- Ex Vivo Graft Purging and Expansion of Autologous Blood Progenitor Cell Products from Patients with Multiple Myeloma
[作者:Yang, H; Robinson, SN; Nieto, Y; Jones, RJ; Gocke, CD; Lu, JJ; Giralt, SA; Jones, RB; Decker, WK; Xing, DX; Steiner, D; Champlin, RE; McMannis, JD; Ng, JJ; Thomas, MW; Shah, N; Andersson, BS; Parmar, S; Shpall, EJ,期刊:Cancer research, 页码:5040-5049 , 文章类型: Article,,卷期:2011年71-14]
- Autologous peripheral blood progenitor cell (PBPC) transplantation is the treatment of choice for selected myeloma patients. However, tumor cells contaminating the apheresis product are a potential source of relapse. Her...
- Myeloid Suppressor Cells Regulate the Lung Environment-Letter
[作者:Bosiljcic, M; Hamilton, MJ; Banath, JP; LePard, NE; McDougal, DC; Jia, JX; Krystal, G; Bennewith, KL,期刊:Cancer research, 页码:5050-5051 , 文章类型: Letter,,卷期:2011年71-14]
- 4T1 murine mammary carcinoma cells implanted in syngeneic Balb/c mice are increasingly being used in metastasis research, with some groups using this model to study tumor-induced accumulation of bone marrow-derived cells...
- Myeloid Suppressor Cells Regulate the Lung Environment-Response
[作者:Yan, HH; Pickup, M; Pang, YL; Gorska, AE; Li, ZY; Chytil, A; Geng, YP; Gray, JW; Moses, HL; Yang, L,期刊:Cancer research, 页码:5052-5053 , 文章类型: Letter,,卷期:2011年71-14]
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- Immunoregulatory Molecule B7-H1 (CD274) Contributes to Skin Carcinogenesis
[作者:Cao, YJ; Zhang, L; Ritprajak, P; Tsushima, F; Youngnak-Piboonratanakit, P; Kamimura, Y; Hashiguchi, M; Azuma, M,期刊:Cancer research, 页码:4737-4741 , 文章类型: Review,,卷期:2011年71-14]
- B7-H1 (CD274), a member of the B7 family of coinhibitory molecules, is often induced in human tumors and its expression is closely correlated with a poor prognosis or higher malignancy grade. Tumor-associated B7-H1 is im...
- In Vivo Programming of Tumor Antigen-Specific T Lymphocytes from Pluripotent Stem Cells to Promote Cancer Immunosurveillance
[作者:Lei, FY; Zhao, BH; Haque, R; Xiong, XF; Budgeon, L; Christensen, ND; Wu, YZ; Song, JX,期刊:Cancer research, 页码:4742-4747 , 文章类型: Article,,卷期:2011年71-14]
- Adoptive T-cell immunotherapy has garnered wide attention, but its effective use is limited by the need of multiple ex vivo manipulations and infusions that are complex and expensive. In this study, we show how highly re...
- Preconditioned Endothelial Progenitor Cells Reduce Formation of Melanoma Metastases through SPARC-Driven Cell-Cell Interactions and Endocytosis
[作者:Defresne, F; Bouzin, C; Grandjean, M; Dieu, M; Raes, M; Hatzopoulos, AK; Kupatt, C; Feron, O,期刊:Cancer research, 页码:4748-4757 , 文章类型: Article,,卷期:2011年71-14]
- Tumor progression is associated with the release of signaling substances from the primary tumor into the bloodstream. Tumor-derived cytokines are known to promote the mobilization and the recruitment of cells from the bo...
- VEGF and c-Met Blockade Amplify Angiogenesis Inhibition in Pancreatic Islet Cancer
[作者:You, WK; Sennino, B; Williamson, CW; Falcon, B; Hashizume, H; Yao, LC; Aftab, DT; McDonald, DM,期刊:Cancer research, 页码:4758-4768 , 文章类型: Article,,卷期:2011年71-14]
- Angiogenesis inhibitors that block VEGF receptor (VEGFR) signaling slow the growth of many types of tumors, but eventually the disease progresses. Multiple strategies are being explored to improve efficacy by concurrent ...
- Podoplanin-Positive Fibroblasts Enhance Lung Adenocarcinoma Tumor Formation: Podoplanin in Fibroblast Functions for Tumor Progression
[作者:Hoshino, A; Ishii, G; Ito, T; Aoyagi, K; Ohtaki, Y; Nagai, K; Sasaki, H; Ochiai, A,期刊:Cancer research, 页码:4769-4779 , 文章类型: Article,,卷期:2011年71-14]
- During the metastatic process, cancer cells interact with vascular adventitial fibroblasts (VAF), which are the main components of the outermost connective tissue layer of blood vessels. This activity suggests the presen...
- IL-7 Contributes to the Progression of Human T-cell Acute Lymphoblastic Leukemias
[作者:Silva, A; Laranjeira, ABA; Martins, LR; Cardoso, BA; Demengeot, J; Yunes, JA; Seddon, B; Barata, JT,期刊:Cancer research, 页码:4780-4789 , 文章类型: Article,,卷期:2011年71-14]
- The importance of microenvironmental factors for driving progression in leukemia has been debated. Previous evidence has pointed to interleukin-7 (IL-7), a fundamental cytokine to normal T-cell development and homeostasi...
- Memory Type 2 Helper T Cells Induce Long-Lasting Antitumor Immunity by Activating Natural Killer Cells
[作者:Kitajima, M; Ito, T; Tumes, DJ; Endo, Y; Onodera, A; Hashimoto, K; Motohashi, S; Yamashita, M; Nishimura, T; Ziegler, SF; Nakayama, T,期刊:Cancer research, 页码:4790-4798 , 文章类型: Article,,卷期:2011年71-14]
- Functionally polarized helper T cells (Th cells) play crucial roles in the induction of tumor immunity. There is considerable knowledge about the contributions of IFN-producing Th1 cells that supports the role of cytotox...
- CD8(+) T Cells Regulate Bone Tumor Burden Independent of Osteoclast Resorption
[作者:Zhang, KH; Kim, S; Cremasco, V; Hirbe, AC; Novack, DV; Weilbaecher, K; Faccio, R,期刊:Cancer research, 页码:4799-4808 , 文章类型: Article,,卷期:2011年71-14]
- Blockade of osteoclast (OC) activity efficiently decreases tumor burden as well as associated bone erosion in immune-compromised animals bearing human osteolytic cancers. In this study, we showed that modulation of antit...
- Pivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors
[作者:Mattarollo, SR; Loi, S; Duret, H; Ma, YT; Zitvogel, L; Smyth, MJ,期刊:Cancer research, 页码:4809-4820 , 文章类型: Article,,卷期:2011年71-14]
- We show, in a series of established experimental breast adenocarcinomas and fibrosarcomas induced by carcinogen de novo in mice, that the therapeutic efficacy of doxorubicin treatment is dependent on CD8 T cells and IFN-...
- Human Tumor Cells Killed by Anthracyclines Induce a Tumor-Specific Immune Response
[作者:Fucikova, J; Kralikova, P; Fialova, A; Brtnicky, T; Rob, L; Bartunkova, J; Spisek, R,期刊:Cancer research, 页码:4821-4833 , 文章类型: Article,,卷期:2011年71-14]
- Immunogenic cell death is characterized by the early surface exposure of chaperones including calreticulin and HSPs, which affect dendritic cell (DC) maturation and the uptake and presentation of tumor antigens. It has a...
- Human Neural Stem Cell Transplantation Ameliorates Radiation-Induced Cognitive Dysfunction
[作者:Acharya, MM; Christie, LA; Lan, ML; Giedzinski, E; Fike, JR; Rosi, S; Limoli, CL,期刊:Cancer research, 页码:4834-4845 , 文章类型: Article,,卷期:2011年71-14]
- Cranial radiotherapy induces progressive and debilitating declines in cognition that may, in part, be caused by the depletion of neural stem cells. The potential of using stem cell replacement as a strategy to combat rad...
- Engagement of I-Branching beta-1, 6-N-Acetylglucosaminyltransferase 2 in Breast Cancer Metastasis and TGF-beta Signaling
[作者:Zhang, HJ; Meng, FY; Wu, SW; Kreike, B; Sethi, S; Chen, W; Miller, FR; Wu, GJ,期刊:Cancer research, 页码:4846-4856 , 文章类型: Article,,卷期:2011年71-14]
- In this study, we have showed that GCNT2, a gene-encoding glucosaminyl (N-acetyl) transferase 2, I-branching enzyme, is overexpressed in highly metastatic breast cancer cell lines of human and mouse origin and basal-like...
- The Mef/Elf4 Transcription Factor Fine Tunes the DNA Damage Response
[作者:Sashida, G; Bae, N; Di Giandomenico, S; Asai, T; Gurvich, N; Bazzoli, E; Liu, Y; Huang, G; Zhao, XY; Menendez, S; Nimer, SD,期刊:Cancer research, 页码:4857-4865 , 文章类型: Article,,卷期:2011年71-14]
- The ATM kinase plays a critical role in initiating the DNA damage response that is triggered by genotoxic stresses capable of inducing DNA double-strand breaks. Here, we show that ELF4/MEF, a member of the ETS family of ...
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