- Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-Like Tyrosine Kinase 3 Receptor (FLT3) and Multi-Targeted Kinase Inhibitor, in Patients With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome With Either Wild-Type or Mutated FLT3
[作者:Fischer, T; Stone, RM; DeAngelo, DJ; Galinsky, I; Estey, E; Lanza, C; Fox, E; Ehninger, G; Feldman, EJ; Schiller, GJ; Klimek, VM; Nimer, SD; Gilliland, DG; Dutreix, C; Huntsman-Labed, A; Virkus, J; Giles, FJ,期刊:Journal of clinical oncology, 页码:4339-4345 , 文章类型: Article,,卷期:2010年28-28]
- Purpose Mutations leading to constitutive activation of the FMS-like tyrosine kinase 3 receptor (FLT3) occur in blasts of 30% of patients with acute myeloid leukemia (AML). Midostaurin (PKC412; N-benzoylstaurosporin) is ...
- Trastuzumab Treatment in T1ab, Node-Negative, Human Epidermal Growth Factor Receptor 2-Overexpressing Breast Carcinomas
[作者:Rodrigues, MJ; Wassermann, J; Albiges, L; Brain, E; Delaloge, S; Stevens, D; Guinebretiere, JM; Mathieu, MC; Kirova, Y; Guillot, E; Vincent-Salomon, A; Cottu, PH,期刊:Journal of clinical oncology, 页码:E541-E542 , 文章类型: Letter,,卷期:2010年28-28]
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- Metastatic Mucinous Tubular and Spindle Cell Carcinoma of the Kidney Responding to Sunitinib
[作者:Larkin, J; Fisher, R; Pickering, L; Thway, K; Livni, N; Fisher, C; Gore, M,期刊:Journal of clinical oncology, 页码:E539-E540 , 文章类型: Letter,,卷期:2010年28-28]
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- Tumor Antigen-Targeted, Monoclonal Antibody-Based Immunotherapy: Clinical Response, Cellular Immunity, and Immunoescape
[作者:Ferris, RL; Jaffee, EM; Ferrone, S,期刊:Journal of clinical oncology, 页码:4390-4399 , 文章类型: Article,,卷期:2010年28-28]
Purpose Tumor antigen (TA) -targeted monoclonal antibodies (mAb), rituximab, trastuzumab, and cetuximab, are clinically effective for some advanced malignancies, especially in conjunction with chemotherapy and/or radi...
- Molecular Anatomy of Breast Cancer Stroma and Its Prognostic Value in Estrogen Receptor-Positive and -Negative Cancers
[作者:Bianchini, G; Qi, YA; Alvarez, RH; Iwamoto, T; Coutant, C; Ibrahim, NK; Valero, V; Cristofanilli, M; Green, MC; Radvanyi, L; Hatzis, C; Hortobagyi, GN; Andre, F; Gianni, L; Symmans, WF; Pusztai, L,期刊:Journal of clinical oncology, 页码:4316-4323 , 文章类型: Article,,卷期:2010年28-28]
- Purpose The purpose of this study was to identify genes enriched in breast cancer stroma, assess the stromal gene expression differences between estrogen receptor (ER) -positive and -negative cancers, and separately dete...
- Multivitamin Use Is Not Associated With Cancer Recurrence or Survival in Patients With Stage III Colon Cancer: Findings From CALGB 89803
[作者:Ng, K; Meyerhardt, JA; Chan, JA; Niedzwiecki, D; Hollis, DR; Saltz, LB; Mayer, RJ; Benson, AB; Schaefer, PL; Whittom, R; Hantel, A; Goldberg, RM; Fuchs, CS,期刊:Journal of clinical oncology, 页码:4354-4363 , 文章类型: Article,,卷期:2010年28-28]
- Purpose Multivitamin use is widespread in the United States, especially among patients with cancer. However, the influence of multivitamin supplementation on cancer recurrence and death after a curative resection of colo...
- No Prognostic Impact of the WT1 Gene Single Nucleotide Polymorphism rs16754 in Pediatric Acute Myeloid Leukemia
[作者:Hollink, IHIM; van den Heuvel-Eibrink, MM; Zimmermann, M; Balgobind, BV; Arentsen-Peters, STCJM; Alders, M; Willasch, A; Kaspers, GJJL; Trka, J; Baruchel, A; Creutzig, U; Pieters, R; Reinhardt, D; Zwaan, CM,期刊:Journal of clinical oncology, 页码:E523-E526 , 文章类型: Letter,,卷期:2010年28-28]
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- Pretreatment Quality of Life As a Predictor of Distant Metastasis and Survival for Patients With Nasopharyngeal Carcinoma
[作者:Fang, FM; Tsai, WL; Chien, CY; Chen, HC; Hsu, HC; Huang, TL; Lee, TF; Huang, HY; Lee, CH,期刊:Journal of clinical oncology, 页码:4384-4389 , 文章类型: Article,,卷期:2010年28-28]
- Purpose The purpose of this study was to examine the prognostic value of pretreatment quality of life (QoL) data on locoregional control (LRC), distant metastasis-free survival (DMFS), and overall survival (OS) in patien...
- HER2 and Chromosome 17 Effect on Patient Outcome in the N9831 Adjuvant Trastuzumab Trial
[作者:Perez, EA; Reinholz, MM; Hillman, DW; Tenner, KS; Schroeder, MJ; Davidson, NE; Martino, S; Sledge, GW; Harris, LN; Gralow, JR; Dueck, AC; Ketterling, RP; Ingle, JN; Lingle, WL; Kaufman, PA; Visscher, DW; Jenkins, RB,期刊:Journal of clinical oncology, 页码:4307-4315 , 文章类型: Article,,卷期:2010年28-28]
- Purpose We examined associations between tumor characteristics (human epidermal growth factor receptor 2 [HER2] protein expression, HER2 gene and chromosome 17 copy number, hormone receptor status) and disease-free survi...
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