Rudling, M; Theodorsson, E; Hansson, GK,期刊:Biochemical and Biophysical Research Communications, 页码:471-476 , 文章类型: Article,,卷期:2010年402-3]
- Objective Vasoactive intestinal peptide (VIP) is a 28-amino acid peptide widely expressed in the body and binding three types of receptors VPAC(1)-R, VPAC(2)-R and PAC(1)-R Based on beneficial effects of VIP and VPAC(1)-...
- PPAR gamma activates ABCA1 gene transcription but reduces the level of ABCA1 protein in HepG2 cells
[作者:Mogilenko, DA; Shavva, VS; Dizhe, EB; Orlov, SV; Perevozchikov, AP,期刊:Biochemical and Biophysical Research Communications, 页码:477-482 , 文章类型: Article,,卷期:2010年402-3]
- Synthesis of ABCA1 protein in liver is necessary for high-density lipoproteins (HDL) formation in mammals Nuclear receptor PPAR gamma is known as activator of ABCA1 expression, but details of PPAR gamma-mediated regulati...
- Tracking of fast moving neuronal vesicles with ageladine A
[作者:Bickmeyer, U; Heine, M; Podbielski, I; Mund, D; Kock, M; Karuso, P,期刊:Biochemical and Biophysical Research Communications, 页码:489-494 , 文章类型: Article,,卷期:2010年402-3]
- Ageladine A is a marine natural product that can be used to fluorescently stain living tissues and cells Its fluorescence is highly pH dependent with the highest intensities under acidic conditions We have used ageladine...
- Generation and characterization of T1R2-LacZ knock-in mouse
[作者:Iwatsuki, K; Nomura, M; Shibata, A; Ichikawa, R; Enciso, PLM; Wang, LX; Takayanagi, R; Torii, K; Uneyama, H,期刊:Biochemical and Biophysical Research Communications, 页码:495-499 , 文章类型: Article,,卷期:2010年402-3]
- Taste cells are chemosensory epithelial cells that sense distinct taste quality such as umami, sweet, bitter, sour and salty. Taste cells utilize G protein-coupled receptors to detect umami, sweet and bitter taste wherea...
- Therapeutic effect of IL-12/23 and their signaling pathway blockade on brain ischemia model
[作者:Konoeda, F; Shichita, T; Yoshida, H; Sugiyama, Y; Muto, G; Hasegawa, E; Morita, R; Suzuki, N; Yoshimura, A,期刊:Biochemical and Biophysical Research Communications, 页码:500-506 , 文章类型: Article,,卷期:2010年402-3]
- Recently, T cell cytokines such as IL-17 and IFN-gamma have been shown to play important roles in the progression of brain injury induced by ischemia We have shown that IL-23 from infiltrated macrophages activates gamma ...
- CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine
[作者:Liu, WB; Ao, L; Zhou, ZY; Cui, ZH; Zhou, YH; Yuan, XY; Xiang, YL; Cao, J; Liu, JY,期刊:Biochemical and Biophysical Research Communications, 页码:507-514 , 文章类型: Article,,卷期:2010年402-3]
- The epigenetic mechanisms underlying the tumorigenesis caused by polycyclic aromatic hydrocarbons and nitrosamine compounds such as 3-methylcholanthrene (MCA) and diethylnitrosamine (DEN) are currently unknown We reporte...
- An improved method for enhanced production and biological activity of human secretory leukocyte protease inhibitor (SLPI) in Pichia pastoris
[作者:Li, ZG; Moy, A; Gomez, SR; Franz, AH; Lin-Cereghino, J; Lin-Cereghino, GP,期刊:Biochemical and Biophysical Research Communications, 页码:519-524 , 文章类型: Article,,卷期:2010年402-3]
- The human secretory leukocyte protease inhibitor (SLPI) is an 11 7 kD cysteine-rich protein that has been shown to possess anti-protease, anti-inflammatory, and antimicrobial properties By using a Pichia pastoris strain ...
- 4 '-Acetoamido-4-hydroxychalcone, a chalcone derivative, inhibits glioma growth and invasion through regulation of the tropomyosin 1 gene
[作者:Ku, BM; Ryu, HW; Lee, YK; Ryu, J; Jeong, JY; Choi, J; Cho, HJ; Park, KH; Kang, SS,期刊:Biochemical and Biophysical Research Communications, 页码:525-530 , 文章类型: Article,,卷期:2010年402-3]
- Chalcones are precursors of flavonoids and have been shown to have anti-cancer activity Here, we identify the synthetic chalcone derivative 4'-acetoamido-4-hydroxychalcone (ARC) as a potential therapeutic agent for the t...
- Inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by N-(p-amylcinnamoyl)anthranilic acid (ACA)
[作者:Gwanyanya, A; Macianskiene, R; Bito, V; Sipido, KR; Vereecke, J; Mubagwa, K,期刊:Biochemical and Biophysical Research Communications, 页码:531-536 , 文章类型: Article,,卷期:2010年402-3]
- N-(p-amylcinnamoyl)anthrandic acid (ACA), a phospholipase A(2) (PLA(2)) inhibitor, is structurally-related to non-steroidal anti-inflammatory drugs (NSAIDs) of the fenamate group and may also modulate various ion channel...
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