- Considerations for the Clinical Application of Chimeric Antigen Receptor T Cells: Observations from a Recombinant DNA Advisory Committee Symposium Held June 15, 2010
[作者：Ertl, HCJ; Zaia, J; Rosenberg, SA; June, CH; Dotti, G; Kahn, J; Cooper, LJN; Corrigan-Curay, J; Strome, SE,期刊：Cancer research, 页码：3175-3181 , 文章类型： Review，,卷期：2011年71-9]
- T cells that are genetically modified to express single-chain chimeric antigen receptors (CAR) have shown promise in early cancer immunotherapy clinical trials. Unfortunately, 2 recent deaths in cancer patients treated w...
- STAT3 Inhibition Is a Therapeutic Strategy for ABC-like Diffuse Large B-Cell Lymphoma
[作者：Scuto, A; Kujawski, M; Kowolik, C; Krymskaya, L; Wang, L; Weiss, LM; DiGiusto, D; Yu, H; Forman, S; Jove, R,期刊：Cancer research, 页码：3182-3188 , 文章类型： Article，,卷期：2011年71-9]
- Persistent STAT3 signaling contributes to malignant progression in many diverse types of human cancer. STAT3 is constitutively active in activated B-cell (ABC)-like diffuse large B-cell lymphomas (DLBCL), a class of nong...
- The ABL Switch Control Inhibitor DCC-2036 Is Active against the Chronic Myeloid Leukemia Mutant BCR-ABL(T315I) and Exhibits a Narrow Resistance Profile
[作者：Eide, CA; Adrian, LT; Tyner, JW; Mac Partlin, M; Anderson, DJ; Wise, SC; Smith, BD; Petillo, PA; Flynn, DL; Deininger, MWN; O'Hare, T; Druker, BJ,期刊：Cancer research, 页码：3189-3195 , 文章类型： Article，,卷期：2011年71-9]
- Acquired point mutations within the BCR-ABL kinase domain represent a common mechanism of resistance to ABL inhibitor therapy in patients with chronic myeloid leukemia (CML). The BCR-ABL(T315I) mutant is highly resistant...
- Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types
[作者：Iliopoulos, D; Hirsch, HA; Struhl, K,期刊：Cancer research, 页码：3196-3201 , 文章类型： Article，,卷期：2011年71-9]
- Metformin, the first-line drug for treating diabetes, selectively kills the chemotherapy resistant sub-population of cancer stem cells (CSC) in genetically distinct types of breast cancer cell lines. In mouse xenografts,...
- Ribonucleotide Reductase Small Subunit M2B Prognoses Better Survival in Colorectal Cancer
[作者：Liu, XY; Lai, L; Wang, XC; Xue, LJ; Leora, S; Wu, J; Hu, SY; Zhang, KQ; Kuo, ML; Zhou, L; Zhang, H; Wang, YF; Wang, Y; Zhou, BS; Nelson, RA; Zheng, S; Zhang, SZ; Chu, PG; Yen, Y,期刊：Cancer research, 页码：3202-3213 , 文章类型： Article，,卷期：2011年71-9]
- Ribonucleotide reductase subunit RRM2B (p53R2) has been reported to suppress invasion and metastasis in colorectal cancer (CRC). Here, we report that high levels of RRM2B expression are correlated with markedly better su...
- Adjuvant Combination and Antigen Targeting as a Strategy to Induce Polyfunctional and High-Avidity T-Cell Responses against Poorly Immunogenic Tumors
[作者：Aranda, F; Llopiz, D; Diaz-Valdes, N; Riezu-Boj, JI; Bezunartea, J; Ruiz, M; Martinez, M; Durantez, M; Mansilla, C; Prieto, J; Lasarte, JJ; Borras-Cuesta, F; Sarobe, P,期刊：Cancer research, 页码：3214-3224 , 文章类型： Article，,卷期：2011年71-9]
- Low antigen expression and an absence of coimmunostimulatory signals may be partly responsible for the low immunogenicity of many tumors. It may be possible to overcome this situation by defining a combination of adjuvan...
- Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression
[作者：Hilvo, M; Denkert, C; Lehtinen, L; Muller, B; Brockmoller, S; Seppanen-Laakso, T; Budczies, J; Bucher, E; Yetukuri, L; Castillo, S; Berg, E; Nygren, H; Sysi-Aho, M; Griffin, JL; Fiehn, O; Loibl, S; Richter-Ehrenstein, C; Radke, C; Hyotylainen, T; Kallioni,期刊：Cancer research, 页码：3236-3245 , 文章类型： Article，,卷期：2011年71-9]
- Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark of many cancers. However, the precise molecular composition of lipids in tumors remains generally poorly characterized. The aim of...
- mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways
[作者：Gulhati, P; Bowen, KA; Liu, JY; Stevens, PD; Rychahou, PG; Chen, M; Lee, EY; Weiss, HL; O'Connor, KL; Gao, TY; Evers, BM,期刊：Cancer research, 页码：3246-3256 , 文章类型： Article，,卷期：2011年71-9]
- Activation of phosphoinositide 3-kinase (PI3K)/Akt signaling is associated with growth and progression of colorectal cancer (CRC). We have previously shown that the mTOR kinase, a downstream effector of PI3K/Akt signalin...
- FOXO1 Inhibits Runx2 Transcriptional Activity and Prostate Cancer Cell Migration and Invasion
[作者：Zhang, HJ; Pan, YQ; Zheng, L; Choe, C; Lindgren, B; Jensen, ED; Westendorf, JJ; Cheng, L; Huang, HJ,期刊：Cancer research, 页码：3257-3267 , 文章类型： Article，,卷期：2011年71-9]
- Prostate cancer patients with regional lymph node involvement at radical prostatectomy often experience disease progression to other organs, with the bone as the predominant site. The transcription factor Runx2 plays an ...
- Association of Specific Genotypes in Metastatic Suppressor HTPAP with Tumor Metastasis and Clinical Prognosis in Hepatocellular Carcinoma
[作者：Ren, N; Wu, JC; Dong, QZ; Sun, HJ; Jia, HL; Li, GC; Sun, BS; Dai, C; Shi, J; Wei, JW; Sheng, YY; Zhou, HJ; Ye, QH; Qin, LX,期刊：Cancer research, 页码：3278-3286 , 文章类型： Article，,卷期：2011年71-9]
- The phosphatidic acid phosphatase HTPAP has been defined as a metastatic suppressor of hepatocellular carcinoma (HCC), but little is known about its function or potential applications as a prognostic marker. In this stud...
- Large-scale Exploration of Gene-Gene Interactions in Prostate Cancer Using a Multistage Genome-wide Association Study
[作者：Ciampa, J; Yeager, M; Amundadottir, L; Jacobs, K; Kraft, P; Chung, C; Wacholder, S; Yu, K; Wheeler, W; Thun, MJ; Divers, WR; Gapstur, S; Albanes, D; Virtamo, J; Weinstein, S; Giovannucci, E; Willett, WC; Cancel-Tassin, G; Cussenot, O; Valeri, A; Hunter, D,期刊：Cancer research, 页码：3287-3295 , 文章类型： Article，,卷期：2011年71-9]
- Recent genome-wide association studies have identified independent susceptibility loci for prostate cancer that could influence risk through interaction with other, possibly undetected, susceptibility loci. We explored e...
- A Simple Approach to Cancer Therapy Afforded by Multivalent Pseudopeptides That Target Cell-Surface Nucleoproteins
[作者：Destouches, D; Page, N; Hamma-Kourbali, Y; Machi, V; Chaloin, O; Frechault, S; Birmpas, C; Katsoris, P; Beyrath, J; Albanese, P; Maurer, M; Carpentier, G; Strub, JM; Van Dorsselaer, A; Muller, S; Bagnard, D; Briand, JP; Courty, J,期刊：Cancer research, 页码：3296-3305 , 文章类型： Article，,卷期：2011年71-9]
- Recent studies have implicated the involvement of cell surface forms of nucleolin in tumor growth. In this study, we investigated whether a synthetic ligand of cell-surface nucleolin known as N6L could exert antitumor ac...
- Inhibition of HIF Prolyl Hydroxylase-2 Blocks Tumor Growth in Mice through the Antiproliferative Activity of TGF beta
[作者：Klotzsche-von Ameln, A; Muschter, A; Mamlouk, S; Kalucka, J; Prade, I; Franke, K; Rezaei, M; Poitz, DM; Breier, G; Wielockx, B,期刊：Cancer research, 页码：3306-3316 , 文章类型： Article，,卷期：2011年71-9]
- Virtually all solid tumors are dependent on a vascular network to provide them with the right amount of nutrients and oxygen. In that sense, low oxygen tension or hypoxia leads to an adaptive response that is transcripti...
- Polo-like Kinase Plk2 Is an Epigenetic Determinant of Chemosensitivity and Clinical Outcomes in Ovarian Cancer
[作者：Syed, N; Coley, HM; Sehouli, J; Koensgen, D; Mustea, A; Szlosarek, P; McNeish, I; Blagden, SP; Schmid, P; Lovell, DP; Hatzimichael, E; Crook, T,期刊：Cancer research, 页码：3317-3327 , 文章类型： Article，,卷期：2011年71-9]
- Resistance to platinum- and taxane-based chemotherapy remains a major clinical impediment to effective management of epithelial ovarian cancer (EOC). To gain insights into resistance mechanisms, we compared gene and conf...
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