- Novel polymer carriers and gene constructs for treatment of myocardial ischemia and infarction
[作者:Yockman, JW; Kastenmeier, A; Erickson, HM; Brumbach, JG; Whitten, MG; Albanil, A; Li, DY; Kim, SW; Bull, DA,期刊:Journal of controlled release, 页码:260-266 , 文章类型: Article,,卷期:2008年132-3]
- The number one cause of mortality in the US is cardiovascular related disease. Future predictions do not see a reduction in this rate especially with the continued rise in obesity [P. Poirier, et al., Obesity and cardiov...
- New strategies for nucleic acid delivery to conquer cellular and nuclear membranes
[作者:Lentacker, I; Vandenbroucke, RE; Lucas, B; Demeester, J; De Smedt, SC; Sanders, NN,期刊:Journal of controlled release, 页码:279-288 , 文章类型: Article,,卷期:2008年132-3]
- After administration to the body, nucleic acid containing nanoparticles (NANs) need to cross several extra- and intracellular barriers to reach the cytoplasm or nucleus of the target cells. In the last decade several gro...
- Dendritic multishell architectures for drug and dye transport
[作者:Quadir, MA; Radowski, MR; Kratz, F; Licha, K; Hauff, P; Haag, R,期刊:Journal of controlled release, 页码:289-294 , 文章类型: Article,,卷期:2008年132-3]
- Here we present the efficiency and versatility of newly developed core-multishell nanoparticles (CMS NPs), to encapsulate and transport the antitumor drugs doxorubicin hydrochloride (Dox), methotrexate (Mtx) and sodium i...
- Conjugates of doxorubicin with graft HPMA copolymers for passive tumor targeting
[作者:Etrych, T; Chytil, P; Mrkvan, T; Sirova, M; Rihova, B; Ulbrich, K,期刊:Journal of controlled release, 页码:184-192 , 文章类型: Article,,卷期:2008年132-3]
- Synthesis, physicochemical behavior, tumor accumulation and preliminary anticancer activity of a new biodegradable graft copolymer-doxorubicin (DOX) conjugates designed for passive tumor targeting were investigated. In t...
- Tumor-targeted HPMA copolymer-(RGDfK)-(CHX-A ''-DTPA) conjugates show increased kidney accumulation
[作者:Borgman, MP; Coleman, T; Kolhatkar, RB; Geyser-Stoops, S; Line, BR; Ghandehari, H,期刊:Journal of controlled release, 页码:193-199 , 文章类型: Article,,卷期:2008年132-3]
- N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer-RGDfK conjugates targeting the alpha(v)beta(3) integrin have shown increased accumulation in solid tumors and promise for selective delivery of radiotherapeutics to sit...
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