- MicroRNA Regulation of Cancer Stem Cells
[作者：Liu, C; Tang, DG,期刊：Cancer research, 页码：5950-5954 , 文章类型： Review，,卷期：2011年71-18]
- Cancer stem cells (CSC), or cancer cells with stem cell properties, have been reported in many human tumors and are thought to be responsible for tumor initiation, therapy resistance, progression, relapse, and metastasis...
- Using Tandem Mass Spectrometry in Targeted Mode to Identify Activators of Class IA PI3K in Cancer
[作者：Yang, XM; Turke, AB; Qi, J; Song, Y; Rexer, BN; Miller, TW; Janne, PA; Arteaga, CL; Cantley, LC; Engelman, JA; Asara, JM,期刊：Cancer research, 页码：5965-5975 , 文章类型： Article，,卷期：2011年71-18]
- Phosphatiditylinositide-3-kinase (PI3K) is activated in some cancers by direct mutation, but it is activated more commonly in cancer by mutation of upstream acting receptor tyrosine kinases (TK). At present, there is no ...
- Blocking Hypoxia-Induced Autophagy in Tumors Restores Cytotoxic T-Cell Activity and Promotes Regression
[作者：Noman, MZ; Janji, B; Kaminska, B; Van Moer, K; Pierson, S; Przanowski, P; Buart, S; Berchem, G; Romero, P; Mami-Chouaib, F; Chouaib, S,期刊：Cancer research, 页码：5976-5986 , 文章类型： Article，,卷期：2011年71-18]
- The relationship between hypoxic stress, autophagy, and specific cell-mediated cytotoxicity remains unknown. This study shows that hypoxia-induced resistance of lung tumor to cytolytic T lymphocyte (CTL)-mediated lysis i...
- Mast Cell Targeting Hampers Prostate Adenocarcinoma Development but Promotes the Occurrence of Highly Malignant Neuroendocrine Cancers
[作者：Pittoni, P; Tripodo, C; Piconese, S; Mauri, G; Parenza, M; Rigoni, A; Sangaletti, S; Colombo, MP,期刊：Cancer research, 页码：5987-5997 , 文章类型： Article，,卷期：2011年71-18]
- Mast cells (MC) are c-Kit-expressing cells, best known for their primary involvement in allergic reactions, but recently reappraised as important players in either cancer promotion or inhibition. Here, we assessed the ro...
- Human NK Cells Are Alerted to Induction of p53 in Cancer Cells by Upregulation of the NKG2D Ligands ULBP1 and ULBP2
[作者：Textor, S; Fiegler, N; Arnold, A; Porgador, A; Hofmann, TG; Cerwenka, A,期刊：Cancer research, 页码：5998-6009 , 文章类型： Article，,卷期：2011年71-18]
- Natural killer (NK) cells are immune cells sensing and eliminating foreign, stressed, transformed, and senescent cells through specialized surface receptors, such as NKG2D, that interacts with several virus-or stress-ind...
- Activated Notch1 Induces Lung Adenomas in Mice and Cooperates with Myc in the Generation of Lung Adenocarcinoma
[作者：Allen, TD; Rodriguez, EM; Jones, KD; Bishop, JM,期刊：Cancer research, 页码：6010-6018 , 文章类型： Article，,卷期：2011年71-18]
- Notch1 encodes the canonical member of the mammalian Notch receptor family. Activating lesions frequently affect Notch1 in T-cell acute lymphoblastic leukemia (T-ALL) and, recently, have been found in non-small-cell lung...
- Taxane-Induced Blockade to Nuclear Accumulation of the Androgen Receptor Predicts Clinical Responses in Metastatic Prostate Cancer
[作者：Darshan, MS; Loftus, MS; Thadani-Mulero, M; Levy, BP; Escuin, D; Zhou, XK; Gjyrezi, A; Chanel-Vos, C; Shen, RQ; Tagawa, ST; Bander, NH; Nanus, DM; Giannakakou, P,期刊：Cancer research, 页码：6019-6029 , 文章类型： Article，,卷期：2011年71-18]
- Prostate cancer progression requires active androgen receptor (AR) signaling which occurs following translocation of AR from the cytoplasm to the nucleus. Chemotherapy with taxanes improves survival in patients with cast...
- Biological Roles of the Delta Family Notch Ligand Dll4 in Tumor and Endothelial Cells in Ovarian Cancer
[作者：Hu, W; Lu, CH; Han, HD; Huang, J; Shen, DY; Stone, RL; Nick, AM; Shahzad, MMK; Mora, E; Jennings, NB; Lee, SJ; Roh, JW; Matsuo, K; Nishimura, M; Goodman, BW; Jaffe, RB; Langley, RR; Deavers, MT; Lopez-Berestein, G; Coleman, RL; Sood, AK,期刊：Cancer research, 页码：6030-6039 , 文章类型： Article，,卷期：2011年71-18]
- Emerging evidence suggests that the Notch/Delta-like ligand 4 (Dll4) pathway may offer important new targets for antiangiogenesis approaches. In this study, we investigated the clinical and biological significance of Dll...
- Vitamin D3 Enhances the Apoptotic Response of Epithelial Tumors to Aminolevulinate-Based Photodynamic Therapy
[作者：Anand, S; Wilson, C; Hasan, T; Maytin, EV,期刊：Cancer research, 页码：6040-6050 , 文章类型： Article，,卷期：2011年71-18]
- Photodynamic therapy, mediated by exogenously administered aminolevulinic acid (ALA-PDT), followed by exposure to a laser or broadband light source, is a promising modality for treatment of many types of cancers; however...
- A Novel ALK Secondary Mutation and EGFR Signaling Cause Resistance to ALK Kinase Inhibitors
[作者：Sasaki, T; Koivunen, J; Ogino, A; Yanagita, M; Nikiforow, S; Zheng, W; Lathan, C; Marcoux, JP; Du, JY; Okuda, K; Capelletti, M; Shimamura, T; Ercan, D; Stumpfova, M; Xiao, Y; Weremowicz, S; Butaney, M; Heon, S; Wilner, K; Christensen, JG; Eck, MJ; Wong, KK; Lindeman, N; Gray, NS; Rodig, SJ; Janne, PA,期刊：Cancer research, 页码：6051-6060 , 文章类型： Article，,卷期：2011年71-18]
- Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKI), including crizotinib, are effective treatments in preclinical models and in cancer patients with ALK-translocated cancers. However, their efficacy will u...
- Endothelial Cells Create a Stem Cell Niche in Glioblastoma by Providing NOTCH Ligands That Nurture Self-Renewal of Cancer Stem-Like Cells
[作者：Zhu, TS; Costello, MA; Talsma, CE; Flack, CG; Crowley, JG; Hamm, LL; He, XB; Hervey-Jumper, SL; Heth, JA; Muraszko, KM; DiMeco, F; Vescovi, AL; Fan, X,期刊：Cancer research, 页码：6061-6072 , 文章类型： Article，,卷期：2011年71-18]
- One important function of endothelial cells in glioblastoma multiforme (GBM) is to create a niche that helps promote self-renewal of cancer stem-like cells (CSLC). However, the underlying molecular mechanism for this end...
- DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo
[作者：Li, JL; Sainson, RCA; Oon, CE; Turley, H; Leek, R; Sheldon, H; Bridges, E; Shi, W; Snell, C; Bowden, ET; Wu, HR; Chowdhury, PS; Russell, AJ; Montgomery, CP; Poulsom, R; Harris, AL,期刊：Cancer research, 页码：6073-6083 , 文章类型： Article，,卷期：2011年71-18]
- Resistance to VEGF inhibitors is emerging as a major clinical problem. Notch signaling has been implicated in tumor angiogenesis. Therefore, to investigate mechanisms of resistance to angiogenesis inhibitors, we transduc...
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