- Molecular Pathways: Beta-Adrenergic Signaling in Cancer
[作者:Cole, SW; Sood, AK,期刊:Clinical Cancer Research, 页码:1201-1206 , 文章类型: Article,,卷期:2012年18-5]
- Beta-adrenergic signaling has been found to regulate multiple cellular processes that contribute to the initiation and progression of cancer, including inflammation, angiogenesis, apoptosis/anoikis, cell motility and tra...
- Activation of PI3K Signaling in Merkel Cell Carcinoma
[作者:Nardi, V; Song, Y; Santamaria-Barria, JA; Cosper, AK; Lam, Q; Faber, AC; Boland, GM; Yeap, BY; Bergethon, K; Scialabba, VL; Tsao, H; Settleman, J; Ryan, DP; Borger, DR; Bhan, AK; Hoang, MP; Iafrate, AJ; Cusack, JC; Engelman, JA; Dias-Santagata, D,期刊:Clinical Cancer Research, 页码:1227-1236 , 文章类型: Article,,卷期:2012年18-5]
- Purpose: Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine tumor, often metastatic at presentation, for which current chemotherapeutic regimens are largely ineffective. As its pathogenesis is still un...
- Infiltration of Lynch Colorectal Cancers by Activated Immune Cells Associates with Early Staging of the Primary Tumor and Absence of Lymph Node Metastases
[作者:de Miranda, NFCC; Goudkade, D; Jordanova, ES; Tops, CMJ; Hes, FJ; Vasen, HFA; van Wezel, T; Morreau, H,期刊:Clinical Cancer Research, 页码:1237-1245 , 文章类型: Article,,卷期:2012年18-5]
- Purpose: Lynch syndrome colorectal cancers often lose human leukocyte antigen (HLA) class I expression. The outgrowth of clones with immune evasive phenotypes is thought to be positively selected by the action of cytotox...
- HDL of Patients with Type 2 Diabetes Mellitus Elevates the Capability of Promoting Breast Cancer Metastasis
[作者:Pan, B; Ren, H; He, YB; Lv, XF; Ma, YJ; Li, J; Huang, L; Yu, BQ; Kong, J; Niu, CG; Zhang, YY; Sun, WB; Zheng, LM,期刊:Clinical Cancer Research, 页码:1246-1256 , 文章类型: Article,,卷期:2012年18-5]
- Purpose: Epidemiologic studies suggested complicated associations between type 2 diabetes mellitus and breast cancer. High-density lipoprotein (HDL) is inversely associated with the risk and mortality of breast cancer. O...
- Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival
[作者:Gubanova, E; Brown, B; Ivanov, SV; Helleday, T; Mills, GB; Yarbrough, WG; Issaeva, N,期刊:Clinical Cancer Research, 页码:1257-1267 , 文章类型: Article,,卷期:2012年18-5]
- Purpose: Human papillomavirus (HPV) is linked with a subset of head and neck squamous cell carcinomas (HNSCC). HPV-positive HNSCCs show a better prognosis than HPV-negative HNSCCs, which may be explained by sensitivity o...
- Telomestatin Impairs Glioma Stem Cell Survival and Growth through the Disruption of Telomeric G-Quadruplex and Inhibition of the Proto-oncogene, c-Myb
[作者:Miyazaki, T; Pan, Y; Joshi, K; Purohit, D; Hu, B; Demir, H; Mazumder, S; Okabe, S; Yamori, T; Viapiano, M; Shin-ya, K; Seimiya, H; Nakano, I,期刊:Clinical Cancer Research, 页码:1268-1280 , 文章类型: Article,,卷期:2012年18-5]
- Purpose: Glioma stem cells (GSC) are a critical therapeutic target of glioblastoma multiforme (GBM). Experimental Design: The effects of a G-quadruplex ligand, telomestatin, were evaluated using patient-derived GSCs, non...
- SKI-606, an Src Inhibitor, Reduces Tumor Growth, Invasion, and Distant Metastasis in a Mouse Model of Thyroid Cancer
[作者:Kim, WG; Guigon, CJ; Fozzatti, L; Park, JW; Lu, CX; Willingham, MC; Cheng, SY,期刊:Clinical Cancer Research, 页码:1281-1290 , 文章类型: Article,,卷期:2012年18-5]
- Purpose: Src is overexpressed or hyperactivated in a variety of human cancers, including thyroid carcinoma. Src is a central mediator in multiple signaling pathways that are important in oncogenesis and cancer progressio...
- Polymeric Nanoparticle-Encapsulated Hedgehog Pathway Inhibitor HPI-1 (NanoHHI) Inhibits Systemic Metastases in an Orthotopic Model of Human Hepatocellular Carcinoma
[作者:Xu, Y; Chenna, V; Hu, CX; Sun, HX; Khan, M; Bai, HB; Yang, XR; Zhu, QF; Sun, YF; Maitra, A; Fan, J; Anders, RA,期刊:Clinical Cancer Research, 页码:1291-1302 , 文章类型: Article,,卷期:2012年18-5]
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- [F-18] FLT-PET Imaging Does Not Always "Light Up" Proliferating Tumor Cells
[作者:Zhang, CC; Yan, ZM; Li, WL; Kuszpit, K; Painter, CL; Zhang, Q; Lappin, PB; Nichols, T; Lira, ME; Affolter, T; Fahey, NR; Cullinane, C; Spilker, M; Zasadny, K; O'Brien, P; Buckman, D; Wong, A; Christensen, JG,期刊:Clinical Cancer Research, 页码:1303-1312 , 文章类型: Article,,卷期:2012年18-5]
- Purpose: [F-18] FLT (3'-Fluoro-3' deoxythymidine)-PET imaging was proposed as a tool for measuring in vivo tumor cell proliferation. The aim of this article was to validate the use of [F-18] FLT-PET imaging for measuring...
- Epidermal Growth Factor Receptor Protein Detection in Head and Neck Cancer Patients: A Many-Faceted Picture
[作者:Thariat, J; Etienne-Grimaldi, MC; Grall, D; Bensadoun, RJ; Cayre, A; Penault-Llorca, F; Veracini, L; Francoual, M; Formento, JL; Dassonville, O; De Raucourt, D; Geoffrois, L; Giraud, P; Racadot, S; Moriniere, S; Milano, G; Van Obberghen-Schilling, E,期刊:Clinical Cancer Research, 页码:1313-1322 , 文章类型: Article,,卷期:2012年18-5]
- Purpose: Epidermal growth factor receptor (EGFR) overexpression is associated with poor prognosis in head and neck squamous cell carcinoma (HNSCC). Despite intensive biomarker studies, a consensual method for assessing E...
- Combination of a Novel Gene Expression Signature with a Clinical Nomogram Improves the Prediction of Survival in High-Risk Bladder Cancer
[作者:Riester, M; Taylor, JM; Feifer, A; Koppie, T; Rosenberg, JE; Downey, RJ; Bochner, BH; Michor, F,期刊:Clinical Cancer Research, 页码:1323-1333 , 文章类型: Article,,卷期:2012年18-5]
- Purpose: We aimed to validate and improve prognostic signatures for high-risk urothelial carcinoma of the bladder. Experimental Design: We evaluated microarray data from 93 patients with bladder cancer managed by radical...
- Copy Number Losses Define Subgroups of Dedifferentiated Liposarcoma with Poor Prognosis and Genomic Instability
[作者:Crago, AM; Socci, ND; DeCarolis, P; O'Connor, R; Taylor, BS; Qin, LX; Antonescu, CR; Singer, S,期刊:Clinical Cancer Research, 页码:1334-1340 , 文章类型: Article,,卷期:2012年18-5]
- Purpose: Molecular events underlying progression of well-differentiated liposarcoma (WDLS) to dedifferentiated liposarcoma (DDLS) are poorly defined. This study sought to identify copy number alterations (CNA) associated...
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