- Cancer Dormancy: A Model of Early Dissemination and Late Cancer Recurrence
[作者:Paez, D; Labonte, MJ; Bohanes, P; Zhang, W; Benhanim, L; Ning, Y; Wakatsuki, T; Loupakis, F; Lenz, HJ,期刊:Clinical Cancer Research, 页码:645-653 , 文章类型: Review,,卷期:2012年18-3]
- Cancer dormancy is a stage in tumor progression in which residual disease remains occult and asymptomatic for a prolonged period of time. Dormant tumor cells can be present as one of the earliest stages in tumor developm...
- Notch Signaling Promotes Growth and Invasion in Uveal Melanoma
[作者:Asnaghi, L; Ebrahimi, KB; Schreck, KC; Bar, EE; Coonfield, ML; Bell, WR; Handa, J; Merbs, SL; Harbour, JW; Eberhart, CG,期刊:Clinical Cancer Research, 页码:654-665 , 文章类型: Article,,卷期:2012年18-3]
- Purpose: To determine whether uveal melanoma, the most common primary intraocular malignancy in adults, requires Notch activity for growth and metastasis. Experimental Design: Expression of Notch pathway members was char...
- Modeling a Lethal Prostate Cancer Variant with Small-Cell Carcinoma Features
[作者:Tzelepi, V; Zhang, JX; Lu, JF; Kleb, B; Wu, GL; Wan, XH; Hoang, A; Efstathiou, E; Sircar, K; Navone, NM; Troncoso, P; Liang, SD; Logothetis, CJ; Maity, SN; Aparicio, AM,期刊:Clinical Cancer Research, 页码:666-677 , 文章类型: Article,,卷期:2012年18-3]
- Purpose: Small-cell prostate carcinoma (SCPC) morphology predicts for a distinct clinical behavior, resistance to androgen ablation, and frequent but short responses to chemotherapy. We sought to develop model systems th...
- Expansion of a CD8(+)PD-1(+) Replicative Senescence Phenotype in Early Stage CLL Patients Is Associated with Inverted CD4:CD8 Ratios and Disease Progression
[作者:Nunes, C; Wong, R; Mason, M; Fegan, C; Man, S; Pepper, C,期刊:Clinical Cancer Research, 页码:678-687 , 文章类型: Article,,卷期:2012年18-3]
- Purpose: Patients with chronic lymphocytic leukemia (CLL) display immune deficiency that is most obvious in advanced stage disease. Here we investigated whether this immune dysfunction plays a pathologic role in the prog...
- Primary Colorectal Cancers and Their Subsequent Hepatic Metastases Are Genetically Different: Implications for Selection of Patients for Targeted Treatment
[作者:Vermaat, JS; Nijman, IJ; Koudijs, MJ; Gerritse, FL; Scherer, SJ; Mokry, M; Roessingh, WM; Lansu, N; de Bruijn, E; van Hillegersberg, R; van Diest, PJ; Cuppen, E; Voest, EE,期刊:Clinical Cancer Research, 页码:688-699 , 文章类型: Article,,卷期:2012年18-3]
- Purpose: In the era of DNA-guided personalized cancer treatment, it is essential to conduct predictive analysis on the tissue that matters. Here, we analyzed genetic differences between primary colorectal adenocarcinomas...
- Genome-Wide CpG Island Profiling of Intraductal Papillary Mucinous Neoplasms of the Pancreas
[作者:Hong, SM; Omura, N; Vincent, A; Li, A; Knight, S; Yu, J; Hruban, RH; Goggins, M,期刊:Clinical Cancer Research, 页码:700-712 , 文章类型: Article,,卷期:2012年18-3]
- Purpose: Intraductal papillary mucinous neoplasms (IPMN) are precursors to infiltrating pancreatic ductal adenocarcinomas. Widespread epigenetic alterations are characteristic of many cancers, yet few studies have system...
- Upregulated IL-19 in Breast Cancer Promotes Tumor Progression and Affects Clinical Outcome
[作者:Hsing, CH; Cheng, HC; Hsu, YH; Chan, CH; Yeh, CH; Li, CF; Chang, MS,期刊:Clinical Cancer Research, 页码:713-725 , 文章类型: Article,,卷期:2012年18-3]
- Purpose: Interleukin (IL)-19 was expressed in invasive ductal carcinoma (IDC) of the breast tissue but not in healthy breast tissue. We explored the effects of IL-19 on the pathogenesis of breast cancer and its clinical ...
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