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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共37条记录   Targets of the Tumor Suppressor miR-200 in Regulation of the Epithelial-Mesenchymal Transition in Cancer [作者：Schliekelman, MJ; Gibbons, DL; Faca, VM; Creighton, CJ; Rizvi, ZH; Zhang, Q; Wong, CH; Wang, H; Ungewiss, C; Ahn, YH; Shin, DH; Kurie, JM; Hanash, SM,期刊：Cancer research, 页码：7670-7682 , 文章类型： Article，,卷期：2011年71-24] The microRNA-200 (miR-200) family restricts epithelial-mesenchymal transition (EMT) and metastasis in tumor cell lines derived from mice that develop metastatic lung adenocarcinoma. To determine the mechanisms responsibl... Selectin Ligand Sialyl-Lewis x Antigen Drives Metastasis of Hormone-Dependent Breast Cancers [作者：Julien, S; Ivetic, A; Grigoriadis, A; Qize, D; Burford, B; Sproviero, D; Picco, G; Gillett, C; Papp, SL; Schaffer, L; Tutt, A; Taylor-Papadimitriou, J; Pinder, SE; Burchell, JM,期刊：Cancer research, 页码：7683-7693 , 文章类型： Article，,卷期：2011年71-24] The glycome acts as an essential interface between cells and the surrounding microenvironment. However, changes in glycosylation occur in nearly all breast cancers, which can alter this interaction. Here, we report that ... GLIPR1 Suppresses Prostate Cancer Development through Targeted Oncoprotein Destruction [作者：Li, LK; Ren, CZ; Yang, G; Fattah, EA; Goltsov, AA; Kim, SM; Lee, JS; Park, S; Demayo, FJ; Ittmann, MM; Troncoso, P; Thompson, TC,期刊：Cancer research, 页码：7694-7704 , 文章类型： Article，,卷期：2011年71-24] Downregulation of the proapoptotic p53 target gene glioma pathogenesis-related protein 1 (GLIPR1) occurs frequently in prostate cancer, but the functional meaning of this event is obscure. Here, we report the discovery o... The Evolution of Endothelial Regulatory Paradigms in Cancer Biology and Vascular Repair [作者：Franses, JW; Edelman, ER,期刊：Cancer research, 页码：7339-7344 , 文章类型： Review，,卷期：2011年71-24] Although the roles of endothelial cells in cancer have primarily been considered to be related to tumor perfusion, the emerging appreciation of "angiocrine" regulation adds stromal regulatory capabilities to the expandin... The Pax-5 Gene: A Pluripotent Regulator of B-cell Differentiation and Cancer Disease [作者：O'Brien, P; Morin, P; Ouellette, RJ; Robichaud, GA,期刊：Cancer research, 页码：7345-7350 , 文章类型： Review，,卷期：2011年71-24] The Pax-5 oncogene encodes a potent transcription factor that plays a key role in B-cell development and cancerous processes. In normal B-lymphopoiesis, Pax-5 accomplishes a dual function by activating B-cell commitment ... Targeting PI3K/mTOR Signaling in Cancer [作者：Emerling, BM; Akcakanat, A,期刊：Cancer research, 页码：7351-7359 , 文章类型： Editorial Material，,卷期：2011年71-24] The American Association for Cancer Research (AACR) Special Conference on Targeting PI3K/mTOR Signaling in Cancer was held in San Francisco, California from February 24 to 27, 2011. The meeting was cochaired by Drs. Lewi... 5-Hydroxymethylcytosine Is Strongly Depleted in Human Cancers but Its Levels Do Not Correlate with IDH1 Mutations [作者：Jin, SG; Jiang, Y; Qiu, RX; Rauch, TA; Wang, YS; Schackert, G; Krex, D; Lu, Q; Pfeifer, GP,期刊：Cancer research, 页码：7360-7365 , 文章类型： Article，,卷期：2011年71-24] The base 5-hydroxymethylcytosine (5hmC) was recently identified as an oxidation product of 5-methylcytosine in mammalian DNA. Here, using sensitive and quantitative methods to assess levels of 5-hydroxymethyl-2'-deoxycyt... Quantifying the Role of Angiogenesis in Malignant Progression of Gliomas: In Silico Modeling Integrates Imaging and Histology [作者：Swanson, KR; Rockne, RC; Claridge, J; Chaplain, MA; Alvord, EC; Anderson, ARA,期刊：Cancer research, 页码：7366-7375 , 文章类型： Article，,卷期：2011年71-24] Gliomas are uniformly fatal forms of primary brain neoplasms that vary from low-to high-grade (glioblastoma). Whereas low-grade gliomas are weakly angiogenic, glioblastomas are among the most angiogenic tumors. Thus, int... Metabolomic Profiling Reveals Potential Markers and Bioprocesses Altered in Bladder Cancer Progression [作者：Putluri, N; Shojaie, A; Vasu, VT; Vareed, SK; Nalluri, S; Putluri, V; Thangjam, GS; Panzitt, K; Tallman, CT; Butler, C; Sana, TR; Fischer, SM; Sica, G; Brat, DJ; Shi, HD; Palapattu, GS; Lotan, Y; Weizer, AZ; Terris, MK; Shariat, SF; Michailidis, G; Sreekumar, A,期刊：Cancer research, 页码：7376-7386 , 文章类型： Article，,卷期：2011年71-24] Although alterations in xenobiotic metabolism are considered causal in the development of bladder cancer, the precise mechanisms involved are poorly understood. In this study, we used high-throughput mass spectrometry to... In Vivo Magnetic Resonance Imaging of the Estrogen Receptor in an Orthotopic Model of Human Breast Cancer [作者：Pais, A; Gunanathan, C; Margalit, R; Biton, IE; Yosepovich, A; Milstein, D; Degani, H,期刊：Cancer research, 页码：7387-7397 , 文章类型： Article，,卷期：2011年71-24] Histologic overexpression of the estrogen receptor a (ER) is a well-established prognostic marker in breast cancer. Noninvasive imaging techniques that could detect ER overexpression would be useful in a variety of setti... A Framework to Select Clinically Relevant Cancer Cell Lines for Investigation by Establishing Their Molecular Similarity with Primary Human Cancers [作者：Dancik, GM; Ru, YB; Owens, CR; Theodorescu, D,期刊：Cancer research, 页码：7398-7409 , 文章类型： Article，,卷期：2011年71-24] Experimental work on human cancer cell lines often does not translate to the clinic. We posit that this is because some cells undergo changes in vitro that no longer make them representative of human tumors. Here, we des... Functional Characterization of an scFv-Fc Antibody that Immunotherapeutically Targets the Common Cancer Cell Surface Proteoglycan CSPG4 [作者：Wang, XH; Katayama, A; Wang, YY; Yu, L; Favoino, E; Sakakura, K; Favole, A; Tsuchikawa, T; Silver, S; Watkins, SC; Kageshita, T; Ferrone, S,期刊：Cancer research, 页码：7410-7422 , 文章类型： Article，,卷期：2011年71-24] Cell surface chondroitin sulfate proteoglycan 4 (CSPG4) is an attractive target for antibody-based cancer immunotherapy because of its role in tumor cell biology, its high expression on malignant cells including cancer-i... Smad7 Expression in T cells Prevents Colitis- Associated Cancer [作者：Rizzo, A; Waldner, MJ; Stolfi, C; Sarra, M; Fina, D; Becker, C; Neurath, MF; Macdonald, TT; Pallone, F; Monteleone, G; Fantini, MC,期刊：Cancer research, 页码：7423-7432 , 文章类型： Article，,卷期：2011年71-24] Patients with inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer due to chronic inflammation. In IBD, chronic inflammation relies upon a TGF beta signaling blockade, but its precise m... Hypoxia Induces Escape from Innate Immunity in Cancer Cells via Increased Expression of ADAM10: Role of Nitric Oxide [作者：Barsoum, IB; Hamilton, TK; Li, X; Cotechini, T; Miles, EA; Siemens, DR; Graham, CH,期刊：Cancer research, 页码：7433-7441 , 文章类型： Article，,卷期：2011年71-24] One key to malignant progression is the acquired ability of tumor cells to escape immune-mediated lysis. Whereas tumor hypoxia is known to play a causal role in cancer metastasis and resistance to therapy, the link betwe... Dendritic Cell Internalization of alpha-Galactosylceramide from CD8 T Cells Induces Potent Antitumor CD8 T-cell Responses [作者：Choi, DH; Kim, KS; Yang, SH; Chung, DH; Song, B; Sprent, J; Cho, JH; Sung, YC,期刊：Cancer research, 页码：7442-7451 , 文章类型： Article，,卷期：2011年71-24] Dendritic cells (DC) present a-galactosylceramide (alpha GalCer) to invariant T-cell receptor-expressing natural killer T cells (iNKT) activating these cells to secrete a variety of cytokines, which in turn results in DC... Peptide-Conjugated PAMAM Dendrimer as a Universal DNA Vaccine Platform to Target Antigen-Presenting Cells [作者：Daftarian, P; Kaifer, AE; Li, W; Blomberg, BB; Frasca, D; Roth, F; Chowdhury, R; Berg, EA; Fishman, JB; Al Sayegh, HA; Blackwelder, P; Inverardi, L; Perez, VL; Lemmon, V; Serafini, P,期刊：Cancer research, 页码：7452-7462 , 文章类型： Article，,卷期：2011年71-24] DNA-based vaccines hold promise to outperform conventional antigen-based vaccines by virtue of many unique features. However, DNA vaccines have thus far fallen short of expectations, due in part to poor targeting of prof...