- Liposome based systems for systemic siRNA delivery: Stability in blood sets the requirements for optimal carrier design
[作者：Buyens, K; De Smedt, SC; Braeckmans, K; Demeester, J; Peeters, L; van Grunsven, LA; du Jeu, XD; Sawant, R; Torchilin, V; Farkasova, K; Ogris, M; Sanders, NN,期刊：Journal of controlled release, 页码：362-370 , 文章类型： Review，,卷期：2012年158-3]
- siRNA therapeutics are currently regarded as promising candidates to make a leap forward in the search for treatments of various hard to cure diseases. In order to exploit the full potential of siRNA based therapeutics, ...
- Uptake mechanisms of non-viral gene delivery
[作者：Xiang, SN; Tong, HJ; Shi, Q; Fernandes, JC; Jin, T; Dai, KR; Zhang, XL,期刊：Journal of controlled release, 页码：371-378 , 文章类型： Review，,卷期：2012年158-3]
- Non-viral gene delivery is currently a hot subject for its relative safety and simplicity of use; however, it is still far from being ideal enough to be clinically used for its comparatively lower efficiency than viral g...
- An injectable depot system for sustained intraperitoneal chemotherapy of ovarian cancer results in favorable drug distribution at the whole body, peritoneal and intratumoral levels
[作者：Zahedi, P; Stewart, J; De Souza, R; Piquette-Miller, M; Allen, C,期刊：Journal of controlled release, 页码：379-385 , 文章类型： Article，,卷期：2012年158-3]
- The current study characterizes the impact of docetaxel (DTX) distribution on efficacy following sustained intraperitoneal (IP) chemotherapy in murine models of ovarian cancer. A polymer-lipid biodegradable depot (PoLige...
- Controlled release of a highly hydrophilic API from lipid microspheres obtained by prilling: Analysis of drug and water diffusion processes with X-ray-based methods
[作者：Pivette, P; Faivre, V; Mancini, L; Gueutin, C; Daste, G; Ollivon, M; Lesieur, S,期刊：Journal of controlled release, 页码：393-402 , 文章类型： Article，,卷期：2012年158-3]
- This study deals with the development of an oral controlled-release dosage form of a highly water-soluble antiepileptic drug. In this respect, drug-loaded spheroid particles close to 380 mu m in diameter and composed of ...
- Monitoring the transport of polymeric micelles across MDCK cell monolayer and exploring related mechanisms
[作者：Zhao, SS; Dai, WB; He, B; Wang, JC; He, ZG; Zhang, X; Zhang, Q,期刊：Journal of controlled release, 页码：413-423 , 文章类型： Article，,卷期：2012年158-3]
- Although some formulations based on nanotechnology are already available, the transport of nanoscale particles including polymeric micelles (PMs) across epithelial cellmonolayerwas barely studied. To prove the transport ...
- Magnetic field-controlled gene expression in encapsulated cells
[作者：Ortner, V; Kaspar, C; Halter, C; Tollner, L; Mykhaylyk, O; Walzer, J; Gunzburg, WH; Dangerfield, JA; Hohenadl, C; Czerny, T,期刊：Journal of controlled release, 页码：424-432 , 文章类型： Article，,卷期：2012年158-3]
- Cell and gene therapies have an enormous range of potential applications, but as for most other therapies, dosing is a critical issue, which makes regulated gene expression a prerequisite for advanced strategies. Several...
- High-content screening of peptide-based non-viral gene delivery systems
[作者：de Raad, M; Teunissen, EA; Lelieveld, D; Egan, DA; Mastrobattista, E,期刊：Journal of controlled release, 页码：433-442 , 文章类型： Article，,卷期：2012年158-3]
- High-content screening (HCS) uses high-capacity automated fluorescence imaging for the quantitative analysis of single cells and cell populations. Here, we developed an HCS assay for rapid screening of non-viral gene del...
- Optimization of 100 mu m alginate-poly-L-lysine-alginate capsules for intravitreous administration
[作者：Santos, E; Orive, G; Calvo, A; Catena, R; Fernandez-Robredo, P; Layana, AG; Hernandez, RM; Pedraz, JL,期刊：Journal of controlled release, 页码：443-450 , 文章类型： Article，,卷期：2012年158-3]
- The field of cell microencapsulation is advancing rapidly. Particle size plays a critical role in terms of biocompatibility and limits decisively its applicability. Producing reduced size microcapsules involves broadenin...
- Linearized oncolytic adenoviral plasmid DNA delivered by bioreducible polymers
[作者：Kim, J; Kim, PH; Nam, HY; Lee, JS; Yun, CO; Kim, SW,期刊：Journal of controlled release, 页码：451-460 , 文章类型： Article，,卷期：2012年158-3]
- As an effort to overcome limits of adenovirus (Ad) as a systemic delivery vector for cancer therapy, we developed a novel system using oncolytic Ad plasmid DNA with two bioreducible polymers: arginine-grafted bioreducibl...
- Paromomycin and neomycin B derived cationic lipids: Synthesis and transfection studies
[作者：Mevel, M; Sainlos, M; Chatin, B; Oudrhiri, N; Hauchecorne, M; Lambert, O; Vigneron, JP; Lehn, P; Pitard, B; Lehn, JM,期刊：Journal of controlled release, 页码：461-469 , 文章类型： Article，,卷期：2012年158-3]
- Cationic lipid-based nonviral gene delivery is an attractive approach for therapeutic gene transfer. Basically, gene transfection can be achieved by using synthetic vectors that compact DNA, forming cationic lipoplexeswh...
- Bone metastasis targeting: A novel approach to reach bone using Zoledronate anchored PLGA nanoparticle as carrier system loaded with Docetaxel
[作者：Chaudhari, KR; Kumar, A; Khandelwal, VKM; Ukawala, M; Manjappa, AS; Mishra, AK; Monkkonen, J; Murthy, RSR,期刊：Journal of controlled release, 页码：470-478 , 文章类型： Article，,卷期：2012年158-3]
- In spite of good research in drug delivery, bone targeting remains largely unexplored. Even some of the bone diseases are seldom cured just because of poor distribution of drug at the bone site. Zoledronate (ZOL) having ...
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