- Novel therapeutic strategies targeting vascular endothelium in essential hypertension
[作者:Tousoulis, D; Papageorgiou, N; Androulakis, E; Paroutoglou, K; Stefanadis, C,期刊:Expert opinion on investigational drugs, 页码:1395-1412 , 文章类型: Review,,卷期:2010年19-11]
- Importance of the field: Several studies have demonstrated the high prevalence of hypertension and the crucial role of the association between endothelial function and hypertension. Thus, in depth investigation of the pa...
- Avanafil, a new rapid-onset phosphodiesterase 5 inhibitor for the treatment of erectile dysfunction
[作者:Limin, M; Johnsen, N; Hellstrom, WJG,期刊:Expert opinion on investigational drugs, 页码:1427-1437 , 文章类型: Editorial Material,,卷期:2010年19-11]
- Importance of the field: Erectile dysfunction (ED) is a common sexual problem, affecting up to half of men over 50 years of age. Phosphodiesterase type 5 (PDE5) inhibitors (sildenafil, tadalafil and vardenafil) are curre...
- PLX4032: does it keep its promise for metastatic melanoma treatment?
[作者:Livingstone, E; Zimmer, L; Piel, S; Schadendorf, D,期刊:Expert opinion on investigational drugs, 页码:1439-1449 , 文章类型: Editorial Material,,卷期:2010年19-11]
- Importance of the field: Activating mutations in the BRAF kinase gene have been identified in 50% of all melanomas. PLX4032, a selective and potent inhibitor of BRAF V600E mutant tumor cells, has shown inhibition of tumo...
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