- Optimization of vaccine responses with an E1, E2b and E3-deleted Ad5 vector circumvents pre-existing anti-vector immunity
[作者:Osada, T; Yang, XY; Hartman, ZC; Glass, O; Hodges, BL; Niedzwiecki, D; Morse, MA; Lyerly, HK; Amalfitano, A; Clay, TM,期刊:Cancer gene therapy, 页码:673-682 , 文章类型: Article,,卷期:2009年16-9]
- Recombinant serotype 5 adenovirus (Ad5) vectors lacking E1 expression induce robust immune responses against encoded transgenes in pre-clinical models, but have muted responses in human trials because of widespread pre-e...
- MLH1 deficiency enhances tumor cell sensitivity to ganciclovir
[作者:O'Konek, JJ; Boucher, PD; Iacco, AA; Wilson, TE; Shewach, DS,期刊:Cancer gene therapy, 页码:683-692 , 文章类型: Article,,卷期:2009年16-9]
- Suicide gene therapy with herpes simplex virus thymidine kinase (HSV-TK) and ganciclovir (GCV) is notable for producing multi-log cytotoxicity in a unique pattern of delayed cytotoxicity in S-phase. As hydroxyurea, a rib...
- Suppression of N-Ras by shRNA-expressing plasmid increases sensitivity of HepG2 cells to vincristine-induced growth inhibition
[作者:Sun, HX; He, HW; Zhang, SH; Liu, TG; Ren, KH; He, QY; Shao, RG,期刊:Cancer gene therapy, 页码:693-702 , 文章类型: Article,,卷期:2009年16-9]
- Oncogenic ras genes relate to the development of human cancers. In this study, we used a plasmid-mediated short-hairpin RNA (shRNA) targeting N-ras gene to combine with clinical drug vincristine (VCR) for the treatment o...
- Deletion of the E3-6.7K/gp19K region reduces the persistence of wild-type adenovirus in a permissive tumor model in Syrian hamsters
[作者:Bortolanza, S; Bunuales, M; Alzuguren, P; Lamas, O; Aldabe, R; Prieto, J; Hernandez-Alcoceba, R,期刊:Cancer gene therapy, 页码:703-712 , 文章类型: Article,,卷期:2009年16-9]
- A partial deletion of the adenovirus E3 region, comprising the overlapping 6.7K/gp19K genes, has been described for the incorporation of therapeutic genes in 'armed' oncolytic adenoviruses. This deletion allows the inser...
- DNAzymes to mouse beta 1 integrin mRNA in vivo: targeting the tumor vasculature and retarding cancer growth
[作者:Niewiarowska, J; Sacewicz, I; Wiktorska, M; Wysocki, T; Stasikowska, O; Wagrowska-Danilewicz, M; Cierniewski, CS,期刊:Cancer gene therapy, 页码:713-722 , 文章类型: Article,,卷期:2009年16-9]
- Previously, we designed a DNAzyme (beta 1DE) targeting the human beta 1 integrin subunit, which efficiently digested the mRNA of the beta 1 integrin subunit and downregulated beta 1 integrin expression in endothelial cel...
- Phase I and biodistribution study of recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene and ganciclovir administration in patients with head and neck cancer and other malignant tumors
[作者:Xu, F; Li, S; Li, XL; Guo, Y; Zou, BY; Xu, R; Liao, H; Zhao, HY; Zhang, Y; Guan, ZZ; Zhang, L,期刊:Cancer gene therapy, 页码:723-730 , 文章类型: Article,,卷期:2009年16-9]
- In this study, we investigated the safety and efficacy in cancer patients of a single intra-tumor injection of recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene (AdV/TK) followed by system...
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