- Drug Development: Portals of Discovery
[作者:Bates, SE; Amiri-Kordestani, L; Giaccone, G,期刊:Clinical Cancer Research, 页码:23-32 , 文章类型: Article,,卷期:2012年18-1]
- A British humorist said, "There is much to be said for failure. It is much more interesting than success." This CCR Focus section is aimed at identifying lessons to be learned from difficulties encountered in recent year...
- Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy
[作者:Kemp, CD; Rao, M; Xi, SC; Inchauste, S; Mani, H; Fetsch, P; Filie, A; Zhang, M; Hong, JA; Walker, RL; Zhu, YLJ; Ripley, RT; Mathur, A; Liu, F; Yang, MC; Meltzer, PA; Marquez, VE; De Rienzo, A; Bueno, R; Schrump, DS,期刊:Clinical Cancer Research, 页码:77-90 , 文章类型: Article,,卷期:2012年18-1]
- Purpose: Polycomb group (PcG) proteins are critical epigenetic mediators of stem cell pluripotency, which have been implicated in the pathogenesis of human cancers. This study was undertaken to examine the frequency and ...
- Eph-B2/Ephrin-B2 Interaction Plays a Major Role in the Adhesion and Proliferation of Waldenstrom's Macroglobulinemia
[作者:Azab, F; Azab, AK; Maiso, P; Calimeri, T; Flores, L; Liu, Y; Quang, P; Roccaro, AM; Sacco, A; Ngo, HT; Zhang, Y; Morgan, BL; Carrasco, RD; Ghobrial, IM,期刊:Clinical Cancer Research, 页码:91-104 , 文章类型: Article,,卷期:2012年18-1]
- Purpose: The ephrin receptors (Eph) are found in a wide range of cancers and correlate with metastasis. In this study, we characterized the role of Eph-B2 receptor in the interaction of Waldenstrom's macroglobulinemia (W...
- Costimulatory Protein 4IgB7H3 Drives the Malignant Phenotype of Glioblastoma by Mediating Immune Escape and Invasiveness
[作者:Lemke, D; Pfenning, PN; Sahm, F; Klein, AC; Kempf, T; Warnken, U; Schnolzer, M; Tudoran, R; Weller, M; Platten, M; Wick, W,期刊:Clinical Cancer Research, 页码:105-117 , 文章类型: Article,,卷期:2012年18-1]
- Purpose: Recent work points out a role of B7H3, a member of the B7-family of costimulatory proteins, in conveying immunosuppression and enforced invasiveness in a variety of tumor entities. Glioblastoma is armed with eff...
- Cytoplasmic Estrogen Receptor in Breast Cancer
[作者:Welsh, AW; Lannin, DR; Young, GS; Sherman, ME; Figueroa, JD; Henry, NL; Ryden, L; Kim, C; Love, RR; Schiff, R; Rimm, DL,期刊:Clinical Cancer Research, 页码:118-126 , 文章类型: Article,,卷期:2012年18-1]
- Purpose: In addition to genomic signaling, it is accepted that estrogen receptor-alpha (ER alpha) has nonnuclear signaling functions, which correlate with tamoxifen resistance in preclinical models. However, evidence for...
- STAT5A-Mediated SOCS2 Expression Regulates Jak2 and STAT3 Activity Following c-Src Inhibition in Head and Neck Squamous Carcinoma
[作者:Sen, B; Peng, SH; Woods, DM; Wistuba, I; Bell, D; El-Naggar, AK; Lai, SY; Johnson, FM,期刊:Clinical Cancer Research, 页码:127-139 , 文章类型: Article,,卷期:2012年18-1]
- Purpose: The inhibition of c-Src results in a striking reduction in cancer cell invasion, but the effect on cell survival is modest. Defining mechanisms that limit apoptosis following c-Src inhibition could result in an ...
- Phenylarsine Oxide Induces Apoptosis in Bax- and Bak-Deficient Cells through Upregulation of Bim
[作者:Ni, BY; Ma, Q; Li, BW; Zhao, LX; Liu, Y; Zhu, YS; Chen, Q,期刊:Clinical Cancer Research, 页码:140-151 , 文章类型: Article,,卷期:2012年18-1]
- Purpose: Bax and Bak are regarded as key mediators for cytochrome c (Cyt c) release and apoptosis. Loss of Bax or Bak is often reported in human cancers and renders resistance of these cancerous cells to chemotherapy. He...
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