- Phase II trial of Belagenpumatucel-L, a TGF-beta 2 antisense gene modified allogeneic tumor vaccine in advanced non small cell lung cancer (NSCLC) patients
[作者:Nemunaitis, J; Nemunaitis, M; Senzer, N; Snitz, P; Bedell, C; Kumar, P; Pappen, B; Maples, PB; Shawler, D; Fakhrai, H,期刊:Cancer gene therapy, 页码:620-624 , 文章类型: Article,,卷期:2009年16-8]
- In a previous dose escalation trial we demonstrated dose related survival correlation to Belagenpumatucel-L. In order to further evaluate safety and response at the previously defined optimal dose and schedule and to gai...
- INGN 007, an oncolytic adenovirus vector, replicates in Syrian hamsters but not mice: comparison of biodistribution studies
[作者:Ying, B; Toth, K; Spencer, JF; Meyer, J; Tollefson, AE; Patra, D; Dhar, D; Shashkova, EV; Kuppuswamy, M; Doronin, K; Thomas, MA; Zumstein, LA; Wold, WSM; Lichtenstein, DL,期刊:Cancer gene therapy, 页码:625-637 , 文章类型: Article,,卷期:2009年16-8]
- Preclinical biodistribution studies with INGN 007, an oncolytic adenovirus (Ad) vector, supporting an early stage clinical trial were conducted in Syrian hamsters, which are permissive for Ad replication, and mice, which...
- Effect of sonoporation on cationic liposome-mediated IFN beta gene therapy for metastatic hepatic tumors of murine colon cancer
[作者:Hayashi, S; Mizuno, M; Yoshida, J; Nakao, A,期刊:Cancer gene therapy, 页码:638-643 , 文章类型: Article,,卷期:2009年16-8]
- To examine the efficacy of ultrasound-mediated gene therapy in the treatment of hepatic cancer, we performed cationic liposome-mediated interferon-beta (IFN beta) gene therapy combined with sonoporation, using metastatic...
- An acute toxicology study with INGN 007, an oncolytic adenovirus vector, in mice and permissive Syrian hamsters; comparisons with wild-type Ad5 and a replication-defective adenovirus vector
[作者:Lichtenstein, DL; Spencer, JF; Doronin, K; Patra, D; Meyer, JM; Shashkova, EV; Kuppuswamy, M; Dhar, D; Thomas, MA; Tollefson, AE; Zumstein, LA; Wold, WSM; Toth, K,期刊:Cancer gene therapy, 页码:644-654 , 文章类型: Article,,卷期:2009年16-8]
- Oncolytic (replication-competent) adenoviruses as anticancer agents provide new, promising tools to fight cancer. In support of a Phase I clinical trial, here we report safety data with INGN 007 (VRX-007), an oncolytic a...
- Bifidobacterium longum as a delivery system of TRAIL and endostatin cooperates with chemotherapeutic drugs to inhibit hypoxic tumor growth
[作者:Hu, B; Kou, L; Li, C; Zhu, LP; Fan, YR; Wu, ZW; Wang, JJ; Xu, GX,期刊:Cancer gene therapy, 页码:655-663 , 文章类型: Article,,卷期:2009年16-8]
- In our previous study, we have shown that vector pBV22210 containing a chloramphenicol resistance and a cryptic plasmid pMB1 from Bifidobacterium longum strain could stably replicate and did not significantly affect the ...
- Controlling brain tumor growth by intraventricular administration of an AAV vector encoding IFN-beta
[作者:Meijer, DH; Maguire, CA; LeRoy, SG; Sena-Esteves, M,期刊:Cancer gene therapy, 页码:664-671 , 文章类型: Article,,卷期:2009年16-8]
- Glioblastoma multiforme (GBM) is the most aggressive type of all primary brain tumors, with an overall median survival < 1 year after diagnosis. Despite introduction of multimodal treatment approaches, the prognosis has ...
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