- Dual Function of ERR alpha in Breast Cancer and Bone Metastasis Formation: Implication of VEGF and Osteoprotegerin
[作者:Fradet, A; Sorel, H; Bouazza, L; Goehrig, D; Depalle, B; Bellahcene, A; Castronovo, V; Follet, H; Descotes, F; Aubin, JE; Clezardin, P; Bonnelye, E,期刊:Cancer research, 页码:5728-5738 , 文章类型: Article,,卷期:2011年71-17]
- Bone metastasis is a complication occurring in up to 70% of advanced breast cancer patients. The estrogen receptor-related receptor alpha (ERR alpha) has been implicated in breast cancer and bone development, prompting u...
- Estrogen-Dependent Gene Transcription in Human Breast Cancer Cells Relies upon Proteasome-Dependent Monoubiquitination of Histone H2B
[作者:Prenzel, T; Begus-Nahrmann, Y; Kramer, F; Hennion, M; Hsu, C; Gorsler, T; Hintermair, C; Eick, D; Kremmer, E; Simons, M; Beissbarth, T; Johnsen, SA,期刊:Cancer research, 页码:5739-5753 , 文章类型: Article,,卷期:2011年71-17]
- The estrogen receptor-alpha (ER alpha) determines the phenotype of breast cancers where it serves as a positive prognostic indicator. ER alpha is a well-established target for breast cancer therapy, but strategies to tar...
- Prognostic and Predictive Impact of Intra- and Peritumoral Immune Infiltrates
[作者:Fridman, WH; Galon, J; Pages, F; Tartour, E; Sautes-Fridman, C; Kroemer, G,期刊:Cancer research, 页码:5601-5605 , 文章类型: Review,,卷期:2011年71-17]
- Leukocyte infiltrates into or around tumor cell nests are found in the context of protumorigenic inflammation and anticancer immunosurveillance. Hence, the detailed composition, density, architecture, and function of leu...
- TGF-beta/SMAD/GLI2 Signaling Axis in Cancer Progression and Metastasis
[作者:Javelaud, D; Alexaki, VI; Dennler, S; Mohammad, KS; Guise, TA; Mauviel, A,期刊:Cancer research, 页码:5606-5610 , 文章类型: Review,,卷期:2011年71-17]
- The Hedgehog (HH) and TGF-beta signaling pathways represent essential regulators of cell proliferation and differentiation during embryogenesis. Pathway deregulation is a characteristic of various cancers. Recently, evid...
- Nano in Cancer: Linking Chemistry, Biology, and Clinical Applications In Vivo
[作者:Dothager, RS; Piwnica-Worms, D,期刊:Cancer research, 页码:5611-5615 , 文章类型: Article,,卷期:2011年71-17]
- Development of nanoparticle agents for cancer therapeutics and diagnostics is steadily progressing and was the subject of the inaugural conference entitled, "Nano in Cancer," held during January 12-15, 2011, in Miami, FL...
- The First AACR Special Conference on Stem Cells, Development, and Cancer: Some of These Cells Are Not Like the Others
[作者:Kent, DG; Lin, JC; Aubert, G,期刊:Cancer research, 页码:5616-5620 , 文章类型: Article,,卷期:2011年71-17]
- The American Association for Cancer Research (AACR) held an exciting conference on Stem Cells, Development, and Cancer in Vancouver, British Columbia, Canada (March 3-6, 2011). The meeting was cochaired by Geoffrey Wahl,...
- HERC2 Interacts with Claspin and Regulates DNA Origin Firing and Replication Fork Progression
[作者:Izawa, N; Wu, WW; Sato, K; Nishikawa, H; Kato, A; Boku, N; Itoh, F; Ohta, T,期刊:Cancer research, 页码:5621-5625 , 文章类型: Article,,卷期:2011年71-17]
- DNA replication, recombination, and repair are highly interconnected processes the disruption of which must be coordinated in cancer. HERC2, a large HECT protein required for homologous recombination repair, is an E3 ubi...
- Phase I Study of PARP Inhibitor ABT-888 in Combination with Topotecan in Adults with Refractory Solid Tumors and Lymphomas
[作者:Kummar, S; Chen, A; Ji, JP; Zhang, YP; Reid, JM; Ames, M; Jia, L; Weil, M; Speranza, G; Murgo, AJ; Kinders, R; Wang, LH; Parchment, RE; Carter, J; Stotler, H; Rubinstein, L; Hollingshead, M; Melillo, G; Pommier, Y; Bonner, W; Tomaszewski, JE; Doroshow, JH,期刊:Cancer research, 页码:5626-5634 , 文章类型: Article,,卷期:2011年71-17]
- A phase I trial of ABT-888 (veliparib), a PARP inhibitor, in combination with topotecan, a topoisomerase I-targeted agent, was carried out to determine maximum tolerated dose (MTD), safety, pharmacokinetics, and pharmaco...
- microRNA-Associated Progression Pathways and Potential Therapeutic Targets Identified by Integrated mRNA and microRNA Expression Profiling in Breast Cancer
[作者:Buffa, FM; Camps, C; Winchester, L; Snell, CE; Gee, HE; Sheldon, H; Taylor, M; Harris, AL; Ragoussis, J,期刊:Cancer research, 页码:5635-5645 , 文章类型: Article,,卷期:2011年71-17]
- microRNA expression profiling plays an emerging role in cancer classification and identification of therapeutic strategies. In this study, we have evaluated the benefits of a joint microRNA-mRNA analysis in breast cancer...
- Genome-wide Profiling of Chromatin Signatures Reveals Epigenetic Regulation of MicroRNA Genes in Colorectal Cancer
[作者:Suzuki, H; Takatsuka, S; Akashi, H; Yamamoto, E; Nojima, M; Maruyama, R; Kai, M; Yamano, H; Sasaki, Y; Tokino, T; Shinomura, Y; Imai, K; Toyota, M,期刊:Cancer research, 页码:5646-5658 , 文章类型: Article,,卷期:2011年71-17]
- Altered expression of microRNAs (miRNA) occurs commonly in human cancer, but the mechanisms are generally poorly understood. In this study, we examined the contribution of epigenetic mechanisms to miRNA dysregulation in ...
- Small RNA Sequencing and Functional Characterization Reveals MicroRNA-143 Tumor Suppressor Activity in Liposarcoma
[作者:Ugras, S; Brill, E; Jacobsen, A; Hafner, M; Socci, ND; DeCarolis, PL; Khanin, R; O'Connor, R; Mihailovic, A; Taylor, BS; Sheridan, R; Gimble, JM; Viale, A; Crago, A; Antonescu, CR; Sander, C; Tuschl, T; Singer, S,期刊:Cancer research, 页码:5659-5669 , 文章类型: Article,,卷期:2011年71-17]
- Liposarcoma remains the most common mesenchymal cancer, with a mortality rate of 60% among patients with this disease. To address the present lack of therapeutic options, we embarked upon a study of microRNA (miRNA) expr...
- Localization and Density of Immune Cells in the Invasive Margin of Human Colorectal Cancer Liver Metastases Are Prognostic for Response to Chemotherapy
[作者:Halama, N; Michel, S; Kloor, M; Zoernig, I; Benner, A; Spille, A; Pommerencke, T; Doeberitz, MV; Folprecht, G; Luber, B; Feyen, N; Martens, UM; Beckhove, P; Gnjatic, S; Schirmacher, P; Herpel, E; Weitz, J; Grabe, N; Jaeger, D,期刊:Cancer research, 页码:5670-5677 , 文章类型: Article,,卷期:2011年71-17]
- Analysis of tumor-infiltrating lymphocytes (TIL) in primary human colorectal cancer (CRC) by in situ immunohistochemical staining supports the hypothesis that the adaptive immune response influences the course of human C...
- Human Solid Tumors Contain High Endothelial Venules: Association with T- and B-Lymphocyte Infiltration and Favorable Prognosis in Breast Cancer
[作者:Martinet, L; Garrido, I; Filleron, T; Le Guellec, S; Bellard, E; Fournie, JJ; Rochaix, P; Girard, JP,期刊:Cancer research, 页码:5678-5687 , 文章类型: Article,,卷期:2011年71-17]
- The mechanisms governing infiltration of lymphocytes into tumors remain poorly characterized, in spite of the critical impact of these cells on patient prognosis and therapeutic responses. High endothelial venules (HEV) ...
- Targeted Therapeutic Remodeling of the Tumor Microenvironment Improves an HER-2 DNA Vaccine and Prevents Recurrence in a Murine Breast Cancer Model
[作者:Liao, D; Liu, Z; Wrasidlo, WJ; Luo, YP; Nguyen, G; Chen, TM; Xiang, R; Reisfeld, RA,期刊:Cancer research, 页码:5688-5696 , 文章类型: Article,,卷期:2011年71-17]
- The tumor microenvironment (TME) mediates immunosuppression resulting in tumor cell escape from immune surveillance and cancer vaccine failure. Immunosuppression is mediated by the STAT-3 transcription factor, which pote...
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