- FoxM1: A Master Regulator of Tumor Metastasis
[作者：Raychaudhuri, P; Park, HJ,期刊：Cancer research, 页码：4329-4333 , 文章类型： Review，,卷期：2011年71-13]
- The FoxM1 transcription factor gene is overexpressed in cancer. Its expression is stimulated by oncogenic signaling pathways and reactive oxygen species. It is also a target of regulation by the tumor suppressor genes. T...
- The Death of the Cancer Cell
[作者：Sonnenschein, C; Soto, AM,期刊：Cancer research, 页码：4334-4337 , 文章类型： Article，,卷期：2011年71-13]
- For a century, the perception that there are qualitative differences between a normal cell and a cell belonging to a tumor has dominated discussions aimed at explaining cancer. However, an analysis of the experimental ev...
- Tumor Immunology: Basic and Clinical Advances
[作者：Beatty, PL; Cascio, S; Lutz, E,期刊：Cancer research, 页码：4338-4343 , 文章类型： Article，,卷期：2011年71-13]
- The third in a series of AACR conferences, entitled "Tumor Immunology: Basic and Clinical Advances," was held in Miami Beach, Florida from November 30 to December 3, 2010. The overall objective of this meeting was to dis...
- Luminal Expression of PIK3CA Mutant H1047R in the Mammary Gland Induces Heterogeneous Tumors
[作者：Meyer, DS; Brinkhaus, H; Muller, U; Muller, M; Cardiff, RD; Bentires-Alj, M,期刊：Cancer research, 页码：4344-4351 , 文章类型： Article，,卷期：2011年71-13]
- The phosphoinositide 3-kinase (PI3K) signaling cascade, a key mediator of cellular survival, growth, and metabolism, is frequently altered in human cancer. Activating mutations in PIK3CA, which encodes the a-catalytic su...
- Functional Parsing of Driver Mutations in the Colorectal Cancer Genome Reveals Numerous Suppressors of Anchorage-Independent Growth
[作者：Eskiocak, U; Kim, SB; Ly, P; Roig, AI; Biglione, S; Komurov, K; Cornelius, C; Wright, WE; White, MA; Shay, JW,期刊：Cancer research, 页码：4359-4365 , 文章类型： Article，,卷期：2011年71-13]
- Landmark cancer genome resequencing efforts are leading to the identification of mutated genes in many types of cancer. The extreme diversity of mutations being detected presents significant challenges to subdivide causa...
- Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1
[作者：Ben Sahra, I; Regazzetti, C; Robert, G; Laurent, K; Le Marchand-Brustel, Y; Auberger, P; Tanti, JF; Giorgetti-Peraldi, S; Bost, F,期刊：Cancer research, 页码：4366-4372 , 文章类型： Article，,卷期：2011年71-13]
- Metformin is a widely prescribed antidiabetic drug associated with a reduced risk of cancer. Many studies show that metformin inhibits cancer cell viability through the inhibition of mTOR. We recently showed that antipro...
- Physical Association of HDAC1 and HDAC2 with p63 Mediates Transcriptional Repression and Tumor Maintenance in Squamous Cell Carcinoma
[作者：Ramsey, MR; He, L; Forster, N; Ory, B; Ellisen, LW,期刊：Cancer research, 页码：4373-4379 , 文章类型： Article，,卷期：2011年71-13]
- Squamous cell carcinoma (SCC) is a treatment-refractory subtype of human cancer arising from stratified epithelium of the skin, lung, esophagus, oropharynx, and other tissues. A unifying feature of SCC is high-level expr...
- HER2 Overexpression Elicits a Proinflammatory IL-6 Autocrine Signaling Loop That Is Critical for Tumorigenesis
[作者：Hartman, ZC; Yang, XY; Glass, O; Lei, GJ; Osada, T; Dave, SS; Morse, MA; Clay, TM; Lyerly, HK,期刊：Cancer research, 页码：4380-4391 , 文章类型： Article，,卷期：2011年71-13]
- HER2 overexpression occurs in approximately 25% of breast cancers, where it correlates with poor prognosis. Likewise, systemic inflammation in breast cancer correlates with poor prognosis, although the process is not und...
- Blocking EphB1 Receptor Forward Signaling in Spinal Cord Relieves Bone Cancer Pain and Rescues Analgesic Effect of Morphine Treatment in Rodents
[作者：Liu, S; Liu, WT; Liu, YP; Dong, HL; Henkemeyer, M; Xiong, LZ; Song, XJ,期刊：Cancer research, 页码：4392-4402 , 文章类型： Article，,卷期：2011年71-13]
- Treating bone cancer pain continues to be a clinical challenge and underlying mechanisms of bone cancer pain remain elusive. Here, we report that EphB1 receptor forward signaling in the spinal cord is critical to the dev...
- HDAC4-Regulated STAT1 Activation Mediates Platinum Resistance in Ovarian Cancer
[作者：Stronach, EA; Alfraidi, A; Rama, N; Datler, C; Studd, JB; Agarwal, R; Guney, TG; Gourley, C; Hennessy, BT; Mills, GB; Mai, A; Brown, R; Dina, R; Gabra, H,期刊：Cancer research, 页码：4412-4422 , 文章类型： Article，,卷期：2011年71-13]
- Ovarian cancer frequently acquires resistance to platinum chemotherapy, representing a major challenge for improving patient survival. Recent work suggests that resistant clones exist within a larger drug-sensitive cell ...
- Tumor Galectin-1 Mediates Tumor Growth and Metastasis through Regulation of T-Cell Apoptosis
[作者：Banh, A; Zhang, J; Cao, HB; Bouley, DM; Kwok, S; Kong, C; Giaccia, AJ; Koong, AC; Le, QT,期刊：Cancer research, 页码：4423-4431 , 文章类型： Article，,卷期：2011年71-13]
- Galectin-1 (Gal-1), a carbohydrate-binding protein whose secretion is enhanced by hypoxia, promotes tumor aggressiveness by promoting angiogenesis and T-cell apoptosis. However, the importance of tumor versus host Gal-1 ...
- Pancreatic Ductal Adenocarcinoma Mice Lacking Mucin 1 Have a Profound Defect in Tumor Growth and Metastasis
[作者：Besmer, DM; Curry, JM; Roy, LD; Tinder, TL; Sahraei, M; Schettini, J; Hwang, SI; Lee, YY; Gendler, SJ; Mukherjee, P,期刊：Cancer research, 页码：4432-4442 , 文章类型： Article，,卷期：2011年71-13]
- MUC1 is overexpressed and aberrantly glycosylated in more than 60% of pancreatic ductal adenocarcinomas. The functional role of MUC1 in pancreatic cancer has yet to be fully elucidated due to a dearth of appropriate mode...
- MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing
[作者：Farazi, TA; Horlings, HM; ten Hoeve, JJ; Mihailovic, A; Halfwerk, H; Morozov, P; Brown, M; Hafner, M; Reyal, F; van Kouwenhove, M; Kreike, B; Sie, D; Hovestadt, V; Wessels, LFA; van de Vijver, MJ; Tuschl, T,期刊：Cancer research, 页码：4443-4453 , 文章类型： Article，,卷期：2011年71-13]
- MicroRNAs (miRNA) regulate many genes critical for tumorigenesis. We profiled miRNAs from 11 normal breast tissues, 17 noninvasive, 151 invasive breast carcinomas, and 6 cell lines by in-house-developed barcoded Solexa s...
- Hedgehog-Producing Cancer Cells Respond to and Require Autocrine Hedgehog Activity
[作者：Singh, S; Wang, ZQ; Fei, DL; Black, KE; Goetz, JA; Tokhunts, R; Giambelli, C; Rodriguez-Blanco, J; Long, J; Lee, E; Briegel, KJ; Bejarano, PA; Dmitrovsky, E; Capobianco, AJ; Robbins, DJ,期刊：Cancer research, 页码：4454-4463 , 文章类型： Article，,卷期：2011年71-13]
- A number of Smoothened (SMO) pathway antagonists are currently undergoing clinical trials as anticancer agents. These drugs are proposed to attenuate tumor growth solely through inhibition of Hedgehog (HH), which is prod...
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