- The critical distance for the cycloaromatization reactions of enediynes
[作者:Capitani, JF; Gaffney, SM; Castaldo, L; Mitra, A,期刊:Current Topics in Medicinal Chemistry, 页码:470-486 , 文章类型: Review,,卷期:2008年8-6]
It has been shown that the enediyne anticancer antibiotics e. g., calicheamicin, neocarzinostatin and others cleave DNA via the putative intermediate 1,4-diradical formed in the Bergmann cyclization and are thus usefu...
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