- c-Abl Tyrosine Kinase Regulates Serum-induced Nuclear Export of Diacylglycerol Kinase alpha by Phosphorylation at Tyr-218
[作者:Matsubara, T; Ikeda, M; Kiso, Y; Sakuma, M; Yoshino, K; Sakane, F; Merida, I; Saito, N; Shirai, Y,期刊:Journal of Biological Chemistry, 页码:5507-5517 , 文章类型: Article,,卷期:2012年287-8]
- c-Abl is a tyrosine kinase involved in many cellular processes, including cell cycle control and proliferation. However, little is known about its substrates. Here, we show that c-Abl directly phosphorylates diacylglycer...
- Group VIA PLA(2) (iPLA(2)beta) Is Activated Upstream of p38 Mitogen-activated Protein Kinase (MAPK) in Pancreatic Islet beta-Cell Signaling
[作者:Song, HW; Wohltmann, M; Tan, M; Bao, SZ; Ladenson, JH; Turk, J,期刊:Journal of Biological Chemistry, 页码:5528-5541 , 文章类型: Article,,卷期:2012年287-8]
- Group VIA phospholipase A(2) (iPLA(2)beta) in pancreatic islet beta-cells participates in glucose-stimulated insulin secretion and sarco(endo) plasmic reticulum ATPase (SERCA) inhibitor-induced apoptosis, and both are at...
- Heparin-induced Leukocytosis Requires 6-O-Sulfation and Is Caused by Blockade of Selectin- and CXCL12 Protein-mediated Leukocyte Trafficking in Mice
[作者:Zhang, SY; Condac, E; Qiu, H; Jiang, JL; Gutierrez-Sanchez, G; Bergmann, C; Handel, T; Wang, LC,期刊:Journal of Biological Chemistry, 页码:5542-5553 , 文章类型: Article,,卷期:2012年287-8]
- Leukocytosis refers to an increase in leukocyte count above the normal range in the blood and is a common laboratory finding in patients. In many cases, the mechanisms underlying leukocytosis are not known. In this study...
- Fluorescent Recovery after Photobleaching (FRAP) Analysis of Nuclear Export Rates Identifies Intrinsic Features of Nucleocytoplasmic Transport
[作者:Cardarelli, F; Tosti, L; Serresi, M; Beltram, F; Bizzarri, R,期刊:Journal of Biological Chemistry, 页码:5554-5561 , 文章类型: Article,,卷期:2012年287-8]
- A quantitative description of carrier-mediated nuclear export in live cells is presented. To this end, we fused a prototypical leucine-rich nuclear export signal (NES) to GFP as a cargo model and expressed the fluorescen...
- Periconceptional maternal micronutrient supplementation is associated with widespread gender related changes in the epigenome: a study of a unique resource in the Gambia
[作者:Khulan, B; Cooper, WN; Skinner, BM; Bauer, J; Owens, S; Prentice, AM; Belteki, G; Constancia, M; Dunger, D; Affara, NA,期刊:Journal of Biological Chemistry, 页码:1-16 , 文章类型: Article,,卷期:2012年287-8]
- In addition to the genetic constitution inherited by an organism, the developmental trajectory and resulting mature phenotype are also determined by mechanisms acting during critical windows in early life that influence ...
- Functional Regulation of Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1/HPIP) in Erythroid Differentiation
[作者:Manavathi, B; Lo, D; Bugide, S; Dey, O; Imren, S; Weiss, MJ; Humphries, RK,期刊:Journal of Biological Chemistry, 页码:5600-5614 , 文章类型: Article,,卷期:2012年287-8]
- Pre-B-cell leukemia homeobox interacting protein 1 or human PBX1 interacting protein (PBXIP1/HPIP) is a co-repressor of pre-B-cell leukemia homeobox 1 (PBX1) and is also known to regulate estrogen receptor functions by a...
- Metastasis-associated Protein 1 Drives Tumor Cell Migration and Invasion through Transcriptional Repression of RING Finger Protein 144A
[作者:Marzook, H; Li, DQ; Nair, VS; Mudvari, P; Reddy, SDN; Pakala, SB; Santhoshkumar, TR; Pillai, MR; Kumar, R,期刊:Journal of Biological Chemistry, 页码:5615-5626 , 文章类型: Article,,卷期:2012年287-8]
- Metastasis-associated protein 1 (MTA1), a component of the nucleosome-remodeling and histone deacetylase complex, is widely up-regulated in human cancers and significantly correlated with tumor invasion and metastasis, b...
- p63 Regulates Human Keratinocyte Proliferation via MYC-regulated Gene Network and Differentiation Commitment through Cell Adhesion-related Gene Network
[作者:Wu, N; Rollin, J; Masse, I; Lamartine, J; Gidrol, X,期刊:Journal of Biological Chemistry, 页码:5627-5638 , 文章类型: Article,,卷期:2012年287-8]
- Although p63 and MYC are important in the control of epidermal homeostasis, the underlying molecular mechanisms governing keratinocyte proliferation or differentiation downstream of these two genes are not completely und...
- Tyrosine-phosphorylated Galectin-3 Protein Is Resistant to Prostate-specific Antigen (PSA) Cleavage
[作者:Balan, V; Nangia-Makker, P; Kho, DH; Wang, Y; Raz, A,期刊:Journal of Biological Chemistry, 页码:5192-5198 , 文章类型: Article,,卷期:2012年287-8]
- Galectin-3 is a chimeric carbohydrate-binding protein, which interacts with cell surface carbohydrate-containing molecules and extracellular matrix glycoproteins and has been implicated in various biological processes su...
- Dentin Phosphoprotein (DPP) Activates Integrin-mediated Anchorage-dependent Signals in Undifferentiated Mesenchymal Cells
[作者:Eapen, A; Ramachandran, A; George, A,期刊:Journal of Biological Chemistry, 页码:5211-5224 , 文章类型: Article,,卷期:2012年287-8]
- Dentin phosphoprotein (DPP), a major noncollagenous protein of the dentin matrix, is a highly acidic protein that binds Ca2+ avidly and is thus linked to matrix mineralization. Here, we demonstrate that the RGD domain in...
- DNA Methylation-regulated miR-193a-3p Dictates Resistance of Hepatocellular Carcinoma to 5-Fluorouracil via Repression of SRSF2 Expression
[作者:Ma, KL; He, YH; Zhang, HY; Fei, Q; Niu, DD; Wang, DM; Ding, X; Xu, H; Chen, XP; Zhu, JD,期刊:Journal of Biological Chemistry, 页码:5639-5649 , 文章类型: Article,,卷期:2012年287-8]
- Chemoresistance prevents effective cancer therapy and is rarely predictable prior to treatment, particularly for hepatocellular carcinoma (HCC). Following the chemoresistance profiling of eight HCC cell lines to each of ...
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