- N,N '-alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: Inhibition of nicotine-evoked dopamine release and hyperactivity
[作者:Dwoskin, LP; Wooters, TE; Sumithran, SP; Siripurapu, KB; Joyce, BM; Lockman, PR; Manda, VK; Ayers, JT; Zhang, ZF; Deaciuc, AG; McIntosh, JM; Crooks, PA; Bardo, MT,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:563-576 , 文章类型: Article,,卷期:2008年326-2]
The current study evaluated a new series of N,N'-alkane-diylbis-3-picolinium (bAPi) analogs with C-6-C-12 methylene linkers as nicotinic acetylcholine receptor (nAChR) antagonists, for nicotine-evoked [H-3] dopamine (...
- The endogenous cannabinoid system modulates nicotine reward and dependence
[作者:Merritt, LL; Martin, BR; Walters, C; Lichtman, AH; Damaj, MI,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:483-492 , 文章类型: Article,,卷期:2008年326-2]
A growing body of evidence suggests that the endogenous cannabinoid system modulates the addictive properties of nicotine, the main component of tobacco that produces rewarding effects. In our study, complementary tra...
- Effects of novel vasopressin receptor antagonists on renal function and cardiac hypertrophy in rats with experimental congestive heart failure
[作者:Bishara, B; Shiekh, H; Karram, T; Rubinstein, I; Azzam, ZS; Abu-Saleh, N; Nitecki, S; Winaver, J; Hoffman, A; Abassi, ZA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:414-422 , 文章类型: Article,,卷期:2008年326-2]
Arginine vasopressin (AVP) plays an important role in renal hemodynamic alterations, water retention, and cardiac remodeling in congestive heart failure (CHF). The present study evaluated the acute and chronic effects...
- Point mutation of the proteasome beta 5 subunit gene is an important mechanism of bortezomib resistance in bortezomib-selected variants of Jurkat T cell lymphoblastic lymphoma/leukemia line
[作者:Lu, SQ; Yang, JM; Song, XM; Gong, SL; Zhou, H; Guo, LP; Song, NX; Bao, XC; Chen, PP; Wang, JM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:423-431 , 文章类型: Article,,卷期:2008年326-2]
To study the mechanism of acquired resistance to bortezomib, a new antitumor drug that is the first therapeutic proteasome inhibitor, we established a series of bortezomib-resistant T lymphoblastic lymphoma/leukemia c...
- Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for proteinase-activated receptor 2: Binding and visualization
[作者:Hollenberg, MD; Renaux, B; Hyun, E; Houle, S; Vergnolle, N; Saifeddine, M; Ramachandran, R,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:453-462 , 文章类型: Article,,卷期:2008年326-2]
The proteinase-activated receptor-2 (PAR(2))-activating peptide with an N-terminal furoyl group modification, 2-furoyl-LIGRLO-NH2 (2fLI), was derivatized via its free ornithine amino group to yield [H-3] propionyl-2fL...
- 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated impairment of B cell differentiation involves dysregulation of paired box 5 (Pax5) isoform, Pax5a
[作者:Schneider, D; Manzan, MA; Crawford, RB; Chen, WM; Kaminski, NE,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:463-474 , 文章类型: Article,,卷期:2008年326-2]
The persistent environmental contaminant and immunotoxicant, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), markedly suppresses humoral immune responses. We recently reported impaired down-regulation of paired box 5 (Pax...
- Reversal of oxidative stress-induced anxiety by inhibition of phosphodiesterase-2 in mice
[作者:Masood, A; Nadeem, A; Mustafa, SJ; O'Donnell, JM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:369-379 , 文章类型: Article,,卷期:2008年326-2]
The pathogenesis of several neuropsychiatric disorders, including anxiety and depression, has been linked to oxidative stress, in part via alterations in cyclic nucleotide signaling. Phosphodiesterase-2 (PDE2), which ...
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