- Modulation of monoamine transporters by common biogenic amines via trace amine-associated receptor 1 and monoamine autoreceptors in human embryonic kidney 293 cells and brain synaptosomes
[作者:Xie, ZH; Westmoreland, SV; Miller, GM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:629-640 , 文章类型: Article,,卷期:2008年325-2]
In brain monoaminergic systems, common biogenic amines, including dopamine, norepinephrine, and serotonin, serve as neurotransmitters. Monoamine autoreceptors provide feedback regulation in neurotransmitter release, a...
- Delivery of acid sphingomyelinase in normal and Niemann-Pick disease mice using intercellular adhesion molecule-1-targeted polymer nanocarriers
[作者:Garnacho, C; Dhami, R; Simone, E; Dziubla, T; Leferovich, J; Schuchman, EH; Muzykantov, V; Muro, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:400-408 , 文章类型: Article,,卷期:2008年325-2]
Type B Niemann-Pick disease ( NPD) is a multiorgan system disorder caused by a genetic deficiency of acid sphingomyelinase ( ASM), for which lung is an important and challenging therapeutic target. In this study, we d...
- Tetrathiomolybdate protects against bile duct ligation-induced cholestatic liver injury and fibrosis
[作者:Song, M; Song, ZY; Barve, S; Zhang, JW; Chen, T; Liu, M; Arteel, GE; Brewer, GJ; McClain, CJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:409-416 , 文章类型: Article,,卷期:2008年325-2]
Tetrathiomolybdate ( TM), a potent copper-chelating drug, was initially developed for the treatment of Wilson's disease. Our working hypothesis is that the fibrotic pathway is copper-dependent. Because biliary excreti...
- Modeling the binding and function of metabotropic glutamate receptors
[作者:Rovira, X; Roche, D; Serra, J; Kniazeff, J; Pin, JP; Giraldo, J,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:443-456 , 文章类型: Article,,卷期:2008年325-2]
A mathematical model for the binding and function of metabotropic glutamate receptors was developed, with the aim to gain new insights into the functioning of these complex receptors. These receptors are homodimers, a...
- Lorcaserin, a novel selective human 5-Hydroxytryptamine(2C) agonist: In vitro and in vivo pharmacological characterization
[作者:Thomsen, WJ; Grottick, AJ; Menzaghi, F; Reyes-Saldana, H; Espitia, S; Yuskin, D; Whelan, K; Martin, M; Morgan, M; Chen, W; Al-Shamma, H; Smith, B; Chalmers, D; Behan, D,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:577-587 , 文章类型: Article,,卷期:2008年325-2]
5-Hydroxytryptamine (5-HT)(2C) receptor agonists hold promise for the treatment of obesity. In this study, we describe the in vitro and in vivo characteristics of lorcaserin [(1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-...
- Drug-induced alterations to gene and protein expression in intestinal epithelial cell 6 cells suggest a role for calpains in the gastrointestinal toxicity of nonsteroidal anti-inflammatory agents
[作者:Raveendran, NN; Silver, K; Freeman, LC; Narvaez, D; Weng, K; Ganta, S; Lillich, JD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:389-399 , 文章类型: Article,,卷期:2008年325-2]
Nonsteroidal anti-inflammatory drugs ( NSAIDs) are used extensively as therapeutic agents, despite their well documented gastrointestinal ( GI) toxicity. At this time, the mechanisms responsible for NSAID-associated G...
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