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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共36条记录   Antiangiogenic and Antimetastatic Activity of JAK Inhibitor AZD1480 [作者：Xin, H; Herrmann, A; Reckamp, K; Zhang, W; Pal, S; Hedvat, M; Zhang, CY; Liang, W; Scuto, A; Weng, SB; Morosini, D; Cao, ZA; Zinda, M; Figlin, R; Huszar, D; Jove, R; Yu, H,期刊：Cancer research, 页码：6601-6610 , 文章类型： Article，,卷期：2011年71-21] STAT3 has important functions in both tumor cells and the tumor microenvironment to facilitate cancer progression. The STAT regulatory kinase Janus-activated kinase (JAK) has been strongly implicated in promoting oncogen... PAR-1 and Thrombin: The Ties That Bind the Microenvironment to Melanoma Metastasis [作者：Zigler, M; Kamiya, T; Brantley, EC; Villares, GJ; Bar-Eli, M,期刊：Cancer research, 页码：6561-6566 , 文章类型： Review，,卷期：2011年71-21] Progression of melanoma is dependent on cross-talk between tumor cells and the adjacent microenvironment. The thrombin receptor, protease-activated receptor-1 (PAR-1), plays a key role in exerting this function during me... Prospects for TIM3-Targeted Antitumor Immunotherapy [作者：Ngiow, SF; Teng, MWL; Smyth, MJ,期刊：Cancer research, 页码：6567-6571 , 文章类型： Review，,卷期：2011年71-21] New insights into the control of T-cell activation and proliferation have led to the identification of checkpoint proteins that either up-or downmodulate T-cell reactivity. Monoclonal antibody immunotherapies that are re... Is Co-option a Prevailing Mechanism during Cancer Progression? [作者：Billaud, M; Santoro, M,期刊：Cancer research, 页码：6572-6575 , 文章类型： Article，,卷期：2011年71-21] Cancer progression results from the accumulation of genetic and epigenetic alterations that provide tumor cells with a selective advantage. The consecutive cycles of mutations, selections, and clonal expansions generate,... Sphingosine Kinase Inhibitors and Cancer: Seeking the Golden Sword of Hercules [作者：Pyne, S; Bittman, R; Pyne, NJ,期刊：Cancer research, 页码：6576-6582 , 文章类型： Article，,卷期：2011年71-21] There is considerable evidence that sphingosine kinases play a key role in cancer progression, which might involve positive selection of cancer cells that have been provided with a survival and growth advantage as a cons... Oxygen Is a Master Regulator of the Immunogenicity of Primary Human Glioma Cells [作者：Olin, MR; Andersen, BM; Litterman, AJ; Grogan, PT; Sarver, AL; Robertson, PT; Liang, XQ; Chen, W; Parney, IF; Hunt, MA; Blazar, BR; Ohlfest, JR,期刊：Cancer research, 页码：6583-6589 , 文章类型： Article，,卷期：2011年71-21] With recent approval of the first dendritic cell (DC) vaccine for patient use, many other DC vaccine approaches are now being tested in clinical trials. Many of these DC vaccines employ tumor cell lysates (TL) generated ... Aberrant Lipid Metabolism in Hepatocellular Carcinoma Revealed by Plasma Metabolomics and Lipid Profiling [作者：Patterson, AD; Maurhofer, O; Beyoglu, D; Lanz, C; Krausz, KW; Pabst, T; Gonzalez, FJ; Dufour, JF; Idle, JR,期刊：Cancer research, 页码：6590-6600 , 文章类型： Article，,卷期：2011年71-21] There has been limited analysis of the effects of hepatocellular carcinoma (HCC) on liver metabolism and circulating endogenous metabolites. Here, we report the findings of a plasma metabolomic investigation of HCC patie... Targeting the Immunoregulator SRA/CD204 Potentiates Specific Dendritic Cell Vaccine-Induced T-cell Response and Antitumor Immunity [作者：Yi, HF; Guo, CQ; Yu, XF; Gao, P; Qian, J; Zuo, DM; Manjili, MH; Fisher, PB; Subjeck, JR; Wang, XY,期刊：Cancer research, 页码：6611-6620 , 文章类型： Article，,卷期：2011年71-21] Although dendritic cell (DC) vaccines offer promise as cancer immunotherapy, further improvements are needed to amplify their clinical therapeutic efficacy. The pattern recognition scavenger receptor SRA/CD204 attenuates... Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition [作者：Mamessier, E; Sylvain, A; Bertucci, F; Castellano, R; Finetti, P; Houvenaeghel, G; Charaffe-Jaufret, E; Birnbaum, D; Moretta, A; Olive, D,期刊：Cancer research, 页码：6621-6632 , 文章类型： Article，,卷期：2011年71-21] Breast cancer is the leading cause of death for women between the ages of 35 to 65. This is mostly due to intertumor heterogeneity and the lack of specific therapies for all subtypes. However, some breast cancers with an... HB-EGF and PDGF Mediate Reciprocal Interactions of Carcinoma Cells with Cancer-Associated Fibroblasts to Support Progression of Uterine Cervical Cancers [作者：Murata, T; Mizushima, H; Chinen, I; Moribe, H; Yagi, S; Hoffman, RM; Kimura, T; Yoshino, K; Ueda, Y; Enomoto, T; Mekada, E,期刊：Cancer research, 页码：6633-6642 , 文章类型： Article，,卷期：2011年71-21] Tumor stroma drives the growth and progression of cancers. A heparin-binding epidermal growth factor-like growth factor, HB-EGF, is an EGF receptor ligand that stimulates cell growth in an autocrine or paracrine fashion.... Human Cytomegalovirus US28 Found in Glioblastoma Promotes an Invasive and Angiogenic Phenotype [作者：Soroceanu, L; Matlaf, L; Bezrookove, V; Harkins, L; Martinez, R; Greene, M; Soteropoulos, P; Cobbs, CS,期刊：Cancer research, 页码：6643-6653 , 文章类型： Article，,卷期：2011年71-21] Human cytomegalovirus (HCMV) infections are seen often in glioblastoma multiforme (GBM) tumors, but whether the virus contributes to GBM pathogenesis is unclear. In this study, we explored an oncogenic role for the G-pro... SIRT1 Is Essential for Oncogenic Signaling by Estrogen/Estrogen Receptor alpha in Breast Cancer [作者：Elangovan, S; Ramachandran, S; Venkatesan, N; Ananth, S; Gnana-Prakasam, JP; Martin, PM; Browning, DD; Schoenlein, PV; Prasad, PD; Ganapathy, V; Thangaraju, M,期刊：Cancer research, 页码：6654-6664 , 文章类型： Article，,卷期：2011年71-21] The NAD-dependent histone deacetylase silent information regulator 1 (SIRT1) is overexpressed and catalytically activated in a number of human cancers, but recent studies have actually suggested that it may function as a... Progression of Human Bronchioloalveolar Carcinoma to Invasive Adenocarcinoma Is Modeled in a Transgenic Mouse Model of K-ras-Induced Lung Cancer by Loss of the TGF-beta Type II Receptor [作者：Borczuk, AC; Sole, M; Lu, P; Chen, JL; Wilgus, ML; Friedman, RA; Albelda, SM; Powell, CA,期刊：Cancer research, 页码：6665-6675 , 文章类型： Article，,卷期：2011年71-21] Clinical investigations have suggested that repression of the TGF-beta type II receptor (T beta RII) may be an important step in progression of lung adenocarcinoma from an indolent in situ state to a frank invasive carci... Plasminogen Receptor S100A10 Is Essential for the Migration of Tumor-Promoting Macrophages into Tumor Sites [作者：Phipps, KD; Surette, AP; O'Connell, PA; Waisman, DM,期刊：Cancer research, 页码：6676-6683 , 文章类型： Article，,卷期：2011年71-21] Macrophages are critical drivers of tumor growth, invasion, and metastasis. Movement of macrophages into tumors requires the activity of cell surface proteases such as plasmin. In this study, we offer genetic evidence th... Manganese Superoxide Dismutase Is a p53-Regulated Gene That Switches Cancers between Early and Advanced Stages [作者：Dhar, SK; Tangpong, J; Chaiswing, L; Oberley, TD; St Clair, DK,期刊：Cancer research, 页码：6684-6695 , 文章类型： Article，,卷期：2011年71-21] Manganese superoxide dismutase (MnSOD) plays a critical role in the survival of aerobic life, and its aberrant expression has been implicated in carcinogenesis and tumor resistance to therapy. However, despite extensive ... A Novel MLL5 Isoform That Is Essential to Activate E6 and E7 Transcription in HPV16/18-Associated Cervical Cancers [作者：Yew, CW; Lee, P; Chan, WK; Lim, VKJ; Tay, SK; Tan, TMC; Deng, LW,期刊：Cancer research, 页码：6696-6707 , 文章类型： Article，,卷期：2011年71-21] Human papillomavirus (HPV) is the primary cause of human cervical cancer. The viral proteins E6 and E7 are essential to transform noncancerous epithelial cells into cancerous carcinomas by targeting key tumor suppressors...