- Therapeutic potential of matrix metalloprotease inhibitors in neuropathic pain
[作者:Dev, R; Srivastava, PK; Iyer, JP; Dastidar, SG; Ray, A,期刊:Expert opinion on investigational drugs, 页码:455-468 , 文章类型: Review,,卷期:2010年19-4]
- Importance of the field: Millions of people suffer from neuropathic pain (NP), but the treatment is empirical and results in transient relief in only a few patients. This is primarily because of the poor understanding of...
- Discovery and development of selective PPAR-gamma modulators (SPPAR-gamma Ms) as safe and effective antidiabetic agents
[作者:Doshi, LS; Brahma, MK; Bahirat, UA; Dixit, AV; Nemmani, KVS,期刊:Expert opinion on investigational drugs, 页码:489-512 , 文章类型: Review,,卷期:2010年19-4]
- Importance of the field: PPAR-gamma full agonists (pioglitazone and rosiglitazone) are the mainstay drugs for the treatment of type 2 diabetes; however, mechanism-based side effects have limited their full therapeutic po...
- Therapeutic use of coenzyme Q(10) and coenzyme Q(10)-related compounds and formulations
[作者:Villalba, JM; Parrado, C; Santos-Gonzalez, M; Alcain, FJ,期刊:Expert opinion on investigational drugs, 页码:535-554 , 文章类型: Review,,卷期:2010年19-4]
- Importance of the field: Coenzyme Q(10) (CoQ(10)) is found in blood and in all organs. CoQ(10) deficiencies are due to autosomal recessive mutations, ageing-related oxidative stress and carcinogenesis processes, and also...
- AICA-riboside (acadesine), an activator of AMP-activated protein kinase with potential for application in hematologic malignancies
[作者:Van den Neste, E; Van den Berghe, G; Bontemps, F,期刊:Expert opinion on investigational drugs, 页码:571-578 , 文章类型: Article,,卷期:2010年19-4]
- Importance of the field: Despite considerable advances, B-cell chronic lymphocytic leukemia (CLL) is incurable with standard approaches. Thus, there remains a need for new therapies, particularly for patients who develop...
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