- Small-Molecule Induction of Neural Crest-like Cells Derived from Human Neural Progenitors
[作者:Hotta, R; Pepdjonovic, L; Anderson, RB; Zhang, DC; Bergner, AJ; Leung, J; Pebay, A; Young, HM; Newgreen, DF; Dottori, M,期刊:Stem Cells, 页码:2896-2905 , 文章类型: Article,,卷期:2009年27-12]
- Neural crest (NC) cells are stem cells that are specified within the embryonic neuroectodermal epithelium and migrate to stereotyped peripheral sites for differentiation into many cell types. Several neurocristopathies i...
- Developmental Regulation of Human Embryonic Stem Cell-Derived Neurons by Calcium Entry Via Transient Receptor Potential Channels
[作者:Weick, JP; Johnson, MA; Zhang, SC,期刊:Stem Cells, 页码:2906-2916 , 文章类型: Article,,卷期:2009年27-12]
- Spontaneous calcium (Ca2+) transients in the developing nervous system can affect proliferation, migration, neuronal subtype specification, and neurite outgrowth. Here, we show that telencephalic human neuroepithelia (hN...
- Wnt/beta-Catenin Signaling Blockade Promotes Neuronal Induction and Dopaminergic Differentiation in Embryonic Stem Cells
[作者:Cajanek, L; Ribeiro, D; Liste, I; Parish, CL; Bryja, V; Arenas, E,期刊:Stem Cells, 页码:2917-2927 , 文章类型: Article,,卷期:2009年27-12]
- Embryonic stem cells (ESCs) represent not only a promising source of cells for cell replacement therapy, but also a tool to study the molecular mechanisms underlying cellular signaling and dopaminergic (DA) neuron develo...
- CD15, CD24, and CD29 Define a Surface Biomarker Code for Neural Lineage Differentiation of Stem Cells
[作者:Pruszak, J; Ludwig, W; Blak, A; Alavian, K; Isacson, O,期刊:Stem Cells, 页码:2928-2940 , 文章类型: Article,,卷期:2009年27-12]
- Identification and use of cell surface cluster of differentiation (CD) biomarkers have enabled much scientific and clinical progress. We identify a CD surface antigen code for the neural lineage based on combinatorial fl...
- CD133 Expression Defines a Tumor Initiating Cell Population in Primary Human Ovarian Cancer
[作者:Curley, MD; Therrien, VA; Cummings, CL; Sergent, PA; Koulouris, CR; Friel, AM; Roberts, DJ; Seiden, MV; Scadden, DT; Rueda, BR; Foster, R,期刊:Stem Cells, 页码:2875-2883 , 文章类型: Article,,卷期:2009年27-12]
- Evidence is accumulating that solid tumors contain a rare phenotypically distinct population of cells, termed cancer stem cells (CSC), which give rise to and maintain the bulk of the tumor. These CSC are thought to be re...
- Transcriptional Activation by the Mixl1 Homeodomain Protein in Differentiating Mouse Embryonic Stem Cells
[作者:Zhang, HL; Fraser, ST; Papazoglu, C; Hoatlin, ME; Baron, MH,期刊:Stem Cells, 页码:2884-2895 , 文章类型: Article,,卷期:2009年27-12]
- Members of the Mix/Bix family of paired class homeobox genes play important roles in the development of vertebrate mesoderm and endoderm. The single Mix/Bix family member identified in the mouse, Mix-like 1 (Mixl1), is r...
- Generation of Parthenogenetic Induced Pluripotent Stem Cells from Parthenogenetic Neural Stem Cells
[作者:Do, JT; Joo, JY; Han, DW; Arauzo-Bravo, MJ; Kim, MJ; Greber, B; Zaehres, H; Sobek-Klocke, I; Chung, HM; Scholer, HR,期刊:Stem Cells, 页码:2962-2968 , 文章类型: Article,,卷期:2009年27-12]
- Somatic cells can achieve a pluripotent cell state in a process called pluripotential reprogramming. Multipotent stem cells can differentiate into cells of only one lineage, but pluripotent stem cells can give rise to ce...
- Klf4 Interacts Directly with Oct4 and Sox2 to Promote Reprogramming
[作者:Wei, Z; Yang, Y; Zhang, PL; Andrianakos, R; Hasegawa, K; Lyu, JM; Chen, X; Bai, G; Liu, CM; Pera, M; Lu, WG,期刊:Stem Cells, 页码:2969-2978 , 文章类型: Article,,卷期:2009年27-12]
- Somatic cells can be reprogrammed to induced pluripotent stem (iPS) cells by ectopic expression of specific sets of transcription factors. Oct4, Sox2, and Klf4, factors that share many target genes in embryonic stem (ES)...
- Smarcc1/Baf155 Couples Self-Renewal Gene Repression with Changes in Chromatin Structure in Mouse Embryonic Stem Cells
[作者:Schaniel, C; Ang, YS; Ratnakumar, K; Cormier, C; James, T; Bernstein, E; Lemischka, IR; Paddison, PJ,期刊:Stem Cells, 页码:2979-2991 , 文章类型: Article,,卷期:2009年27-12]
- Little is known about the molecular mechanism(s) governing differentiation decisions in embryonic stem cells (ESCs). To identify factors critical for ESC lineage formation, we carried out a functional genetic screen for ...
- Generation of Human-Induced Pluripotent Stem Cells in the Absence of Exogenous Sox2
[作者:Li, WL; Zhou, HY; Abujarour, R; Zhu, SY; Joo, JY; Lin, TX; Hao, EG; Scholer, HR; Hayek, A; Ding, S,期刊:Stem Cells, 页码:2992-3000 , 文章类型: Article,,卷期:2009年27-12]
- Induced pluripotent stem cell technology has attracted enormous interest for potential application in regenerative medicine. Here, we report that a specific glycogen synthase kinase 3 (GSK-3) inhibitor, CHIR99021, can in...
- RNA Polymerase II Associated Factor 1/PD2 Maintains Self-Renewal by Its Interaction with Oct3/4 in Mouse Embryonic Stem Cells
[作者:Ponnusamy, MP; Deb, S; Dey, P; Chakraborty, S; Rachagani, S; Senapati, S; Batra, SK,期刊:Stem Cells, 页码:3001-3011 , 文章类型: Article,,卷期:2009年27-12]
- Embryonic stem cells (ESCs) maintain self-renewal while ensuring a rapid response to differentiation signals, but the exact mechanism of this process remains unknown. PD2 is the human homolog of the RNA polymerase II-ass...
- Hsp20-Engineered Mesenchymal Stem Cells Are Resistant to Oxidative Stress via Enhanced Activation of Akt and Increased Secretion of Growth Factors
[作者:Wang, XH; Zhao, TM; Huang, W; Wang, T; Qian, J; Xu, MF; Kranias, EG; Wang, YG; Fan, GC,期刊:Stem Cells, 页码:3021-3031 , 文章类型: Article,,卷期:2009年27-12]
- Although heat-shock preconditioning has been shown to promote cell survival under oxidative stress, the nature of heat-shock response from different cells is variable and complex. Therefore, it remains unclear whether me...
- Lineage Enforcement by Inductive Mesenchyme on Adult Epithelial Stem Cells across Developmental Germ Layers
[作者:Taylor, RA; Wang, H; Wilkinson, SE; Richards, MG; Britt, KL; Vaillant, F; Lindeman, GJ; Visvader, JE; Cunha, GR; John, JS; Risbridger, GP,期刊:Stem Cells, 页码:3032-3042 , 文章类型: Article,,卷期:2009年27-12]
- During development, cell differentiation is accompanied by the progressive loss of pluripotent gene expression and developmental potential, although de-differentiation in specialized cells can be induced by reprogramming...
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