Expert opinion on investigational drugs————————个性化文献订阅—

Therapeutic potential of the original incretin hormone glucose-dependent insulinotropic polypeptide: diabetes, obesity, osteoporosis and Alzheimer's disease?
[作者：Irwin, N; Gault, V; Flatt, PR,期刊：Expert opinion on investigational drugs, 页码：1039-1048 , 文章类型： Review，,卷期：2010年19-9]
Importance to the field: Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone that potentiates nutrient-induced insulin release. To date, the physiological importance of GIP has received much less at...

The clinical development of histone deacetylase inhibitors as targeted anticancer drugs
[作者：Marks, PA,期刊：Expert opinion on investigational drugs, 页码：1049-1066 , 文章类型： Review，,卷期：2010年19-9]
Importance of the field: Histone deacetylase (HDAC) inhibitors are being developed as a new, targeted class of anticancer drugs. Area covered in this review: This review focuses on the mechanisms of action of the HDAC in...

Comparison between the antiproteinuric effects of the calcium channel blockers benidipine and cilnidipine in combination with angiotensin receptor blockers in hypertensive patients with chronic kidney disease
[作者：Abe, M; Okada, K; Maruyama, N; Matsumoto, S; Maruyama, T; Fujita, T; Matsumoto, K; Soma, M,期刊：Expert opinion on investigational drugs, 页码：1027-1037 , 文章类型： Article，,卷期：2010年19-9]
Aims: Benidipine, an L-/T-type calcium channel blocker, dilates renal efferent and afferent arterioles and reduces glomerular pressure; therefore, it may exert renoprotective effects. We conducted an open-labeled randomi...

New small molecules for the treatment of Parkinson's disease
[作者：Muller, T,期刊：Expert opinion on investigational drugs, 页码：1077-1086 , 文章类型： Review，,卷期：2010年19-9]
Importance of the field: Parkinson's disease (PD) is characterized by a slowly ongoing neuronal death, which affects neurotransmitter metabolism and causes a wide variety of motor and non-motor features. Until now, thera...

Novel integrase inhibitors for HIV
[作者：Prada, N; Markowitz, M,期刊：Expert opinion on investigational drugs, 页码：1087-1098 , 文章类型： Review，,卷期：2010年19-9]
Importance of the field: Integrase inhibitors are the newest class of antiretroviral agents developed to treat HIV-1 infection. Raltegravir (RAL), the only integrase inhibitor (INI) currently approved for the treatment o...

11 beta-Hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes
[作者：Morgan, SA; Tomlinson, JW,期刊：Expert opinion on investigational drugs, 页码：1067-1076 , 文章类型： Review，,卷期：2010年19-9]
Importance of the field: The prevalence of obesity and type 2 diabetes is rising and reaching pandemic proportions. For this reason, identification of novel therapeutic targets is urgently needed. Areas covered in this r...

Lacosamide for pain
[作者：McCleane, G,期刊：Expert opinion on investigational drugs, 页码：1129-1134 , 文章类型： Editorial Material，,卷期：2010年19-9]
Importance of the field: Neuropathic pain remains a condition that is difficult to treat and with which therapeutic failure is not uncommon. The need for new and effective drugs to treat neuropathic pain remains strong. ...

Novel investigational drugs for basal cell carcinoma
[作者：So, PL; Tang, JY; Epstein, EH,期刊：Expert opinion on investigational drugs, 页码：1099-1112 , 文章类型： Review，,卷期：2010年19-9]
Importance of the field: In the United States, the annual incidence of basal cell carcinoma (BCC) is close to 1 million. Ultraviolet radiation exposure is the main risk factor; however, the availability of ever more pote...

Investigational histone deacetylase inhibitors for non-Hodgkin lymphomas
[作者：Watanabe, T,期刊：Expert opinion on investigational drugs, 页码：1113-1127 , 文章类型： Review，,卷期：2010年19-9]
Importance of the field: Histone deacetylase inhibitors (HDIs) have been shown effective as single agents for cutaneous T-cell lymphomas, peripheral T-cell lymphomas, and B-cell lymphomas, such as follicular lymphoma and...