- A Comprehensive View of Nuclear Receptor Cancer Cistromes
[作者:Tang, QZ; Chen, YW; Meyer, C; Geistlinger, T; Lupien, M; Wang, Q; Liu, T; Zhang, Y; Brown, M; Liu, XS,期刊:Cancer research, 页码:6940-6947 , 文章类型: Article,,卷期:2011年71-22]
- Nuclear receptors comprise a superfamily of ligand-activated transcription factors that play important roles in both physiology and diseases including cancer. The technologies of chromatin immunoprecipitation followed by...
- Metabolic Signatures Imaged in Cancer-Induced Cachexia
[作者:Penet, MF; Gadiya, MM; Krishnamachary, B; Nimmagadda, S; Pomper, MG; Artemov, D; Bhujwalla, ZM,期刊:Cancer research, 页码:6948-6956 , 文章类型: Article,,卷期:2011年71-22]
- Cancer-induced cachexia is a complex and poorly understood life-threatening syndrome that is characterized by progressive weight loss due to metabolic alterations, depletion of lipid stores, and severe loss of skeletal m...
- Volumetric and Angiogenic Evaluation of Antitumor Effects with Acoustic Liposome and High-Frequency Ultrasound
[作者:Kodama, T; Tomita, N; Yagishita, Y; Horie, S; Funamoto, K; Hayase, T; Sakamoto, M; Mori, S,期刊:Cancer research, 页码:6957-6964 , 文章类型: Article,,卷期:2011年71-22]
- Acoustic liposomes (AL) have their inherent echogenicity and can add functionality in serving as drug carriers with tissue specificity. Nonuniform vascular structures and vascular branches/bends are evaluated by imaging ...
- Combined Blockade of Integrin-alpha 4 beta 1 Plus Cytokines SDF-1 alpha or IL-1 beta Potently Inhibits Tumor Inflammation and Growth
[作者:Schmid, MC; Avraamides, CJ; Foubert, P; Shaked, Y; Kang, SW; Kerbel, RS; Varner, JA,期刊:Cancer research, 页码:6965-6975 , 文章类型: Article,,卷期:2011年71-22]
- Tumor-associated macrophages promote tumor growth by stimulating angiogenesis and suppressing antitumor immunity. Thus, therapeutics that inhibit macrophage recruitment to tumors may provide new avenues for cancer therap...
- Chemotherapy Enhances Metastasis Formation via VEGFR-1-Expressing Endothelial Cells
[作者:Daenen, LGM; Roodhart, JML; van Amersfoort, M; Dehnad, M; Roessingh, W; Ulfman, LH; Derksen, PWB; Voest, EE,期刊:Cancer research, 页码:6976-6985 , 文章类型: Article,,卷期:2011年71-22]
- Recent studies suggest that chemotherapy, in addition to its cytotoxic effects on tumor cells, can induce a cascade of host events to support tumor growth and spread. Here, we used an experimental pulmonary metastasis mo...
- Host Response to Short-term, Single-Agent Chemotherapy Induces Matrix Metalloproteinase-9 Expression and Accelerates Metastasis in Mice
[作者:Gingis-Velitski, S; Loven, D; Benayoun, L; Munster, M; Bril, R; Voloshin, T; Alishekevitz, D; Bertolini, F; Shaked, Y,期刊:Cancer research, 页码:6986-6996 , 文章类型: Article,,卷期:2011年71-22]
- Mounting evidence suggests that bone marrow-derived cells (BMDC) contribute to tumor growth, angiogenesis, and metastasis. In acute reactions to cancer therapy, several types of BMDCs are rapidly mobilized to home tumors...
- Chemotherapy Induces Intratumoral Expression of Chemokines in Cutaneous Melanoma, Favoring T-cell Infiltration and Tumor Control
[作者:Hong, M; Puaux, AL; Huang, C; Loumagne, L; Tow, C; Mackay, C; Kato, M; Prevost-Blondel, A; Avril, MF; Nardin, A; Abastado, JP,期刊:Cancer research, 页码:6997-7009 , 文章类型: Article,,卷期:2011年71-22]
- T-cell infiltration is known to impact tumor growth and is associated with cancer patient survival. However, the molecular cues that favor T-cell infiltration remain largely undefined. Here, using a genetically engineere...
- ANGPTL4 Induction by Prostaglandin E(2) under Hypoxic Conditions Promotes Colorectal Cancer Progression
[作者:Kim, SH; Park, YY; Kim, SW; Lee, JS; Wang, DZ; DuBois, RN,期刊:Cancer research, 页码:7010-7020 , 文章类型: Article,,卷期:2011年71-22]
- Prostaglandin E(2) (PGE(2)), the most abundant COX-2-derived prostaglandin found in colorectal cancer, promotes tumor cell proliferation and survival via multiple signaling pathways. However, the role of PGE(2) in tumor ...
- MYB Is Essential for Mammary Tumorigenesis
[作者:Miao, RY; Drabsch, Y; Cross, RS; Cheasley, D; Carpinteri, S; Pereira, L; Malaterre, J; Gonda, TJ; Anderson, RL; Ramsay, RG,期刊:Cancer research, 页码:7029-7037 , 文章类型: Article,,卷期:2011年71-22]
- MYB oncogene upregulation is associated with estrogen receptor (ER)-positive breast cancer, but disease requirements for MYB function in vivo have not been explored. In this study, we provide evidence of a critical requi...
- p53 Negatively Regulates the Hepatoma Growth Factor HDGF
[作者:Sasaki, Y; Negishi, H; Idogawa, M; Yokota, I; Koyama, R; Kusano, M; Suzuki, H; Fujita, M; Maruyama, R; Toyota, M; Saito, T; Tokino, T,期刊:Cancer research, 页码:7038-7047 , 文章类型: Article,,卷期:2011年71-22]
- Hepatoma-derived growth factor (HDGF) is a secreted heparin-binding growth factor that has been implicated in cancer development and progression. Here, we report that HDGF is a critical target for transcriptional repress...
- Increased Skin Papilloma Formation in Mice Lacking Glutathione Transferase GSTP
[作者:Henderson, CJ; Ritchie, KJ; McLaren, A; Chakravarty, P; Wolf, CR,期刊:Cancer research, 页码:7048-7060 , 文章类型: Article,,卷期:2011年71-22]
- The glutathione S-transferase GSTP is overexpressed in many human cancers and chemotherapy-resistant cancer cells, where there is evidence that GSTP may have additional functions beyond its known catalytic role. On the b...
- Sonic Hedgehog Pathway Promotes Metastasis and Lymphangiogenesis via Activation of Akt, EMT, and MMP-9 Pathway in Gastric Cancer
[作者:Yoo, YA; Kang, MH; Lee, HJ; Kim, BH; Park, JK; Kim, HK; Kim, JS; Oh, SC,期刊:Cancer research, 页码:7061-7070 , 文章类型: Article,,卷期:2011年71-22]
- Activation of sonic hedgehog (Shh) signaling has been implicated in progression of a variety of tumors. In this study, we elucidated a role for Shh in the invasion of gastric tumors and determined the mechanism by which ...
- p53 Modulates Acquired Resistance to EGFR Inhibitors and Radiation
[作者:Huang, S; Benavente, S; Armstrong, EA; Li, CR; Wheeler, DL; Harari, PM,期刊:Cancer research, 页码:7071-7079 , 文章类型: Article,,卷期:2011年71-22]
- There is presently great interest in mechanisms of acquired resistance to epidermal growth factor receptor (EGFR) inhibitors that are now being used widely in the treatment of a variety of common human cancers. To invest...
- Epithelial Junction Opener JO-1 Improves Monoclonal Antibody Therapy of Cancer
[作者:Beyer, I; van Rensburg, R; Strauss, R; Li, ZY; Wang, HJ; Persson, J; Yumul, R; Feng, QH; Song, H; Bartek, J; Fender, P; Lieber, A,期刊:Cancer research, 页码:7080-7090 , 文章类型: Article,,卷期:2011年71-22]
- The efficacy of monoclonal antibodies (mAb) used to treat solid tumors is limited by intercellular junctions which tightly link epithelial tumor cells to each another. In this study, we define a small, recombinant adenov...
- AGR2 Is a Novel Surface Antigen That Promotes the Dissemination of Pancreatic Cancer Cells through Regulation of Cathepsins B and D
[作者:Dumartin, L; Whiteman, HJ; Weeks, ME; Hariharan, D; Dmitrovic, B; Iacobuzio-Donahue, CA; Brentnall, TA; Bronner, MP; Feakins, RM; Timms, JF; Brennan, C; Lemoine, NR; Crnogorac-Jurcevic, T,期刊:Cancer research, 页码:7091-7102 , 文章类型: Article,,卷期:2011年71-22]
- Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers largely due to disseminated disease at the time of presentation. Here, we investigated the role and mechanism of action of the metastasis-ass...
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